Antimicrobial Use-Related Problems Among Hospitalized Pediatric Patients: A Prospective Observational Study
Kidu Gidey, Solomon Girmay Aregawi, Berhane Yohannes Hailu, Solomon Weldegebreal Asgedom, Yirga Legesse Niriayo Department of Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, EthiopiaCorrespondence: Kidu Gidey, Email kidu.gidey@mu.edu.etIntroduction: An...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-01-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/antimicrobial-use-related-problems-among-hospitalized-pediatric-patien-peer-reviewed-fulltext-article-IDR |
| _version_ | 1797357128162213888 |
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| author | Gidey K Aregawi SG Hailu BY Asgedom SW Niriayo YL |
| author_facet | Gidey K Aregawi SG Hailu BY Asgedom SW Niriayo YL |
| author_sort | Gidey K |
| collection | DOAJ |
| description | Kidu Gidey, Solomon Girmay Aregawi, Berhane Yohannes Hailu, Solomon Weldegebreal Asgedom, Yirga Legesse Niriayo Department of Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, EthiopiaCorrespondence: Kidu Gidey, Email kidu.gidey@mu.edu.etIntroduction: Antimicrobials are among the most commonly misused medications, leading to antimicrobial resistance, and therefore demand more attention. There are limited studies documenting “antimicrobial use-related problems” in developing countries, especially in pediatric patients.Objectives: This study aimed to evaluate the prevalence of antimicrobial use-related problems and risk factors among hospitalized pediatric patients.Materials and Methods: A hospital-based prospective observational study was conducted in Ayder comprehensive specialized hospital (ACSH) in the Tigray region, Ethiopia. The participants of the study were pediatric patients aged ≤ 15 years who were admitted with a diagnosis of infectious disease between September 2019 and November 2019.Results: A total of 232 pediatric patients were included in the study. Of these, 59.5% of the patients were male and the mean age (SD) of the patients was 5.8 (5.2) years. Of the 232 patients surveyed, a total of 177 antimicrobial use-related problems were identified. One or more antimicrobial use-related problems have occurred in more than half of the patients (53.9%). The commonest antimicrobial use problems were unnecessary antimicrobial therapy (22.8%) followed by need additional antimicrobial therapy (16.4%). In a multivariate logistic regression model, patients with comorbidities (Adjusted odds ratio (AOR): 1.84, 95% confidence interval (CI): 1.04– 3.27) and hospital stays exceeding one week (AOR=1.88, 95% CI: 1.08– 3.26) were predictors of antimicrobial use-related problems.Conclusion: Antimicrobial use-related problems were found in a significant proportion of pediatric patients. Addressing these issues necessitates collaborative efforts, emphasizing targeted education, strengthened antimicrobial stewardship, ensuring responsible antimicrobial use and enhancing pediatric care.Keywords: antimicrobial use-related problems, pediatric, Ethiopia |
| first_indexed | 2024-03-08T14:40:27Z |
| format | Article |
| id | doaj.art-15a95f69b4cf40e9abf6e4095f49ba34 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-03-08T14:40:27Z |
| publishDate | 2024-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-15a95f69b4cf40e9abf6e4095f49ba342024-01-11T18:05:55ZengDove Medical PressInfection and Drug Resistance1178-69732024-01-01Volume 1711913089666Antimicrobial Use-Related Problems Among Hospitalized Pediatric Patients: A Prospective Observational StudyGidey KAregawi SGHailu BYAsgedom SWNiriayo YLKidu Gidey, Solomon Girmay Aregawi, Berhane Yohannes Hailu, Solomon Weldegebreal Asgedom, Yirga Legesse Niriayo Department of Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, EthiopiaCorrespondence: Kidu Gidey, Email kidu.gidey@mu.edu.etIntroduction: Antimicrobials are among the most commonly misused medications, leading to antimicrobial resistance, and therefore demand more attention. There are limited studies documenting “antimicrobial use-related problems” in developing countries, especially in pediatric patients.Objectives: This study aimed to evaluate the prevalence of antimicrobial use-related problems and risk factors among hospitalized pediatric patients.Materials and Methods: A hospital-based prospective observational study was conducted in Ayder comprehensive specialized hospital (ACSH) in the Tigray region, Ethiopia. The participants of the study were pediatric patients aged ≤ 15 years who were admitted with a diagnosis of infectious disease between September 2019 and November 2019.Results: A total of 232 pediatric patients were included in the study. Of these, 59.5% of the patients were male and the mean age (SD) of the patients was 5.8 (5.2) years. Of the 232 patients surveyed, a total of 177 antimicrobial use-related problems were identified. One or more antimicrobial use-related problems have occurred in more than half of the patients (53.9%). The commonest antimicrobial use problems were unnecessary antimicrobial therapy (22.8%) followed by need additional antimicrobial therapy (16.4%). In a multivariate logistic regression model, patients with comorbidities (Adjusted odds ratio (AOR): 1.84, 95% confidence interval (CI): 1.04– 3.27) and hospital stays exceeding one week (AOR=1.88, 95% CI: 1.08– 3.26) were predictors of antimicrobial use-related problems.Conclusion: Antimicrobial use-related problems were found in a significant proportion of pediatric patients. Addressing these issues necessitates collaborative efforts, emphasizing targeted education, strengthened antimicrobial stewardship, ensuring responsible antimicrobial use and enhancing pediatric care.Keywords: antimicrobial use-related problems, pediatric, Ethiopiahttps://www.dovepress.com/antimicrobial-use-related-problems-among-hospitalized-pediatric-patien-peer-reviewed-fulltext-article-IDRantimicrobial use-related problemspediatricethiopia. |
| spellingShingle | Gidey K Aregawi SG Hailu BY Asgedom SW Niriayo YL Antimicrobial Use-Related Problems Among Hospitalized Pediatric Patients: A Prospective Observational Study Infection and Drug Resistance antimicrobial use-related problems pediatric ethiopia. |
| title | Antimicrobial Use-Related Problems Among Hospitalized Pediatric Patients: A Prospective Observational Study |
| title_full | Antimicrobial Use-Related Problems Among Hospitalized Pediatric Patients: A Prospective Observational Study |
| title_fullStr | Antimicrobial Use-Related Problems Among Hospitalized Pediatric Patients: A Prospective Observational Study |
| title_full_unstemmed | Antimicrobial Use-Related Problems Among Hospitalized Pediatric Patients: A Prospective Observational Study |
| title_short | Antimicrobial Use-Related Problems Among Hospitalized Pediatric Patients: A Prospective Observational Study |
| title_sort | antimicrobial use related problems among hospitalized pediatric patients a prospective observational study |
| topic | antimicrobial use-related problems pediatric ethiopia. |
| url | https://www.dovepress.com/antimicrobial-use-related-problems-among-hospitalized-pediatric-patien-peer-reviewed-fulltext-article-IDR |
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