Increased risk of psychosis to ivermectin treatment
Introduction Adolescence: a state of mental fragility, where psychiatric disorders may debut, where have been reported several cases of toxidermy, encephalopathy and neuropsychiatric disorder related to ivermectin treatment (excluding organicity, substance abuse or medication) (1). It has effect on...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822020673/type/journal_article |
| _version_ | 1797616978384388096 |
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| author | A. Romero Calderon M. Marín Valdovino A.M. González Meléndez J. Leiva Soto A. Garcia Baltazar |
| author_facet | A. Romero Calderon M. Marín Valdovino A.M. González Meléndez J. Leiva Soto A. Garcia Baltazar |
| author_sort | A. Romero Calderon |
| collection | DOAJ |
| description |
Introduction
Adolescence: a state of mental fragility, where psychiatric disorders may debut, where have been reported several cases of toxidermy, encephalopathy and neuropsychiatric disorder related to ivermectin treatment (excluding organicity, substance abuse or medication) (1). It has effect on the dopaminergic system with an alteration on glycoprotein P leading to high levels of ivermectin causing neurotoxicity (2). In this poster, we discuss the case of a 14 y/o´s psychosis to ivermectin
Objectives
Presentation of a clinical report
Methods
14 years old woman. Background: father with schizophrenia. Comorbility: None. Initially, presented to ER with 2 week of treatment to ivermectin 6mg for pediculosis; presenting first psychotic episode. She presented first clinical outbreak of psychosis characterized by mystical-religious, erotomaniac, harm and reference delusions, auditory and visual hallucinations adding isolation, abulia, apathy, dialogued soliloquies, and spontaneous crying. No prior psychiatric treatment.
Results
In hospitalization: elevated indirect and direct bilirubins and hiponatremia; neuroimaging studies are reported normal. Haloperidol 7.5 mg/day is indicated and parkinsonism is presented. Treatment is changed to olanzapine 15mg/day with notorious improvement. Diagnostic impression: Acute polymorphic psychotic disorder with symptoms of schizophrenia
Conclusions
Possible causes were analyzed, finding a relationship with ivermectin treatment. This case makes evident the importance of conducting in-depht evaluations and finding risks factors for psychosis.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:48:56Z |
| format | Article |
| id | doaj.art-15a66d2a0b694fd795eb3e6819525f14 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:48:56Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-15a66d2a0b694fd795eb3e6819525f142023-11-17T05:07:03ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S800S80010.1192/j.eurpsy.2022.2067Increased risk of psychosis to ivermectin treatmentA. Romero Calderon0M. Marín Valdovino1A.M. González Meléndez2J. Leiva Soto3A. Garcia Baltazar4HOSPITAL SAN JUAN DE DIOS, EnseÑanza, ZAPOPAN, MexicoHOSPITAL SAN JUAN DE DIOS, EnseÑanza, ZAPOPAN, MexicoHospital San Juan De Dios, Psiquiatria, Zapopan, MexicoHOSPITAL SAN JUAN DE DIOS, EnseÑanza, ZAPOPAN, MexicoHOSPITAL SAN JUAN DE DIOS, EnseÑanza, ZAPOPAN, Mexico Introduction Adolescence: a state of mental fragility, where psychiatric disorders may debut, where have been reported several cases of toxidermy, encephalopathy and neuropsychiatric disorder related to ivermectin treatment (excluding organicity, substance abuse or medication) (1). It has effect on the dopaminergic system with an alteration on glycoprotein P leading to high levels of ivermectin causing neurotoxicity (2). In this poster, we discuss the case of a 14 y/o´s psychosis to ivermectin Objectives Presentation of a clinical report Methods 14 years old woman. Background: father with schizophrenia. Comorbility: None. Initially, presented to ER with 2 week of treatment to ivermectin 6mg for pediculosis; presenting first psychotic episode. She presented first clinical outbreak of psychosis characterized by mystical-religious, erotomaniac, harm and reference delusions, auditory and visual hallucinations adding isolation, abulia, apathy, dialogued soliloquies, and spontaneous crying. No prior psychiatric treatment. Results In hospitalization: elevated indirect and direct bilirubins and hiponatremia; neuroimaging studies are reported normal. Haloperidol 7.5 mg/day is indicated and parkinsonism is presented. Treatment is changed to olanzapine 15mg/day with notorious improvement. Diagnostic impression: Acute polymorphic psychotic disorder with symptoms of schizophrenia Conclusions Possible causes were analyzed, finding a relationship with ivermectin treatment. This case makes evident the importance of conducting in-depht evaluations and finding risks factors for psychosis. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822020673/type/journal_articleIvermectinPsychosis |
| spellingShingle | A. Romero Calderon M. Marín Valdovino A.M. González Meléndez J. Leiva Soto A. Garcia Baltazar Increased risk of psychosis to ivermectin treatment European Psychiatry Ivermectin Psychosis |
| title | Increased risk of psychosis to ivermectin treatment |
| title_full | Increased risk of psychosis to ivermectin treatment |
| title_fullStr | Increased risk of psychosis to ivermectin treatment |
| title_full_unstemmed | Increased risk of psychosis to ivermectin treatment |
| title_short | Increased risk of psychosis to ivermectin treatment |
| title_sort | increased risk of psychosis to ivermectin treatment |
| topic | Ivermectin Psychosis |
| url | https://www.cambridge.org/core/product/identifier/S0924933822020673/type/journal_article |
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