The Relationship Between Sleep, Cognition and Behavior in Children With Newly-Diagnosed Epilepsy Over 36 Months
IntroductionThere is substantial evidence that children with epilepsy experience more sleep, behavior and cognitive challenges than children without epilepsy. However, the literature is limited in describing the relationship between sleep, epilepsy, cognition and behavioral challenges and the intera...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.903137/full |
| _version_ | 1811222462620237824 |
|---|---|
| author | Temitayo Oyegbile-Chidi Danielle Harvey Jordan Eisner David Dunn Jana Jones Anna Byars Bruce Hermann Joan Austin |
| author_facet | Temitayo Oyegbile-Chidi Danielle Harvey Jordan Eisner David Dunn Jana Jones Anna Byars Bruce Hermann Joan Austin |
| author_sort | Temitayo Oyegbile-Chidi |
| collection | DOAJ |
| description | IntroductionThere is substantial evidence that children with epilepsy experience more sleep, behavior and cognitive challenges than children without epilepsy. However, the literature is limited in describing the relationship between sleep, epilepsy, cognition and behavioral challenges and the interactions amongst these factors over time. This study aims to understand the nature and strength of the relationship between sleep, cognition, mood and behavior in children with new-onset epilepsy as assessed by multiple informants at multiple time periods using multiple different dependent measures.Methods332 participants (6–16years) were recruited within 6 weeks of their first recognized seizure. The comparison group was comprised of 266 healthy siblings. Participants underwent sleep evaluation by a parent using the Sleep Behavioral Questionnaire (SBQ), cognitive evaluation using a comprehensive neuropsychological test battery, a behavioral evaluation using the Child Behavior Checklist (CBCL from parents and TRF from teachers) and the Children's Depression Inventory (CDI). These evaluations were completed at baseline (B), at 18 months, and at 36 months.ResultsCompared to siblings, children with new-onset epilepsy had more sleep disturbance (SBQ), higher rates of behavioral problems (CBCL and TRF), lower cognitive testing scores, and higher rates of depression; which persisted over the 36-month study. Sleep significantly correlated with behavioral problems, cognitive scores and depression. When divided into categories based of sleep disturbance scores, 39.7% of children with epilepsy experienced “Persistently Abnormal Sleep”, while 14.8% experienced “Persistently Normal Sleep”. Children with persistently abnormal sleep experienced the highest rates of behavioral problems, depression and cognitive impairment compared to those with persistently normal sleep, regardless of epilepsy syndrome. Younger age of seizure onset, younger age at testing, and lower grade level at baseline were associated with persistently abnormal sleep.ConclusionsTo our knowledge, this is the first demonstration of the nature, strength, reliability, stability and persistence of the relationship between sleep, cognition, and behavioral problems over time in a large cohort of children with newly diagnosed epilepsy, as assessed by multiple informants at different timepoints. The results of this study indicate that children with epilepsy are at a high risk of significant persisting neurobehavioral multimorbidity. Therefore, early screening for these challenges may be essential for optimizing quality of life long-term. |
| first_indexed | 2024-04-12T08:16:17Z |
| format | Article |
| id | doaj.art-15a89f276b1347f18c01f5600a4231ff |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T08:16:17Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-15a89f276b1347f18c01f5600a4231ff2022-12-22T03:40:45ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-07-011310.3389/fneur.2022.903137903137The Relationship Between Sleep, Cognition and Behavior in Children With Newly-Diagnosed Epilepsy Over 36 MonthsTemitayo Oyegbile-Chidi0Danielle Harvey1Jordan Eisner2David Dunn3Jana Jones4Anna Byars5Bruce Hermann6Joan Austin7Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA, United StatesDepartment of Public Health Sciences, School of Medicine, University of California, Davis, Sacramento, CA, United StatesDepartment of Neurology, School of Medicine, University of California, Davis, Sacramento, CA, United StatesDepartment of Psychiatry, School of Medicine, Indiana University, Indianapolis, IN, United StatesDepartment of Neurology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United StatesDepartment of Pediatrics, Cincinnati Children's Hospital at the University of Cincinnati, University of Cincinnati, Cincinnati, OH, United StatesDepartment of Neurology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United StatesSchool of Nursing, Indiana University, Indianapolis, IN, United StatesIntroductionThere is substantial evidence that children with epilepsy experience more sleep, behavior and cognitive challenges than children without epilepsy. However, the literature is limited in describing the relationship between sleep, epilepsy, cognition and behavioral challenges and the interactions amongst these factors over time. This study aims to understand the nature and strength of the relationship between sleep, cognition, mood and behavior