Stability Study of 0.5 g/mL Urea Oral Solution in InOrpha®
Urea is recommended in the 2nd line treatment in moderate to severe hyponatraemia induced by syndrome of inappropriate antidiuretic hormone secretion (SIADH), when water restriction is insufficient. A posology of 0.25–0.5 g/kg daily is suggested. A usual but inadequate urea oral preparation, i. e. 1...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2019-08-01
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| Series: | Pharmaceutical Technology in Hospital Pharmacy |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pthp-2019-0015 |
| _version_ | 1818735319332159488 |
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| author | Bourbon Johan Dory Anne Perello Laurent Belotti Laure Reisz Fanny Ubeaud-Sequier Genevieve Gourieux Bénédicte |
| author_facet | Bourbon Johan Dory Anne Perello Laurent Belotti Laure Reisz Fanny Ubeaud-Sequier Genevieve Gourieux Bénédicte |
| author_sort | Bourbon Johan |
| collection | DOAJ |
| description | Urea is recommended in the 2nd line treatment in moderate to severe hyponatraemia induced by syndrome of inappropriate antidiuretic hormone secretion (SIADH), when water restriction is insufficient. A posology of 0.25–0.5 g/kg daily is suggested. A usual but inadequate urea oral preparation, i. e. 10 g urea powder dissolved in 100 mL water before use, was classically compounded. Therefore the pharmacy has developed a 0.5 g/mL urea oral liquid solution in InOrpha® with better organoleptic characteristics to improve treatment adherence and reduce the preparation time. The aim of this study was to determine physicochemical and microbiological stability of the urea oral liquid solution in order to establish a shelf life of the preparation. |
| first_indexed | 2024-12-18T00:19:22Z |
| format | Article |
| id | doaj.art-159e74e9b9fe42b8b9fd463eef813ce4 |
| institution | Directory Open Access Journal |
| issn | 2365-2411 2365-242X |
| language | English |
| last_indexed | 2024-12-18T00:19:22Z |
| publishDate | 2019-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Pharmaceutical Technology in Hospital Pharmacy |
| spelling | doaj.art-159e74e9b9fe42b8b9fd463eef813ce42022-12-21T21:27:24ZengDe GruyterPharmaceutical Technology in Hospital Pharmacy2365-24112365-242X2019-08-0142697610.1515/pthp-2019-0015Stability Study of 0.5 g/mL Urea Oral Solution in InOrpha®Bourbon Johan0Dory Anne1Perello Laurent2Belotti Laure3Reisz Fanny4Ubeaud-Sequier Genevieve5Gourieux Bénédicte6Pharmacy Department, Hopitaux civils de Colmar, Colmar, FrancePharmacy-Sterilization, Hopitaux Universitaires de Strasbourg, NHC, rue Koeberle, Strasbourg67000, FrancePharmacy-sterilization, Hôpitaux Universitaires de Strasbourg, Strasbourg, FranceHygiene Laboratory, Hopitaux Universitaires de Strasbourg, Strasbourg, FrancePharmacy-sterilization, Hôpitaux Universitaires de Strasbourg, Strasbourg, FrancePharmacy-sterilization, Hôpitaux Universitaires de Strasbourg, Strasbourg, FrancePharmacy-sterilization, Hôpitaux Universitaires de Strasbourg, Strasbourg, FranceUrea is recommended in the 2nd line treatment in moderate to severe hyponatraemia induced by syndrome of inappropriate antidiuretic hormone secretion (SIADH), when water restriction is insufficient. A posology of 0.25–0.5 g/kg daily is suggested. A usual but inadequate urea oral preparation, i. e. 10 g urea powder dissolved in 100 mL water before use, was classically compounded. Therefore the pharmacy has developed a 0.5 g/mL urea oral liquid solution in InOrpha® with better organoleptic characteristics to improve treatment adherence and reduce the preparation time. The aim of this study was to determine physicochemical and microbiological stability of the urea oral liquid solution in order to establish a shelf life of the preparation.https://doi.org/10.1515/pthp-2019-0015ureahyponatremiaoral liquid solutionstabilityhplcuv-detection |
| spellingShingle | Bourbon Johan Dory Anne Perello Laurent Belotti Laure Reisz Fanny Ubeaud-Sequier Genevieve Gourieux Bénédicte Stability Study of 0.5 g/mL Urea Oral Solution in InOrpha® Pharmaceutical Technology in Hospital Pharmacy urea hyponatremia oral liquid solution stability hplc uv-detection |
| title | Stability Study of 0.5 g/mL Urea Oral Solution in InOrpha® |
| title_full | Stability Study of 0.5 g/mL Urea Oral Solution in InOrpha® |
| title_fullStr | Stability Study of 0.5 g/mL Urea Oral Solution in InOrpha® |
| title_full_unstemmed | Stability Study of 0.5 g/mL Urea Oral Solution in InOrpha® |
| title_short | Stability Study of 0.5 g/mL Urea Oral Solution in InOrpha® |
| title_sort | stability study of 0 5 g ml urea oral solution in inorpha r |
| topic | urea hyponatremia oral liquid solution stability hplc uv-detection |
| url | https://doi.org/10.1515/pthp-2019-0015 |
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