Click chemistry and drug delivery: A bird's-eye view
Click chemistry has been proven to be very useful in drug delivery. Due to the availability of a large number of click reactions with a various characteristics, selection of appropriate chemistry for a given application is often not a trivial task. This review is written for pharmaceutical researche...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-05-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383522004403 |
| _version_ | 1797823747967680512 |
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| author | Shameer M. Kondengadan Shubham Bansal Ce Yang Dongning Liu Zach Fultz Binghe Wang |
| author_facet | Shameer M. Kondengadan Shubham Bansal Ce Yang Dongning Liu Zach Fultz Binghe Wang |
| author_sort | Shameer M. Kondengadan |
| collection | DOAJ |
| description | Click chemistry has been proven to be very useful in drug delivery. Due to the availability of a large number of click reactions with a various characteristics, selection of appropriate chemistry for a given application is often not a trivial task. This review is written for pharmaceutical researchers who are interested in click chemistry applications and yet may not be click chemistry experts. For this, the review gives an overview of available click reactions organized by application types. Further, the general understanding of click reactions being fast and high yielding sometimes overshadows the need to analyze reaction kinetics in assessing suitability of a given reaction for certain applications. For this, we highlight the need to analyze the relationship among reaction kinetics, concentration effects, and reaction time scales, knowing that lack of such analysis could easily lead to failures. Further, possible issues such as chemical stability with various click reagents are also discussed to aid experimental designs. Recent examples and extensive references are also provided to aid in-depth understanding of technical details. We hope this review will help those interested in using click chemistry in drug delivery to select the appropriate reactions/reagents and minimize the number of pitfalls. |
| first_indexed | 2024-03-13T10:27:34Z |
| format | Article |
| id | doaj.art-159e168f4a6245538a5e6628789ce0c4 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-03-13T10:27:34Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-159e168f4a6245538a5e6628789ce0c42023-05-19T04:45:24ZengElsevierActa Pharmaceutica Sinica B2211-38352023-05-0113519902016Click chemistry and drug delivery: A bird's-eye viewShameer M. Kondengadan0Shubham Bansal1Ce Yang2Dongning Liu3Zach Fultz4Binghe Wang5Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USADepartment of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USADepartment of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USADepartment of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USADepartment of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USACorresponding author.; Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USAClick chemistry has been proven to be very useful in drug delivery. Due to the availability of a large number of click reactions with a various characteristics, selection of appropriate chemistry for a given application is often not a trivial task. This review is written for pharmaceutical researchers who are interested in click chemistry applications and yet may not be click chemistry experts. For this, the review gives an overview of available click reactions organized by application types. Further, the general understanding of click reactions being fast and high yielding sometimes overshadows the need to analyze reaction kinetics in assessing suitability of a given reaction for certain applications. For this, we highlight the need to analyze the relationship among reaction kinetics, concentration effects, and reaction time scales, knowing that lack of such analysis could easily lead to failures. Further, possible issues such as chemical stability with various click reagents are also discussed to aid experimental designs. Recent examples and extensive references are also provided to aid in-depth understanding of technical details. We hope this review will help those interested in using click chemistry in drug delivery to select the appropriate reactions/reagents and minimize the number of pitfalls.http://www.sciencedirect.com/science/article/pii/S2211383522004403Bioorthogonal chemistryBond-breaking reactionPROTACAntibody–drug conjugatesGasotransmitters |
| spellingShingle | Shameer M. Kondengadan Shubham Bansal Ce Yang Dongning Liu Zach Fultz Binghe Wang Click chemistry and drug delivery: A bird's-eye view Acta Pharmaceutica Sinica B Bioorthogonal chemistry Bond-breaking reaction PROTAC Antibody–drug conjugates Gasotransmitters |
| title | Click chemistry and drug delivery: A bird's-eye view |
| title_full | Click chemistry and drug delivery: A bird's-eye view |
| title_fullStr | Click chemistry and drug delivery: A bird's-eye view |
| title_full_unstemmed | Click chemistry and drug delivery: A bird's-eye view |
| title_short | Click chemistry and drug delivery: A bird's-eye view |
| title_sort | click chemistry and drug delivery a bird s eye view |
| topic | Bioorthogonal chemistry Bond-breaking reaction PROTAC Antibody–drug conjugates Gasotransmitters |
| url | http://www.sciencedirect.com/science/article/pii/S2211383522004403 |
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