The Curious Case of Nonrepetitive Centromeric DNA Sequences in <named-content content-type="genus-species">Candida auris</named-content> and Related Species
ABSTRACT 2009 saw the first description of Candida auris, a yeast pathogen of humans. C. auris has since grown into a global problem in intensive care settings, where it causes systemic infections in patients with underlying health issues. Recent whole-genome sequencing has discerned five C. auris c...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2021-08-01
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| Series: | mBio |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/mBio.01476-21 |
| _version_ | 1818567774928109568 |
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| author | Alexander Lorenz Nicolas Papon |
| author_facet | Alexander Lorenz Nicolas Papon |
| author_sort | Alexander Lorenz |
| collection | DOAJ |
| description | ABSTRACT 2009 saw the first description of Candida auris, a yeast pathogen of humans. C. auris has since grown into a global problem in intensive care settings, where it causes systemic infections in patients with underlying health issues. Recent whole-genome sequencing has discerned five C. auris clades with distinct phenotypic features which display genomic divergence on a DNA sequence and a chromosome structure level. In the absence of sexual reproduction in C. auris, the mechanism(s) behind the rapid genomic evolution of this emerging killer yeast has remained obscure. Yet, one important bit of information about chromosome organization was missing, the identification of the centromeres. In a recent study, Sanyal and coworkers (A. Narayanan, R. N. Vadnala, P. Ganguly, P. Selvakumar, et al., mBio 12:e00905-21, 2021, https://doi.org/10.1128/mBio.00905-21) filled this knowledge gap by mapping the centromeres in C. auris and its close relatives. This represents a major advance in the chromosome biology of the Candida/Clavispora clade. |
| first_indexed | 2024-12-14T06:27:43Z |
| format | Article |
| id | doaj.art-159e72fd2c534588a0ee5e02d1e38eb8 |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-12-14T06:27:43Z |
| publishDate | 2021-08-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-159e72fd2c534588a0ee5e02d1e38eb82022-12-21T23:13:38ZengAmerican Society for MicrobiologymBio2150-75112021-08-0112410.1128/mBio.01476-21The Curious Case of Nonrepetitive Centromeric DNA Sequences in <named-content content-type="genus-species">Candida auris</named-content> and Related SpeciesAlexander Lorenz0Nicolas Papon1Institute of Medical Sciences (IMS), University of Aberdeen, Aberdeen, United KingdomUniv Angers, Univ Brest, GEIHP, SFR ICAT, Angers, FranceABSTRACT 2009 saw the first description of Candida auris, a yeast pathogen of humans. C. auris has since grown into a global problem in intensive care settings, where it causes systemic infections in patients with underlying health issues. Recent whole-genome sequencing has discerned five C. auris clades with distinct phenotypic features which display genomic divergence on a DNA sequence and a chromosome structure level. In the absence of sexual reproduction in C. auris, the mechanism(s) behind the rapid genomic evolution of this emerging killer yeast has remained obscure. Yet, one important bit of information about chromosome organization was missing, the identification of the centromeres. In a recent study, Sanyal and coworkers (A. Narayanan, R. N. Vadnala, P. Ganguly, P. Selvakumar, et al., mBio 12:e00905-21, 2021, https://doi.org/10.1128/mBio.00905-21) filled this knowledge gap by mapping the centromeres in C. auris and its close relatives. This represents a major advance in the chromosome biology of the Candida/Clavispora clade.https://journals.asm.org/doi/10.1128/mBio.01476-21Candida auriscentromereschromosomeskaryotype evolutioncentromere |
| spellingShingle | Alexander Lorenz Nicolas Papon The Curious Case of Nonrepetitive Centromeric DNA Sequences in <named-content content-type="genus-species">Candida auris</named-content> and Related Species mBio Candida auris centromeres chromosomes karyotype evolution centromere |
| title | The Curious Case of Nonrepetitive Centromeric DNA Sequences in <named-content content-type="genus-species">Candida auris</named-content> and Related Species |
| title_full | The Curious Case of Nonrepetitive Centromeric DNA Sequences in <named-content content-type="genus-species">Candida auris</named-content> and Related Species |
| title_fullStr | The Curious Case of Nonrepetitive Centromeric DNA Sequences in <named-content content-type="genus-species">Candida auris</named-content> and Related Species |
| title_full_unstemmed | The Curious Case of Nonrepetitive Centromeric DNA Sequences in <named-content content-type="genus-species">Candida auris</named-content> and Related Species |
| title_short | The Curious Case of Nonrepetitive Centromeric DNA Sequences in <named-content content-type="genus-species">Candida auris</named-content> and Related Species |
| title_sort | curious case of nonrepetitive centromeric dna sequences in named content content type genus species candida auris named content and related species |
| topic | Candida auris centromeres chromosomes karyotype evolution centromere |
| url | https://journals.asm.org/doi/10.1128/mBio.01476-21 |
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