Androgen receptor-binding sites are highly mutated in prostate cancer
Androgen receptor (AR) mediated transcription is critical to prostate tumorigenesis and development. Here, utilising clinical whole genome sequencing data, the authors show that the non-coding AR binding sites on DNA are frequently mutated in prostate cancer potentially due to faulty base excision r...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14644-y |
| _version_ | 1818398578484183040 |
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| author | Tunç Morova Daniel R. McNeill Nada Lallous Mehmet Gönen Kush Dalal David M. Wilson Attila Gürsoy Özlem Keskin Nathan A. Lack |
| author_facet | Tunç Morova Daniel R. McNeill Nada Lallous Mehmet Gönen Kush Dalal David M. Wilson Attila Gürsoy Özlem Keskin Nathan A. Lack |
| author_sort | Tunç Morova |
| collection | DOAJ |
| description | Androgen receptor (AR) mediated transcription is critical to prostate tumorigenesis and development. Here, utilising clinical whole genome sequencing data, the authors show that the non-coding AR binding sites on DNA are frequently mutated in prostate cancer potentially due to faulty base excision repair mechanisms |
| first_indexed | 2024-12-14T07:07:01Z |
| format | Article |
| id | doaj.art-15a98cfbbcff421a8c1487325afd7722 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T07:07:01Z |
| publishDate | 2020-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-15a98cfbbcff421a8c1487325afd77222022-12-21T23:12:08ZengNature PortfolioNature Communications2041-17232020-02-0111111010.1038/s41467-020-14644-yAndrogen receptor-binding sites are highly mutated in prostate cancerTunç Morova0Daniel R. McNeill1Nada Lallous2Mehmet Gönen3Kush Dalal4David M. Wilson5Attila Gürsoy6Özlem Keskin7Nathan A. Lack8School of Medicine, Koç UniversityLaboratory of Molecular Gerontology, National Institute on Aging, NIHVancouver Prostate Centre, University of British ColumbiaSchool of Medicine, Koç UniversityVancouver Prostate Centre, University of British ColumbiaLaboratory of Molecular Gerontology, National Institute on Aging, NIHCollege of Engineering, Koç UniversityCollege of Engineering, Koç UniversitySchool of Medicine, Koç UniversityAndrogen receptor (AR) mediated transcription is critical to prostate tumorigenesis and development. Here, utilising clinical whole genome sequencing data, the authors show that the non-coding AR binding sites on DNA are frequently mutated in prostate cancer potentially due to faulty base excision repair mechanismshttps://doi.org/10.1038/s41467-020-14644-y |
| spellingShingle | Tunç Morova Daniel R. McNeill Nada Lallous Mehmet Gönen Kush Dalal David M. Wilson Attila Gürsoy Özlem Keskin Nathan A. Lack Androgen receptor-binding sites are highly mutated in prostate cancer Nature Communications |
| title | Androgen receptor-binding sites are highly mutated in prostate cancer |
| title_full | Androgen receptor-binding sites are highly mutated in prostate cancer |
| title_fullStr | Androgen receptor-binding sites are highly mutated in prostate cancer |
| title_full_unstemmed | Androgen receptor-binding sites are highly mutated in prostate cancer |
| title_short | Androgen receptor-binding sites are highly mutated in prostate cancer |
| title_sort | androgen receptor binding sites are highly mutated in prostate cancer |
| url | https://doi.org/10.1038/s41467-020-14644-y |
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