The Contrasting Seasonality Patterns of Some Cancer-Types and Herpes Zoster Can Be Explained by a Binary Classification of Immunological Reactions
Zeev Elkoshi Research and Development Department, Taro Pharmaceutical Industries Ltd, Haifa, IsraelCorrespondence: Zeev Elkoshi, Email zeev.elkoshi@gmail.comAbstract: A binary classification of the pathogenic immune reactions as anti-inflammatory high-Treg reactions or pro-inflammatory low-Treg reac...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-12-01
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| Series: | Journal of Inflammation Research |
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| Online Access: | https://www.dovepress.com/the-contrasting-seasonality-patterns-of-some-cancer-types-and-herpes-z-peer-reviewed-fulltext-article-JIR |
| _version_ | 1811293317736955904 |
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| author | Elkoshi Z |
| author_facet | Elkoshi Z |
| author_sort | Elkoshi Z |
| collection | DOAJ |
| description | Zeev Elkoshi Research and Development Department, Taro Pharmaceutical Industries Ltd, Haifa, IsraelCorrespondence: Zeev Elkoshi, Email zeev.elkoshi@gmail.comAbstract: A binary classification of the pathogenic immune reactions as anti-inflammatory high-Treg reactions or pro-inflammatory low-Treg reactions explains both the relatively low incidence rate of several types of cancer, and the relatively high incidence rate of herpes zoster cases diagnosed in the summer compared to cases diagnosed in the winter (in regions with temperate climate). This binary model also elucidates the longer survival of cancer patients diagnosed during the summer compared to these diagnosed in the winter. The three key elements of this explanation are: (a) the effect of sunlight on Treg production; (b) the evolvement of cancer from a low-Treg condition at early stage, to a high-Treg condition at advanced stage, and (c) the evolvement of herpes zoster from a high-Treg condition at pre-exudative stage to a low-Treg condition at acute exudative stage. A significant proportion of indolent tumors at the time of diagnosis (> 20%) is a prerequisite for a beneficial effect of sunlight on cancer incidence rate and prognosis. This prerequisite restricts the beneficial effect of diagnosis during summer to certain types of cancer. Clinical implication: the prognosis of early stage tumors may be improved by a course of corticosteroid (or other immunosuppressant) treatment.Keywords: cancer, herpes zoster, Treg cells, vitamin D, UV radiation, incidence rate, cancer prognosis |
| first_indexed | 2024-04-13T04:59:35Z |
| format | Article |
| id | doaj.art-15a1a0792dc34464bd69e9808e3f8247 |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-04-13T04:59:35Z |
| publishDate | 2022-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-15a1a0792dc34464bd69e9808e3f82472022-12-22T03:01:22ZengDove Medical PressJournal of Inflammation Research1178-70312022-12-01Volume 156761677180354The Contrasting Seasonality Patterns of Some Cancer-Types and Herpes Zoster Can Be Explained by a Binary Classification of Immunological ReactionsElkoshi ZZeev Elkoshi Research and Development Department, Taro Pharmaceutical Industries Ltd, Haifa, IsraelCorrespondence: Zeev Elkoshi, Email zeev.elkoshi@gmail.comAbstract: A binary classification of the pathogenic immune reactions as anti-inflammatory high-Treg reactions or pro-inflammatory low-Treg reactions explains both the relatively low incidence rate of several types of cancer, and the relatively high incidence rate of herpes zoster cases diagnosed in the summer compared to cases diagnosed in the winter (in regions with temperate climate). This binary model also elucidates the longer survival of cancer patients diagnosed during the summer compared to these diagnosed in the winter. The three key elements of this explanation are: (a) the effect of sunlight on Treg production; (b) the evolvement of cancer from a low-Treg condition at early stage, to a high-Treg condition at advanced stage, and (c) the evolvement of herpes zoster from a high-Treg condition at pre-exudative stage to a low-Treg condition at acute exudative stage. A significant proportion of indolent tumors at the time of diagnosis (> 20%) is a prerequisite for a beneficial effect of sunlight on cancer incidence rate and prognosis. This prerequisite restricts the beneficial effect of diagnosis during summer to certain types of cancer. Clinical implication: the prognosis of early stage tumors may be improved by a course of corticosteroid (or other immunosuppressant) treatment.Keywords: cancer, herpes zoster, Treg cells, vitamin D, UV radiation, incidence rate, cancer prognosishttps://www.dovepress.com/the-contrasting-seasonality-patterns-of-some-cancer-types-and-herpes-z-peer-reviewed-fulltext-article-JIRcancerherpes zostertreg cellsvitamin duv radiationincidence ratecancer prognosis |
| spellingShingle | Elkoshi Z The Contrasting Seasonality Patterns of Some Cancer-Types and Herpes Zoster Can Be Explained by a Binary Classification of Immunological Reactions Journal of Inflammation Research cancer herpes zoster treg cells vitamin d uv radiation incidence rate cancer prognosis |
| title | The Contrasting Seasonality Patterns of Some Cancer-Types and Herpes Zoster Can Be Explained by a Binary Classification of Immunological Reactions |
| title_full | The Contrasting Seasonality Patterns of Some Cancer-Types and Herpes Zoster Can Be Explained by a Binary Classification of Immunological Reactions |
| title_fullStr | The Contrasting Seasonality Patterns of Some Cancer-Types and Herpes Zoster Can Be Explained by a Binary Classification of Immunological Reactions |
| title_full_unstemmed | The Contrasting Seasonality Patterns of Some Cancer-Types and Herpes Zoster Can Be Explained by a Binary Classification of Immunological Reactions |
| title_short | The Contrasting Seasonality Patterns of Some Cancer-Types and Herpes Zoster Can Be Explained by a Binary Classification of Immunological Reactions |
| title_sort | contrasting seasonality patterns of some cancer types and herpes zoster can be explained by a binary classification of immunological reactions |
| topic | cancer herpes zoster treg cells vitamin d uv radiation incidence rate cancer prognosis |
| url | https://www.dovepress.com/the-contrasting-seasonality-patterns-of-some-cancer-types-and-herpes-z-peer-reviewed-fulltext-article-JIR |
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