Ceramic materials for 3D printing of biomimetic bone scaffolds – Current state-of-the-art & future perspectives
Ceramic bone implants have potential properties ideal for long-term implantation applications. On comparison with other materials, ceramic biomaterials have advantages such as biocompatibility, low cost, osteoconductivity, osteoinductivity, corrosion resistance, and can be made into various shapes w...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523004793 |
| _version_ | 1797793985249411072 |
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| author | Harshavardhan Budharaju Shruthy Suresh Muthu Parkkavi Sekar Brigita De Vega Swaminathan Sethuraman Dhakshinamoorthy Sundaramurthi Deepak M. Kalaskar |
| author_facet | Harshavardhan Budharaju Shruthy Suresh Muthu Parkkavi Sekar Brigita De Vega Swaminathan Sethuraman Dhakshinamoorthy Sundaramurthi Deepak M. Kalaskar |
| author_sort | Harshavardhan Budharaju |
| collection | DOAJ |
| description | Ceramic bone implants have potential properties ideal for long-term implantation applications. On comparison with other materials, ceramic biomaterials have advantages such as biocompatibility, low cost, osteoconductivity, osteoinductivity, corrosion resistance, and can be made into various shapes with desired surface properties. Among transplantation surgeries, bone transplantation is the second largest in the globe after blood transfusion which is an indication for rising hope on the potential treatment options for bone. 3D printing is one of the most advanced fabrication techniques to create customized bone implants using materials such as ceramics and their composites. Developing bone scaffolds that precisely recapitulate the mechanical properties and other biological functions of bone remains a major challenge. However, extensive research on ceramic biomaterials have resulted in the successful 3D printing of complex bony designs with >50% porosity with cortical bone mechanical properties. This review critically analyses the use of various 3D printing techniques to fabricate ceramic bone scaffolds. Further, various natural and synthetic ceramic materials for producing customized ceramic implants are discussed along with potential clinical applications. Finally, a list of companies that offer customized 3D printed implants and the future on clinical translation of 3D printed ceramic bone implants are outlined. |
| first_indexed | 2024-03-13T02:56:13Z |
| format | Article |
| id | doaj.art-15b806aaae3d40df8473289952097fe4 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-03-13T02:56:13Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-15b806aaae3d40df8473289952097fe42023-06-28T04:28:41ZengElsevierMaterials & Design0264-12752023-07-01231112064Ceramic materials for 3D printing of biomimetic bone scaffolds – Current state-of-the-art & future perspectivesHarshavardhan Budharaju0Shruthy Suresh1Muthu Parkkavi Sekar2Brigita De Vega3Swaminathan Sethuraman4Dhakshinamoorthy Sundaramurthi5Deepak M. Kalaskar6Tissue Engineering & Additive Manufacturing (TEAM) Lab, ABCDE Innovation Centre, Centre for Nanotechnology & Advanced Biomaterials, School of Chemical & Biotechnology, SASTRA Deemed University, Thanjavur 613 401, Tamil Nadu, IndiaTissue Engineering & Additive Manufacturing (TEAM) Lab, ABCDE Innovation Centre, Centre for Nanotechnology & Advanced Biomaterials, School of Chemical & Biotechnology, SASTRA Deemed University, Thanjavur 613 401, Tamil Nadu, IndiaTissue Engineering & Additive Manufacturing (TEAM) Lab, ABCDE Innovation Centre, Centre for Nanotechnology & Advanced Biomaterials, School of Chemical & Biotechnology, SASTRA Deemed University, Thanjavur 613 401, Tamil Nadu, IndiaUCL Institute of Orthopaedics and Musculoskeletal Sciences, Division of Surgery and Interventional Science, Royal National Orthopaedic Hospital, Brockley Hill HA7 4LP, United KingdomTissue Engineering & Additive Manufacturing (TEAM) Lab, ABCDE Innovation Centre, Centre for Nanotechnology & Advanced Biomaterials, School of Chemical & Biotechnology, SASTRA Deemed University, Thanjavur 613 401, Tamil Nadu, IndiaTissue Engineering & Additive Manufacturing (TEAM) Lab, ABCDE Innovation Centre, Centre for Nanotechnology & Advanced Biomaterials, School of Chemical & Biotechnology, SASTRA Deemed University, Thanjavur 613 401, Tamil Nadu, India; Corresponding authors.UCL Institute of Orthopaedics and Musculoskeletal Sciences, Division of Surgery and Interventional Science, Royal National Orthopaedic Hospital, Brockley Hill HA7 4LP, United Kingdom; Corresponding authors.Ceramic bone implants have potential properties ideal for long-term implantation applications. On comparison with other materials, ceramic biomaterials have advantages such as biocompatibility, low cost, osteoconductivity, osteoinductivity, corrosion resistance, and can be made into various shapes with desired surface properties. Among transplantation surgeries, bone transplantation is the second largest in the globe after blood transfusion which is an indication for rising hope on the potential treatment options for bone. 3D printing is one of the most advanced fabrication techniques to create customized bone implants using materials such as ceramics and their composites. Developing bone scaffolds that precisely recapitulate the mechanical properties and other biological functions of bone remains a major challenge. However, extensive research on ceramic biomaterials have resulted in the successful 3D printing of complex bony designs with >50% porosity with cortical bone mechanical properties. This review critically analyses the use of various 3D printing techniques to fabricate ceramic bone scaffolds. Further, various natural and synthetic ceramic materials for producing customized ceramic implants are discussed along with potential clinical applications. Finally, a list of companies that offer customized 3D printed implants and the future on clinical translation of 3D printed ceramic bone implants are outlined.http://www.sciencedirect.com/science/article/pii/S0264127523004793CeramicsBone grafts3D printingBone tissue engineeringSynthetic bone scaffoldsHydroxyapatite |
| spellingShingle | Harshavardhan Budharaju Shruthy Suresh Muthu Parkkavi Sekar Brigita De Vega Swaminathan Sethuraman Dhakshinamoorthy Sundaramurthi Deepak M. Kalaskar Ceramic materials for 3D printing of biomimetic bone scaffolds – Current state-of-the-art & future perspectives Materials & Design Ceramics Bone grafts 3D printing Bone tissue engineering Synthetic bone scaffolds Hydroxyapatite |
| title | Ceramic materials for 3D printing of biomimetic bone scaffolds – Current state-of-the-art & future perspectives |
| title_full | Ceramic materials for 3D printing of biomimetic bone scaffolds – Current state-of-the-art & future perspectives |
| title_fullStr | Ceramic materials for 3D printing of biomimetic bone scaffolds – Current state-of-the-art & future perspectives |
| title_full_unstemmed | Ceramic materials for 3D printing of biomimetic bone scaffolds – Current state-of-the-art & future perspectives |
| title_short | Ceramic materials for 3D printing of biomimetic bone scaffolds – Current state-of-the-art & future perspectives |
| title_sort | ceramic materials for 3d printing of biomimetic bone scaffolds current state of the art amp future perspectives |
| topic | Ceramics Bone grafts 3D printing Bone tissue engineering Synthetic bone scaffolds Hydroxyapatite |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523004793 |
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