Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms
Vessel wall enhancement (VWE) in contrast-enhanced magnetic resonance imaging (MRI) is a potential biomarker for intracranial aneurysm (IA) risk stratification. In this study, we investigated the relationship between VWE features, risk metrics, morphology and hemodynamics in 41 unruptured aneurysms....
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| Format: | Article |
| Language: | English |
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The Royal Society
2021-11-01
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| Series: | Royal Society Open Science |
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| Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsos.211119 |
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| author | Sricharan S. Veeturi Hamidreza Rajabzadeh-Oghaz Nándor K. Pintér Muhammad Waqas David M. Hasan Kenneth V. Snyder Adnan H. Siddiqui Vincent M. Tutino |
| author_facet | Sricharan S. Veeturi Hamidreza Rajabzadeh-Oghaz Nándor K. Pintér Muhammad Waqas David M. Hasan Kenneth V. Snyder Adnan H. Siddiqui Vincent M. Tutino |
| author_sort | Sricharan S. Veeturi |
| collection | DOAJ |
| description | Vessel wall enhancement (VWE) in contrast-enhanced magnetic resonance imaging (MRI) is a potential biomarker for intracranial aneurysm (IA) risk stratification. In this study, we investigated the relationship between VWE features, risk metrics, morphology and hemodynamics in 41 unruptured aneurysms. We reconstructed the IA geometries from MR angiography and mapped pituitary stalk-normalized MRI intensity on the aneurysm surface using an in-house tool. For each case, we calculated the maximum intensity (CRstalk) and IA risk (via size and the rupture resemblance score (RRS)). We performed correlation analysis to assess relationships between CRstalk and IA risk metrics (size and RRS), as well as each parameter encompassed in RRS, i.e. aneurysmal size ratio (SR), normalized wall shear stress (WSS) and oscillatory shear index. We found that CRstalk had a strong correlation (Pearson correlation coefficient, PCC = 0.630) with size and a moderate correlation (PCC = 0.472) with RRS, indicating an association between VWE and IA risk. Furthermore, CRstalk had a weak negative correlation with normalized WSS (PCC = −0.320) and a weak positive correlation with SR (PCC = 0.390). Local voxel-based analysis showed only a weak negative correlation between normalized WSS and contrast-enhanced MRI signal intensity (PCC = −0.240), suggesting that if low-normalized WSS induces enhancement-associated pathobiology, the effect is not localized. |
| first_indexed | 2024-12-20T18:57:35Z |
| format | Article |
| id | doaj.art-15aa92b2c96f4cb398032e5c19decf2e |
| institution | Directory Open Access Journal |
| issn | 2054-5703 |
| language | English |
| last_indexed | 2024-12-20T18:57:35Z |
| publishDate | 2021-11-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Royal Society Open Science |
| spelling | doaj.art-15aa92b2c96f4cb398032e5c19decf2e2022-12-21T19:29:29ZengThe Royal SocietyRoyal Society Open Science2054-57032021-11-0181110.1098/rsos.211119Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysmsSricharan S. Veeturi0Hamidreza Rajabzadeh-Oghaz1Nándor K. Pintér2Muhammad Waqas3David M. Hasan4Kenneth V. Snyder5Adnan H. Siddiqui6Vincent M. Tutino7Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USACanon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USADENT Neurologic Institute, Buffalo, NY, USACanon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USADepartment of Neurosurgery, University of Iowa Health Care, Iowa City, IA, USACanon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USACanon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USACanon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USAVessel wall enhancement (VWE) in contrast-enhanced magnetic resonance imaging (MRI) is a potential biomarker for intracranial aneurysm (IA) risk stratification. In this study, we investigated the relationship between VWE features, risk metrics, morphology and hemodynamics in 41 unruptured aneurysms. We reconstructed the IA geometries from MR angiography and mapped pituitary stalk-normalized MRI intensity on the aneurysm surface using an in-house tool. For each case, we calculated the maximum intensity (CRstalk) and IA risk (via size and the rupture resemblance score (RRS)). We performed correlation analysis to assess relationships between CRstalk and IA risk metrics (size and RRS), as well as each parameter encompassed in RRS, i.e. aneurysmal size ratio (SR), normalized wall shear stress (WSS) and oscillatory shear index. We found that CRstalk had a strong correlation (Pearson correlation coefficient, PCC = 0.630) with size and a moderate correlation (PCC = 0.472) with RRS, indicating an association between VWE and IA risk. Furthermore, CRstalk had a weak negative correlation with normalized WSS (PCC = −0.320) and a weak positive correlation with SR (PCC = 0.390). Local voxel-based analysis showed only a weak negative correlation between normalized WSS and contrast-enhanced MRI signal intensity (PCC = −0.240), suggesting that if low-normalized WSS induces enhancement-associated pathobiology, the effect is not localized.https://royalsocietypublishing.org/doi/10.1098/rsos.211119cerebral aneurysmcomputational fluid dynamicshemodynamicsvessel wall enhancementmagnetic resonance imaging |
| spellingShingle | Sricharan S. Veeturi Hamidreza Rajabzadeh-Oghaz Nándor K. Pintér Muhammad Waqas David M. Hasan Kenneth V. Snyder Adnan H. Siddiqui Vincent M. Tutino Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms Royal Society Open Science cerebral aneurysm computational fluid dynamics hemodynamics vessel wall enhancement magnetic resonance imaging |
| title | Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms |
| title_full | Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms |
| title_fullStr | Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms |
| title_full_unstemmed | Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms |
| title_short | Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms |
| title_sort | aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms |
| topic | cerebral aneurysm computational fluid dynamics hemodynamics vessel wall enhancement magnetic resonance imaging |
| url | https://royalsocietypublishing.org/doi/10.1098/rsos.211119 |
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