CEP-1347 Dually Targets MDM4 and PKC to Activate p53 and Inhibit the Growth of Uveal Melanoma Cells

CEP-1347 Dually Targets MDM4 and PKC to Activate p53 and Inhibit the Growth of Uveal Melanoma Cells

Uveal melanoma (UM) is among the most common primary intraocular neoplasms in adults, with limited therapeutic options for advanced/metastatic disease. Since UM is characterized by infrequent p53 mutation coupled with the overexpression of MDM4, a major negative regulator of p53, we aimed to investi...

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Bibliographic Details
Main Authors: Keita Togashi, Shuhei Suzuki, Yuta Mitobe, Yurika Nakagawa-Saito, Asuka Sugai, Senri Takenouchi, Masahiko Sugimoto, Chifumi Kitanaka, Masashi Okada
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cancers
Subjects:
intraocular malignancy
MDMX
KT7515
choroid
ciliary body
iris
Online Access:https://www.mdpi.com/2072-6694/16/1/118

Internet

https://www.mdpi.com/2072-6694/16/1/118

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