Accuracy of 68Ga-PSMA PET-CT and PET-MRI in lymph node staging for localized prostate cancer
ABSTRACT Objective To evaluate the predictive value of positron emission computed tomography or magnetic resonance (PET-CT and PET-MRI) using gallium-68-labeled prostate-specific membrane antigen (68Ga-PSMA) in lymph node involvement in prostate cancer. Methods A retrospective study comprising 9...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Instituto Israelita de Ensino e Pesquisa Albert Einstein
2022-05-01
|
| Series: | Einstein (São Paulo) |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082022000100248&lng=en&tlng=en |
| _version_ | 1818212907464261632 |
|---|---|
| author | Álan Roger Gomes Barbosa Breno Santos Amaral Danilo Budib Lourenço Bianca Bianco Felipe Arakaki Gushiken Marcelo Apezzato Júlia Francisco Silva Marcelo Livorsi da Cunha Reneé Zon Filippi Ronaldo Hueb Baroni Gustavo Caserta Lemos Arie Carneiro |
| author_facet | Álan Roger Gomes Barbosa Breno Santos Amaral Danilo Budib Lourenço Bianca Bianco Felipe Arakaki Gushiken Marcelo Apezzato Júlia Francisco Silva Marcelo Livorsi da Cunha Reneé Zon Filippi Ronaldo Hueb Baroni Gustavo Caserta Lemos Arie Carneiro |
| author_sort | Álan Roger Gomes Barbosa |
| collection | DOAJ |
| description | ABSTRACT Objective To evaluate the predictive value of positron emission computed tomography or magnetic resonance (PET-CT and PET-MRI) using gallium-68-labeled prostate-specific membrane antigen (68Ga-PSMA) in lymph node involvement in prostate cancer. Methods A retrospective study comprising 91 patients diagnosed with prostate cancer between 2016 to 2020, who underwent 68Ga-PSMA PET-CT or PET-MRI for staging before prostatectomy. The patients were divided into Group 1, with 65 patients with satisfactory pathological lymph node analysis, and Group 2, with 91 patients representing the sum of patients with pathological lymph node analysis and those with postoperative prostate-specific antigen within 60 days after surgery. Receiver Operating Characteristic curves were used to assess accuracy of predictive capacity of imaging exams for lymph node involvement. Results Regarding local clinical staging, the groups showed similar results, and 50% were classified as staging T2a. The accuracy of 68Ga-PSMA PET-CT for prostate cancer lymph node staging was 86.5% (95%CI 0.74-0.94; p=0.06), with a sensitivity of 58.3% and specificity of 95%. The accuracy of 68Ga-PSMA PET-MRI was 84.6% (95%CI 0.69-0.94; p=0.09), with a sensitivity of 40% and specificity of 100%. Considering both 68Ga-PSMA PET-CT and PET-MRI, the accuracy was 85.7% (95%CI 0.76-0.92; p=0.015), with sensitivity of 50% and specificity of 97%. Conclusion The imaging tests 68Ga-PSMA PET-CT and PET-MRI were highly accurate to detect preoperative lymph node involvement, and could be useful tools to indicate the need for extended lymph node dissection during radical prostatectomy. |
| first_indexed | 2024-12-12T05:55:51Z |
| format | Article |
| id | doaj.art-15bca67af6254c3d862c18f1adba82e9 |
| institution | Directory Open Access Journal |
| issn | 2317-6385 |
| language | English |
| last_indexed | 2024-12-12T05:55:51Z |
| publishDate | 2022-05-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-15bca67af6254c3d862c18f1adba82e92022-12-22T00:35:34ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-63852022-05-012010.31744/einstein_journal/2022ao6599Accuracy of 68Ga-PSMA PET-CT and PET-MRI in lymph node staging for localized prostate cancerÁlan Roger Gomes Barbosahttps://orcid.org/0000-0001-9892-6458Breno Santos Amaralhttps://orcid.org/0000-0002-4586-8183Danilo Budib Lourençohttps://orcid.org/0000-0002-7536-1148Bianca Biancohttps://orcid.org/0000-0001-8669-3562Felipe Arakaki Gushikenhttps://orcid.org/0000-0002-5710-2599Marcelo Apezzatohttps://orcid.org/0000-0003-1068-6600Júlia Francisco Silvahttps://orcid.org/0000-0002-6169-3117Marcelo Livorsi da Cunhahttps://orcid.org/0000-0002-5416-5439Reneé Zon Filippihttps://orcid.org/0000-0002-1250-0876Ronaldo Hueb Baronihttps://orcid.org/0000-0001-8762-0875Gustavo Caserta Lemoshttps://orcid.org/0000-0001-8818-4964Arie Carneirohttps://orcid.org/0000-0002-0152-0513ABSTRACT Objective To evaluate the predictive value of positron emission computed tomography or magnetic resonance (PET-CT and PET-MRI) using gallium-68-labeled