CRX-527 induced differentiation of HSCs protecting the intestinal epithelium from radiation damage

CRX-527 induced differentiation of HSCs protecting the intestinal epithelium from radiation damage

Recently, Toll-like receptors (TLRs) have been extensively studied in radiation damage, but the inherent defects of high toxicity and low efficacy of most TLR ligands limit their further clinical transformation. CRX-527, as a TLR4 ligand, has rarely been reported to protect against radiation. We dem...

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Bibliographic Details
Main Authors: Dongshu Liu, Suhe Dong, Cong Liu, Jicong Du, Sinian Wang, Huijie Yu, Wei Li, Zhongmin Chen, Renjun Peng, Qisheng Jiang, Mengying Zou, Fengsheng Li, Rong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
irradiation damage
hematopoiesis
intestinal stem cells
macrophage activation
TLR4 activation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.927213/full

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