Comprehensive strategy for identifying extracellular vesicle surface proteins as biomarkers for chronic kidney disease
Chronic kidney disease (CKD) poses a significant health burden worldwide. Especially, obesity-induced chronic kidney disease (OCKD) is associated with a lack of accuracy in disease diagnostic methods. The identification of reliable biomarkers for the early diagnosis and monitoring of CKD and OCKD is...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2024.1328362/full |
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| author | Nahuel Aquiles Garcia Hernan Gonzalez-King Maiken Mellergaard Maiken Mellergaard Soumyalekshmi Nair Carlos Salomon Aase Handberg Aase Handberg |
| author_facet | Nahuel Aquiles Garcia Hernan Gonzalez-King Maiken Mellergaard Maiken Mellergaard Soumyalekshmi Nair Carlos Salomon Aase Handberg Aase Handberg |
| author_sort | Nahuel Aquiles Garcia |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) poses a significant health burden worldwide. Especially, obesity-induced chronic kidney disease (OCKD) is associated with a lack of accuracy in disease diagnostic methods. The identification of reliable biomarkers for the early diagnosis and monitoring of CKD and OCKD is crucial for improving patient outcomes. Extracellular vesicles (EVs) have emerged as potential biomarkers in the context of CKD. In this review, we focused on the role of EVs as potential biomarkers in CKD and OCKD and developed a comprehensive list of EV membrane proteins that could aid in the diagnosis and monitoring of the disease. To assemble our list, we employed a multi-step strategy. Initially, we conducted a thorough review of the literature on EV protein biomarkers in kidney diseases. Additionally, we explored papers investigating circulating proteins as biomarkers in kidney diseases. To further refine our list, we utilized the EV database Vesiclepedia.org to evaluate the qualifications of each identified protein. Furthermore, we consulted the Human Protein Atlas to assess the localization of these candidates, with a particular focus on membrane proteins. By integrating the information from the reviewed literature, Vesiclepedia.org, and the Human Protein Atlas, we compiled a comprehensive list of potential EV membrane protein biomarkers for CKD and OCKD. Overall, our review underscores the potential of EVs as biomarkers in the field of CKD research, providing a foundation for future studies aimed at improving CKD and OCKD diagnosis and treatment. |
| first_indexed | 2024-03-08T05:30:36Z |
| format | Article |
| id | doaj.art-15ad1221eb374fb6a55396cc01a027f0 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-08T05:30:36Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-15ad1221eb374fb6a55396cc01a027f02024-02-06T05:01:44ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2024-02-011510.3389/fphys.2024.13283621328362Comprehensive strategy for identifying extracellular vesicle surface proteins as biomarkers for chronic kidney diseaseNahuel Aquiles Garcia0Hernan Gonzalez-King1Maiken Mellergaard2Maiken Mellergaard3Soumyalekshmi Nair4Carlos Salomon5Aase Handberg6Aase Handberg7GECORP, Buenos Aires, ArgentinaResearch and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, SwedenDepartment of Clinical Biochemistry, Aalborg University Hospital, Aalborg, DenmarkDepartment of Clinical Medicine, The Faculty of Medicine, Aalborg University, Aalborg, DenmarkTranslational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group, University of Queensland, Brisbane, QLD, AustraliaTranslational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group, University of Queensland, Brisbane, QLD, AustraliaDepartment of Clinical Biochemistry, Aalborg University Hospital, Aalborg, DenmarkDepartment of Clinical Medicine, The Faculty of Medicine, Aalborg University, Aalborg, DenmarkChronic kidney disease (CKD) poses a significant health burden worldwide. Especially, obesity-induced chronic kidney disease (OCKD) is associated with a lack of accuracy in disease diagnostic methods. The identification of reliable biomarkers for the early diagnosis and monitoring of CKD and OCKD is crucial for improving patient outcomes. Extracellular vesicles (EVs) have emerged as potential biomarkers in the context of CKD. In this review, we focused on the role of EVs as potential biomarkers in CKD and OCKD and developed a comprehensive list of EV membrane proteins that could aid in the diagnosis and monitoring of the disease. To assemble our list, we employed a multi-step strategy. Initially, we conducted a thorough review of the literature on EV protein biomarkers in kidney diseases. Additionally, we explored papers investigating circulating proteins as biomarkers in kidney diseases. To further refine our list, we utilized the EV database Vesiclepedia.org to evaluate the qualifications of each identified protein. Furthermore, we consulted the Human Protein Atlas to assess the localization of these candidates, with a particular focus on membrane proteins. By integrating the information from the reviewed literature, Vesiclepedia.org, and the Human Protein Atlas, we compiled a comprehensive list of potential EV membrane protein biomarkers for CKD and OCKD. Overall, our review underscores the potential of EVs as biomarkers in the field of CKD research, providing a foundation for future studies aimed at improving CKD and OCKD diagnosis and treatment.https://www.frontiersin.org/articles/10.3389/fphys.2024.1328362/fullextracellular vesicleschronic kidney diseaseobesitysurface proteinsbiomarkers |
| spellingShingle | Nahuel Aquiles Garcia Hernan Gonzalez-King Maiken Mellergaard Maiken Mellergaard Soumyalekshmi Nair Carlos Salomon Aase Handberg Aase Handberg Comprehensive strategy for identifying extracellular vesicle surface proteins as biomarkers for chronic kidney disease Frontiers in Physiology extracellular vesicles chronic kidney disease obesity surface proteins biomarkers |
| title | Comprehensive strategy for identifying extracellular vesicle surface proteins as biomarkers for chronic kidney disease |
| title_full | Comprehensive strategy for identifying extracellular vesicle surface proteins as biomarkers for chronic kidney disease |
| title_fullStr | Comprehensive strategy for identifying extracellular vesicle surface proteins as biomarkers for chronic kidney disease |
| title_full_unstemmed | Comprehensive strategy for identifying extracellular vesicle surface proteins as biomarkers for chronic kidney disease |
| title_short | Comprehensive strategy for identifying extracellular vesicle surface proteins as biomarkers for chronic kidney disease |
| title_sort | comprehensive strategy for identifying extracellular vesicle surface proteins as biomarkers for chronic kidney disease |
| topic | extracellular vesicles chronic kidney disease obesity surface proteins biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2024.1328362/full |
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