Long-Term Results in Girls with Central Precocious Puberty After Leuprolide Acetate Treatment
Aim: Central precocious puberty (CPP) is the development of secondary sex characteristics before the age of 8 years in girls and 9 years in boys due to premature activation of the hypothalamic–pituitary–gonadal (HPG) axis. The aim of this study was to investigate the long-term pubertal data and heig...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2020-12-01
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| Series: | Namık Kemal Tıp Dergisi |
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| Online Access: |
http://namikkemalmedj.com/archives/archive-detail/article-preview/long-term-results-in-girls-with-central-precocious/43253
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| _version_ | 1797916891027603456 |
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| author | Esra BEŞER ÖZMEN Sibel TULGAR KINIK |
| author_facet | Esra BEŞER ÖZMEN Sibel TULGAR KINIK |
| author_sort | Esra BEŞER ÖZMEN |
| collection | DOAJ |
| description | Aim: Central precocious puberty (CPP) is the development of secondary sex characteristics before the age of 8 years in girls and 9 years in boys due to premature activation of the hypothalamic–pituitary–gonadal (HPG) axis. The aim of this study was to investigate the long-term pubertal data and height of girls treated with leuprolide acetate for CPP.Materials and Methods: A total of 70 girls followed up and treated for CPP between December 2002 and June 2013 were included in the study. Medical history, physical examination findings, maternal/paternal height, midparental height (MPH), laboratory and radiological findings, and weight, height, and body mass index (BMI) before and at end of treatment were recorded from the patients’ records. Age at menarche, menstrual regularity, and final height/BMI were determined in post-treatment follow-up.Results: The mean duration of leuprolide acetate therapy was 21.73±8.45 months, MPH was 158.3±4.5 cm, predicted adult height was 157.7±7.4 cm, and final height was 161.3±6.7 cm. Final height was moderately correlated with height-for-age at presentation (r=0.443, p<0.001), MPH (r=0.502, p<0.001), and height at admission and at end of treatment (r=0.462, p<0.001; r=0.610, p<0.001, respectively). Two patients (2.9%) had irregular menstrual periods. There was no significant difference between pre and post-treatment BMI values.Conclusion: Leuprolide acetate therapy was shown to be effective in suppressing the HPG axis, preventing the development of secondary sex characteristics, delaying menarche, and preserving final height. There were no adverse effects of the treatment in terms of obesity or menstrual irregularity. |
| first_indexed | 2024-04-10T13:04:30Z |
| format | Article |
| id | doaj.art-159f9031bf704f3584e1993e59fd73ce |
| institution | Directory Open Access Journal |
| issn | 2587-0262 |
| language | English |
| last_indexed | 2024-04-10T13:04:30Z |
| publishDate | 2020-12-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Namık Kemal Tıp Dergisi |
| spelling | doaj.art-159f9031bf704f3584e1993e59fd73ce2023-02-15T16:12:59ZengGalenos YayincilikNamık Kemal Tıp Dergisi2587-02622020-12-018336937510.37696/nkmj.71408513049054Long-Term Results in Girls with Central Precocious Puberty After Leuprolide Acetate TreatmentEsra BEŞER ÖZMEN0Sibel TULGAR KINIK1 Başkent Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Ankara, TÜRKİYE Başkent Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Endokrinoloji Bilim Dalı, Ankara, TÜRKİYE Aim: Central precocious puberty (CPP) is the development of secondary sex characteristics before the age of 8 years in girls and 9 years in boys due to premature activation of the hypothalamic–pituitary–gonadal (HPG) axis. The aim of this study was to investigate the long-term pubertal data and height of girls treated with leuprolide acetate for CPP.Materials and Methods: A total of 70 girls followed up and treated for CPP between December 2002 and June 2013 were included in the study. Medical history, physical examination findings, maternal/paternal height, midparental height (MPH), laboratory and radiological findings, and weight, height, and body mass index (BMI) before and at end of treatment were recorded from the patients’ records. Age at menarche, menstrual regularity, and final height/BMI were determined in post-treatment follow-up.Results: The mean duration of leuprolide acetate therapy was 21.73±8.45 months, MPH was 158.3±4.5 cm, predicted adult height was 157.7±7.4 cm, and final height was 161.3±6.7 cm. Final height was moderately correlated with height-for-age at presentation (r=0.443, p<0.001), MPH (r=0.502, p<0.001), and height at admission and at end of treatment (r=0.462, p<0.001; r=0.610, p<0.001, respectively). Two patients (2.9%) had irregular menstrual periods. There was no significant difference between pre and post-treatment BMI values.Conclusion: Leuprolide acetate therapy was shown to be effective in suppressing the HPG axis, preventing the development of secondary sex characteristics, delaying menarche, and preserving final height. There were no adverse effects of the treatment in terms of obesity or menstrual irregularity. http://namikkemalmedj.com/archives/archive-detail/article-preview/long-term-results-in-girls-with-central-precocious/43253 menstrual regulationfinal heightleuprolide acetateobesityprecocious puberty |
| spellingShingle | Esra BEŞER ÖZMEN Sibel TULGAR KINIK Long-Term Results in Girls with Central Precocious Puberty After Leuprolide Acetate Treatment Namık Kemal Tıp Dergisi menstrual regulation final height leuprolide acetate obesity precocious puberty |
| title | Long-Term Results in Girls with Central Precocious Puberty After Leuprolide Acetate Treatment |
| title_full | Long-Term Results in Girls with Central Precocious Puberty After Leuprolide Acetate Treatment |
| title_fullStr | Long-Term Results in Girls with Central Precocious Puberty After Leuprolide Acetate Treatment |
| title_full_unstemmed | Long-Term Results in Girls with Central Precocious Puberty After Leuprolide Acetate Treatment |
| title_short | Long-Term Results in Girls with Central Precocious Puberty After Leuprolide Acetate Treatment |
| title_sort | long term results in girls with central precocious puberty after leuprolide acetate treatment |
| topic | menstrual regulation final height leuprolide acetate obesity precocious puberty |
| url |
http://namikkemalmedj.com/archives/archive-detail/article-preview/long-term-results-in-girls-with-central-precocious/43253
|
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