Increased Dopamine Type 2 Gene Expression in the Dorsal Striatum in Individuals With Autism Spectrum Disorder Suggests Alterations in Indirect Pathway Signaling and Circuitry

Increased Dopamine Type 2 Gene Expression in the Dorsal Striatum in Individuals With Autism Spectrum Disorder Suggests Alterations in Indirect Pathway Signaling and Circuitry

Autism spectrum disorder (ASD) is behaviorally defined and diagnosed by delayed and/or impeded language, stereotyped repetitive behaviors, and difficulties with social interactions. Additionally, there are disruptions in motor processing, which includes the intent to execute movements, interrupted/i...

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Bibliographic Details
Main Authors: Cheryl Brandenburg, Jean-Jacques Soghomonian, Kunzhong Zhang, Ina Sulkaj, Brianna Randolph, Marissa Kachadoorian, Gene J. Blatt
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
autism spectrum disorder
dopamine
GABA
basal ganglia
indirect pathway
risperidone
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.577858/full

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