in children with new-onset epilepsy as assessed by multiple informants at multiple time periods using multiple different dependent measures.Methods332 participants (6–16years) were recruited within 6 weeks of their first recognized seizure. The comparison group was comprised of 266 healthy siblings. Participants underwent sleep evaluation by a parent using the Sleep Behavioral Questionnaire (SBQ), cognitive evaluation using a comprehensive neuropsychological test battery, a behavioral evaluation using the Child Behavior Checklist (CBCL from parents and TRF from teachers) and the Children's Depression Inventory (CDI). These evaluations were completed at baseline (B), at 18 months, and at 36 months.ResultsCompared to siblings, children with new-onset epilepsy had more sleep disturbance (SBQ), higher rates of behavioral problems (CBCL and TRF), lower cognitive testing scores, and higher rates of depression; which persisted over the 36-month study. Sleep significantly correlated with behavioral problems, cognitive scores and depression. When divided into categories based of sleep disturbance scores, 39.7% of children with epilepsy experienced “Persistently Abnormal Sleep”, while 14.8% experienced “Persistently Normal Sleep”. Children with persistently abnormal sleep experienced the highest rates of behavioral problems, depression and cognitive impairment compared to those with persistently normal sleep, regardless of epilepsy syndrome. Younger age of seizure onset, younger age at testing, and lower grade level at baseline were associated with persistently abnormal sleep.ConclusionsTo our knowledge, this is the first demonstration of the nature, strength, reliability, stability and persistence of the relationship between sleep, cognition, and behavioral problems over time in a large cohort of children with newly diagnosed epilepsy, as assessed by multiple informants at different timepoints. The results of this study indicate that children with epilepsy are at a high risk of significant persisting neurobehavioral multimorbidity. Therefore, early screening for these challenges may be essential for optimizing quality of life long-term.https://www.frontiersin.org/articles/10.3389/fneur.2022.903137/fullepilepsysleep disturbancespediatriccognitionbehaviormood |
| spellingShingle | Temitayo Oyegbile-Chidi Danielle Harvey Jordan Eisner David Dunn Jana Jones Anna Byars Bruce Hermann Joan Austin The Relationship Between Sleep, Cognition and Behavior in Children With Newly-Diagnosed Epilepsy Over 36 Months Frontiers in Neurology epilepsy sleep disturbances pediatric cognition behavior mood |
| title | The Relationship Between Sleep, Cognition and Behavior in Children With Newly-Diagnosed Epilepsy Over 36 Months |
| title_full | The Relationship Between Sleep, Cognition and Behavior in Children With Newly-Diagnosed Epilepsy Over 36 Months |
| title_fullStr | The Relationship Between Sleep, Cognition and Behavior in Children With Newly-Diagnosed Epilepsy Over 36 Months |
| title_full_unstemmed | The Relationship Between Sleep, Cognition and Behavior in Children With Newly-Diagnosed Epilepsy Over 36 Months |
| title_short | The Relationship Between Sleep, Cognition and Behavior in Children With Newly-Diagnosed Epilepsy Over 36 Months |
| title_sort | relationship between sleep cognition and behavior in children with newly diagnosed epilepsy over 36 months |
| topic | epilepsy sleep disturbances pediatric cognition behavior mood |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.903137/full |
| work_keys_str_mv | AT temitayooyegbilechidi therelationshipbetweensleepcognitionandbehaviorinchildrenwithnewlydiagnosedepilepsyover36months AT danielleharvey therelationshipbetweensleepcognitionandbehaviorinchildrenwithnewlydiagnosedepilepsyover36months AT jordaneisner therelationshipbetweensleepcognitionandbehaviorinchildrenwithnewlydiagnosedepilepsyover36months AT daviddunn therelationshipbetweensleepcognitionandbehaviorinchildrenwithnewlydiagnosedepilepsyover36months AT janajones therelationshipbetweensleepcognitionandbehaviorinchildrenwithnewlydiagnosedepilepsyover36months AT annabyars therelationshipbetweensleepcognitionandbehaviorinchildrenwithnewlydiagnosedepilepsyover36months AT brucehermann therelationshipbetweensleepcognitionandbehaviorinchildrenwithnewlydiagnosedepilepsyover36months AT joanaustin therelationshipbetweensleepcognitionandbehaviorinchildrenwithnewlydiagnosedepilepsyover36months AT temitayooyegbilechidi relationshipbetweensleepcognitionandbehaviorinchildrenwithnewlydiagnosedepilepsyover36months AT danielleharvey relationshipbetweensleepcognitionandbehaviorinchildrenwithnewlydiagnosedepilepsyover36months AT jordaneisner relationshipbetweensleepcognitionandbehaviorinchildrenwithnewlydiagnosedepilepsyover36months AT daviddunn relationshipbetweensleepcognitionandbehaviorinchildrenwithnewlydiagnosedepilepsyover36months AT janajones relationshipbetweensleepcognitionandbehaviorinchildrenwithnewlydiagnosedepilepsyover36months AT annabyars relationshipbetweensleepcognitionandbehaviorinchildrenwithnewlydiagnosedepilepsyover36months AT brucehermann relationshipbetweensleepcognitionandbehaviorinchildrenwithnewlydiagnosedepilepsyover36months AT joanaustin relationshipbetweensleepcognitionandbehaviorinchildrenwithnewlydiagnosedepilepsyover36months |