Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives
Artemisinin and its derivatives have been reported to be experimentally effective for the treatment of highly aggressive cancers without developing drug resistance, they are useful for the treatment of malaria, other protozoal infections and they exhibit antiviral activity. However, they are limited...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-02-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/22/2/323 |
| _version_ | 1818959183839494144 |
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| author | Blessing Atim Aderibigbe |
| author_facet | Blessing Atim Aderibigbe |
| author_sort | Blessing Atim Aderibigbe |
| collection | DOAJ |
| description | Artemisinin and its derivatives have been reported to be experimentally effective for the treatment of highly aggressive cancers without developing drug resistance, they are useful for the treatment of malaria, other protozoal infections and they exhibit antiviral activity. However, they are limited pharmacologically by their poor bioavailability, short half-life in vivo, poor water solubility and long term usage results in toxicity. They are also expensive for the treatment of malaria when compared to other antimalarials. In order to enhance their therapeutic efficacy, they are incorporated onto different drug delivery systems, thus yielding improved biological outcomes. This review article is focused on the currently synthesized derivatives of artemisinin and different delivery systems used for the incorporation of artemisinin and its derivatives. |
| first_indexed | 2024-12-20T11:37:36Z |
| format | Article |
| id | doaj.art-15a4c44de881454fbe9bab9bf5487f51 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-20T11:37:36Z |
| publishDate | 2017-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-15a4c44de881454fbe9bab9bf5487f512022-12-21T19:42:04ZengMDPI AGMolecules1420-30492017-02-0122232310.3390/molecules22020323molecules22020323Design of Drug Delivery Systems Containing Artemisinin and Its DerivativesBlessing Atim Aderibigbe0Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape 5700, South AfricaArtemisinin and its derivatives have been reported to be experimentally effective for the treatment of highly aggressive cancers without developing drug resistance, they are useful for the treatment of malaria, other protozoal infections and they exhibit antiviral activity. However, they are limited pharmacologically by their poor bioavailability, short half-life in vivo, poor water solubility and long term usage results in toxicity. They are also expensive for the treatment of malaria when compared to other antimalarials. In order to enhance their therapeutic efficacy, they are incorporated onto different drug delivery systems, thus yielding improved biological outcomes. This review article is focused on the currently synthesized derivatives of artemisinin and different delivery systems used for the incorporation of artemisinin and its derivatives.http://www.mdpi.com/1420-3049/22/2/323artemisininartesunateartemetherarteetherdrug delivery systems |
| spellingShingle | Blessing Atim Aderibigbe Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives Molecules artemisinin artesunate artemether arteether drug delivery systems |
| title | Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives |
| title_full | Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives |
| title_fullStr | Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives |
| title_full_unstemmed | Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives |
| title_short | Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives |
| title_sort | design of drug delivery systems containing artemisinin and its derivatives |
| topic | artemisinin artesunate artemether arteether drug delivery systems |
| url | http://www.mdpi.com/1420-3049/22/2/323 |
| work_keys_str_mv | AT blessingatimaderibigbe designofdrugdeliverysystemscontainingartemisininanditsderivatives |