The Competitive Absorption by the Gut Microbiome Suggests the First-Order Absorption Kinetics of Caffeine
In the literature archive, the intestinal microbiome is now considered as a discrete organ system. Despite living symbiotically with the human body, the gut microbiome is represented as potential drug targets because of its ability to modify the pharmacokinetics of orally administered drugs. Structu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-08-01
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| Series: | Dose-Response |
| Online Access: | https://doi.org/10.1177/15593258211033111 |
| _version_ | 1819086763684003840 |
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| author | Imran Mukhtar Arslan Iftikhar Muhammad Imran Muhammad Umar Ijaz Shahzad Irfan Haseeb Anwar |
| author_facet | Imran Mukhtar Arslan Iftikhar Muhammad Imran Muhammad Umar Ijaz Shahzad Irfan Haseeb Anwar |
| author_sort | Imran Mukhtar |
| collection | DOAJ |
| description | In the literature archive, the intestinal microbiome is now considered as a discrete organ system. Despite living symbiotically with the human body, the gut microbiome is represented as potential drug targets because of its ability to modify the pharmacokinetics of orally administered drugs. Structural biology analysis indicates the existence of homology between transport proteins of microbial cells and membranes of enterocytes. It is speculated that structural similarity in the protein transporters may provoke an unwanted phenomenon of drug uptake by the gut microbiome present in the small intestine of the host. Considering this hypothesis, we analyzed the absorbance of orally administered caffeine by the gut microbiota in in vivo albino rat model through the RP-HPLC-UV approach. Microbiome absorbed the caffeine maximally at 2 hours and minimally at 5 hours post-drug administration following first-order absorption kinetics in a nonlinear way. Drug absorbance of microbial pellet and percent dose recovery was found significantly higher ( P ≤ .05) at 2 hours post-administration as compared to all other groups. As speculated, our findings advocated the phenomenon that the gut microbiome influences the absorption of caffeine molecules. Members of the gut microbiome exhibited grouped behavior following first-order absorption kinetics in a nonlinear pattern. |
| first_indexed | 2024-12-21T21:25:25Z |
| format | Article |
| id | doaj.art-15b5520c4f3a43128008d74c13a60ae0 |
| institution | Directory Open Access Journal |
| issn | 1559-3258 |
| language | English |
| last_indexed | 2024-12-21T21:25:25Z |
| publishDate | 2021-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Dose-Response |
| spelling | doaj.art-15b5520c4f3a43128008d74c13a60ae02022-12-21T18:49:46ZengSAGE PublishingDose-Response1559-32582021-08-011910.1177/15593258211033111The Competitive Absorption by the Gut Microbiome Suggests the First-Order Absorption Kinetics of CaffeineImran MukhtarArslan IftikharMuhammad ImranMuhammad Umar IjazShahzad IrfanHaseeb AnwarIn the literature archive, the intestinal microbiome is now considered as a discrete organ system. Despite living symbiotically with the human body, the gut microbiome is represented as potential drug targets because of its ability to modify the pharmacokinetics of orally administered drugs. Structural biology analysis indicates the existence of homology between transport proteins of microbial cells and membranes of enterocytes. It is speculated that structural similarity in the protein transporters may provoke an unwanted phenomenon of drug uptake by the gut microbiome present in the small intestine of the host. Considering this hypothesis, we analyzed the absorbance of orally administered caffeine by the gut microbiota in in vivo albino rat model through the RP-HPLC-UV approach. Microbiome absorbed the caffeine maximally at 2 hours and minimally at 5 hours post-drug administration following first-order absorption kinetics in a nonlinear way. Drug absorbance of microbial pellet and percent dose recovery was found significantly higher ( P ≤ .05) at 2 hours post-administration as compared to all other groups. As speculated, our findings advocated the phenomenon that the gut microbiome influences the absorption of caffeine molecules. Members of the gut microbiome exhibited grouped behavior following first-order absorption kinetics in a nonlinear pattern.https://doi.org/10.1177/15593258211033111 |
| spellingShingle | Imran Mukhtar Arslan Iftikhar Muhammad Imran Muhammad Umar Ijaz Shahzad Irfan Haseeb Anwar The Competitive Absorption by the Gut Microbiome Suggests the First-Order Absorption Kinetics of Caffeine Dose-Response |
| title | The Competitive Absorption by the Gut Microbiome Suggests the First-Order Absorption Kinetics of Caffeine |
| title_full | The Competitive Absorption by the Gut Microbiome Suggests the First-Order Absorption Kinetics of Caffeine |
| title_fullStr | The Competitive Absorption by the Gut Microbiome Suggests the First-Order Absorption Kinetics of Caffeine |
| title_full_unstemmed | The Competitive Absorption by the Gut Microbiome Suggests the First-Order Absorption Kinetics of Caffeine |
| title_short | The Competitive Absorption by the Gut Microbiome Suggests the First-Order Absorption Kinetics of Caffeine |
| title_sort | competitive absorption by the gut microbiome suggests the first order absorption kinetics of caffeine |
| url | https://doi.org/10.1177/15593258211033111 |
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