Traditional Chinese Medicine for Coronary Heart Disease: Clinical Evidence and Possible Mechanisms
Coronary heart disease (CHD) remains a major cause of mortality with a huge economic burden on healthcare worldwide. Here, we conducted a systematic review to investigate the efficacy and safety of Chinese herbal medicine (CHM) for CHD based on high-quality randomized controlled trials (RCTs) and su...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2019.00844/full |
| _version_ | 1818827504647929856 |
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| author | Ke-Jian Zhang Qun Zheng Peng-Chong Zhu Qiang Tong Zhuang Zhuang Jia-Zhen Zhu Xiao-Yi Bao Yue-Yue Huang Guo-Qing Zheng Yan Wang |
| author_facet | Ke-Jian Zhang Qun Zheng Peng-Chong Zhu Qiang Tong Zhuang Zhuang Jia-Zhen Zhu Xiao-Yi Bao Yue-Yue Huang Guo-Qing Zheng Yan Wang |
| author_sort | Ke-Jian Zhang |
| collection | DOAJ |
| description | Coronary heart disease (CHD) remains a major cause of mortality with a huge economic burden on healthcare worldwide. Here, we conducted a systematic review to investigate the efficacy and safety of Chinese herbal medicine (CHM) for CHD based on high-quality randomized controlled trials (RCTs) and summarized its possible mechanisms according to animal-based researches. 27 eligible studies were identified in eight database searches from inception to June 2018. The methodological quality was assessed using seven-item checklist recommended by Cochrane Collaboration. All the data were analyzed using Rev-Man 5.3 software. As a result, the score of study quality ranged from 4 to 7 points. Meta-analyses showed CHM can significantly reduce the incidence of myocardial infarction and percutaneous coronary intervention, and cardiovascular mortality (P < 0.05), and increase systolic function of heart, the ST-segment depression, and clinical efficacy (P < 0.05). Adverse events were reported in 11 studies, and CHMs were well tolerated in patients with CHD. In addition, CHM exerted cardioprotection for CHD, possibly altering multiple signal pathways through anti-inflammatory, anti-oxidation, anti-apoptosis, improving the circulation, and regulating energy metabolism. In conclusion, the evidence available from present study revealed that CHMs are beneficial for CHD and are generally safe. |
| first_indexed | 2024-12-19T00:44:37Z |
| format | Article |
| id | doaj.art-15b9b769e5ee4ef891d1dc96a56e1fad |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-19T00:44:37Z |
| publishDate | 2019-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-15b9b769e5ee4ef891d1dc96a56e1fad2022-12-21T20:44:19ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-08-011010.3389/fphar.2019.00844446704Traditional Chinese Medicine for Coronary Heart Disease: Clinical Evidence and Possible MechanismsKe-Jian Zhang0Qun Zheng1Peng-Chong Zhu2Qiang Tong3Zhuang Zhuang4Jia-Zhen Zhu5Xiao-Yi Bao6Yue-Yue Huang7Guo-Qing Zheng8Yan Wang9Department of Cardiology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Cardiology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Cardiology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Cardiology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Cardiology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Cardiology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Cardiology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Cardiology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Cardiology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaCoronary heart disease (CHD) remains a major cause of mortality with a huge economic burden on healthcare worldwide. Here, we conducted a systematic review to investigate the efficacy and safety of Chinese herbal medicine (CHM) for CHD based on high-quality randomized controlled trials (RCTs) and summarized its possible mechanisms according to animal-based researches. 27 eligible studies were identified in eight database searches from inception to June 2018. The methodological quality was assessed using seven-item checklist recommended by Cochrane Collaboration. All the data were analyzed using Rev-Man 5.3 software. As a result, the score of study quality ranged from 4 to 7 points. Meta-analyses showed CHM can significantly reduce the incidence of myocardial infarction and percutaneous coronary intervention, and cardiovascular mortality (P < 0.05), and increase systolic function of heart, the ST-segment depression, and clinical efficacy (P < 0.05). Adverse events were reported in 11 studies, and CHMs were well tolerated in patients with CHD. In addition, CHM exerted cardioprotection for CHD, possibly altering multiple signal pathways through anti-inflammatory, anti-oxidation, anti-apoptosis, improving the circulation, and regulating energy metabolism. In conclusion, the evidence available from present study revealed that CHMs are beneficial for CHD and are generally safe.https://www.frontiersin.org/article/10.3389/fphar.2019.00844/fullTraditional Chinese medicinecoronary heart diseasehigh-quality randomized controlled trialsclinical evidencepossible mechanismssystematic review |
| spellingShingle | Ke-Jian Zhang Qun Zheng Peng-Chong Zhu Qiang Tong Zhuang Zhuang Jia-Zhen Zhu Xiao-Yi Bao Yue-Yue Huang Guo-Qing Zheng Yan Wang Traditional Chinese Medicine for Coronary Heart Disease: Clinical Evidence and Possible Mechanisms Frontiers in Pharmacology Traditional Chinese medicine coronary heart disease high-quality randomized controlled trials clinical evidence possible mechanisms systematic review |
| title | Traditional Chinese Medicine for Coronary Heart Disease: Clinical Evidence and Possible Mechanisms |
| title_full | Traditional Chinese Medicine for Coronary Heart Disease: Clinical Evidence and Possible Mechanisms |
| title_fullStr | Traditional Chinese Medicine for Coronary Heart Disease: Clinical Evidence and Possible Mechanisms |
| title_full_unstemmed | Traditional Chinese Medicine for Coronary Heart Disease: Clinical Evidence and Possible Mechanisms |
| title_short | Traditional Chinese Medicine for Coronary Heart Disease: Clinical Evidence and Possible Mechanisms |
| title_sort | traditional chinese medicine for coronary heart disease clinical evidence and possible mechanisms |
| topic | Traditional Chinese medicine coronary heart disease high-quality randomized controlled trials clinical evidence possible mechanisms systematic review |
| url | https://www.frontiersin.org/article/10.3389/fphar.2019.00844/full |
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