prostate-specific membrane antigen (68Ga-PSMA) in lymph node involvement in prostate cancer. Methods A retrospective study comprising 91 patients diagnosed with prostate cancer between 2016 to 2020, who underwent 68Ga-PSMA PET-CT or PET-MRI for staging before prostatectomy. The patients were divided into Group 1, with 65 patients with satisfactory pathological lymph node analysis, and Group 2, with 91 patients representing the sum of patients with pathological lymph node analysis and those with postoperative prostate-specific antigen within 60 days after surgery. Receiver Operating Characteristic curves were used to assess accuracy of predictive capacity of imaging exams for lymph node involvement. Results Regarding local clinical staging, the groups showed similar results, and 50% were classified as staging T2a. The accuracy of 68Ga-PSMA PET-CT for prostate cancer lymph node staging was 86.5% (95%CI 0.74-0.94; p=0.06), with a sensitivity of 58.3% and specificity of 95%. The accuracy of 68Ga-PSMA PET-MRI was 84.6% (95%CI 0.69-0.94; p=0.09), with a sensitivity of 40% and specificity of 100%. Considering both 68Ga-PSMA PET-CT and PET-MRI, the accuracy was 85.7% (95%CI 0.76-0.92; p=0.015), with sensitivity of 50% and specificity of 97%. Conclusion The imaging tests 68Ga-PSMA PET-CT and PET-MRI were highly accurate to detect preoperative lymph node involvement, and could be useful tools to indicate the need for extended lymph node dissection during radical prostatectomy.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082022000100248&lng=en&tlng=enProstatic neoplasmsLymph nodesProstatectomyData accuracyPositron emission tomography computed tomographyProstate-specific antigenGallium |
| spellingShingle | Álan Roger Gomes Barbosa Breno Santos Amaral Danilo Budib Lourenço Bianca Bianco Felipe Arakaki Gushiken Marcelo Apezzato Júlia Francisco Silva Marcelo Livorsi da Cunha Reneé Zon Filippi Ronaldo Hueb Baroni Gustavo Caserta Lemos Arie Carneiro Accuracy of 68Ga-PSMA PET-CT and PET-MRI in lymph node staging for localized prostate cancer Einstein (São Paulo) Prostatic neoplasms Lymph nodes Prostatectomy Data accuracy Positron emission tomography computed tomography Prostate-specific antigen Gallium |
| title | Accuracy of 68Ga-PSMA PET-CT and PET-MRI in lymph node staging for localized prostate cancer |
| title_full | Accuracy of 68Ga-PSMA PET-CT and PET-MRI in lymph node staging for localized prostate cancer |
| title_fullStr | Accuracy of 68Ga-PSMA PET-CT and PET-MRI in lymph node staging for localized prostate cancer |
| title_full_unstemmed | Accuracy of 68Ga-PSMA PET-CT and PET-MRI in lymph node staging for localized prostate cancer |
| title_short | Accuracy of 68Ga-PSMA PET-CT and PET-MRI in lymph node staging for localized prostate cancer |
| title_sort | accuracy of 68ga psma pet ct and pet mri in lymph node staging for localized prostate cancer |
| topic | Prostatic neoplasms Lymph nodes Prostatectomy Data accuracy Positron emission tomography computed tomography Prostate-specific antigen Gallium |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082022000100248&lng=en&tlng=en |
| work_keys_str_mv | AT alanrogergomesbarbosa accuracyof68gapsmapetctandpetmriinlymphnodestagingforlocalizedprostatecancer AT brenosantosamaral accuracyof68gapsmapetctandpetmriinlymphnodestagingforlocalizedprostatecancer AT danilobudiblourenco accuracyof68gapsmapetctandpetmriinlymphnodestagingforlocalizedprostatecancer AT biancabianco accuracyof68gapsmapetctandpetmriinlymphnodestagingforlocalizedprostatecancer AT felipearakakigushiken accuracyof68gapsmapetctandpetmriinlymphnodestagingforlocalizedprostatecancer AT marceloapezzato accuracyof68gapsmapetctandpetmriinlymphnodestagingforlocalizedprostatecancer AT juliafranciscosilva accuracyof68gapsmapetctandpetmriinlymphnodestagingforlocalizedprostatecancer AT marcelolivorsidacunha accuracyof68gapsmapetctandpetmriinlymphnodestagingforlocalizedprostatecancer AT reneezonfilippi accuracyof68gapsmapetctandpetmriinlymphnodestagingforlocalizedprostatecancer AT ronaldohuebbaroni accuracyof68gapsmapetctandpetmriinlymphnodestagingforlocalizedprostatecancer AT gustavocasertalemos accuracyof68gapsmapetctandpetmriinlymphnodestagingforlocalizedprostatecancer AT ariecarneiro accuracyof68gapsmapetctandpetmriinlymphnodestagingforlocalizedprostatecancer |