Targeting CB2R in astrocytes for Parkinson's disease therapy: unraveling the Foxg1-mediated neuroprotective mechanism through autophagy-mediated NLRP3 degradation

Targeting CB2R in astrocytes for Parkinson's disease therapy: unraveling the Foxg1-mediated neuroprotective mechanism through autophagy-mediated NLRP3 degradation

Abstract Background Inflammasomes in astrocytes have been shown to play a crucial role in the pathogenesis of neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD). Cannabinoid Receptor 2(CB2R), a G protein-coupled receptor (GPCR), is considered a promisi...

Full description

Bibliographic Details
Main Authors: Hong Zhu, Feng Xiao, Yao Xiao, Yun Guo, Xuesong Shan, Zhe Zhang, Lieliang Zhang, Hua Guo
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Neuroinflammation
Subjects:
CB2R
NLRP3
Autophagy
Parkinson disease
Online Access:https://doi.org/10.1186/s12974-023-02989-2

Similar Items

Similar Items