A new approach to endometrial cancer subtyping – a hope for a milestone in correct patient triaging
Endometrial cancer is the most common cancer of the female genital organs. For many years the prognosis was based on histopathological grade and type. The pathological identification of endometrial carcinomas included two types. Type I – endometrioid (EEC), similar to the endometrium – was character...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2023-09-01
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| Series: | Studia Medyczne |
| Subjects: | |
| Online Access: | https://www.termedia.pl/A-new-approach-to-endometrial-cancer-subtyping-a-hope-for-a-milestone-in-correct-patient-triaging,67,51330,1,1.html |
| _version_ | 1797450075191902208 |
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| author | Olga Adamczyk-Gruszka |
| author_facet | Olga Adamczyk-Gruszka |
| author_sort | Olga Adamczyk-Gruszka |
| collection | DOAJ |
| description | Endometrial cancer is the most common cancer of the female genital organs. For many years the prognosis was based on histopathological grade and type. The pathological identification of endometrial carcinomas included two types. Type I – endometrioid (EEC), similar to the endometrium – was characterized by genetic predisposition, obesity, polycystic ovary syndrome, anovulatory cycles, and irregular menstruation resulting from hyperestrogenism, which is the main predisposing factor for the development of type I EC. Type II included serous, clear cell, and undifferentiated carcinomas. Here were observed older patient’s age, higher clinical stage to compare with non-endometrioid histology, and finally poorer prognosis. The Cancer Genome Atlas (TCGA) study found mutations in several endometrioid and serous cancer genes. The TCGA has identified four molecular subclasses based on somatic mutation burden and copy number variations. Recent data show the prognostic value of TCGA subclasses because they correlate with patient survival. |
| first_indexed | 2024-03-09T14:34:20Z |
| format | Article |
| id | doaj.art-15a9f88f2e504f4c9c7e7c945633d8c4 |
| institution | Directory Open Access Journal |
| issn | 1899-1874 2300-6722 |
| language | English |
| last_indexed | 2024-03-09T14:34:20Z |
| publishDate | 2023-09-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Studia Medyczne |
| spelling | doaj.art-15a9f88f2e504f4c9c7e7c945633d8c42023-11-27T12:47:16ZengTermedia Publishing HouseStudia Medyczne1899-18742300-67222023-09-0139326727110.5114/ms.2023.13088251330A new approach to endometrial cancer subtyping – a hope for a milestone in correct patient triagingOlga Adamczyk-GruszkaEndometrial cancer is the most common cancer of the female genital organs. For many years the prognosis was based on histopathological grade and type. The pathological identification of endometrial carcinomas included two types. Type I – endometrioid (EEC), similar to the endometrium – was characterized by genetic predisposition, obesity, polycystic ovary syndrome, anovulatory cycles, and irregular menstruation resulting from hyperestrogenism, which is the main predisposing factor for the development of type I EC. Type II included serous, clear cell, and undifferentiated carcinomas. Here were observed older patient’s age, higher clinical stage to compare with non-endometrioid histology, and finally poorer prognosis. The Cancer Genome Atlas (TCGA) study found mutations in several endometrioid and serous cancer genes. The TCGA has identified four molecular subclasses based on somatic mutation burden and copy number variations. Recent data show the prognostic value of TCGA subclasses because they correlate with patient survival.https://www.termedia.pl/A-new-approach-to-endometrial-cancer-subtyping-a-hope-for-a-milestone-in-correct-patient-triaging,67,51330,1,1.htmlgenomics pathology oncology endometrial cancer stage. |
| spellingShingle | Olga Adamczyk-Gruszka A new approach to endometrial cancer subtyping – a hope for a milestone in correct patient triaging Studia Medyczne genomics pathology oncology endometrial cancer stage. |
| title | A new approach to endometrial cancer subtyping – a hope for a milestone in correct patient triaging |
| title_full | A new approach to endometrial cancer subtyping – a hope for a milestone in correct patient triaging |
| title_fullStr | A new approach to endometrial cancer subtyping – a hope for a milestone in correct patient triaging |
| title_full_unstemmed | A new approach to endometrial cancer subtyping – a hope for a milestone in correct patient triaging |
| title_short | A new approach to endometrial cancer subtyping – a hope for a milestone in correct patient triaging |
| title_sort | a new approach to endometrial cancer subtyping a hope for a milestone in correct patient triaging |
| topic | genomics pathology oncology endometrial cancer stage. |
| url | https://www.termedia.pl/A-new-approach-to-endometrial-cancer-subtyping-a-hope-for-a-milestone-in-correct-patient-triaging,67,51330,1,1.html |
| work_keys_str_mv | AT olgaadamczykgruszka anewapproachtoendometrialcancersubtypingahopeforamilestoneincorrectpatienttriaging |