NRF2 and STAT3: friends or foes in carcinogenesis?
Abstract NRF2 is a transcription factor that plays a pivotal role in carcinogenesis, also through the interaction with several pro-survival pathways. NRF2 controls the transcription of detoxification enzymes and a variety of other molecules impinging in several key biological processes. This perspec...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2023-03-01
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| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-023-00644-z |
| _version_ | 1797853698359033856 |
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| author | Andrea Arena Maria Anele Romeo Rossella Benedetti Maria Saveria Gilardini Montani Roberta Santarelli Roberta Gonnella Gabriella D’Orazi Mara Cirone |
| author_facet | Andrea Arena Maria Anele Romeo Rossella Benedetti Maria Saveria Gilardini Montani Roberta Santarelli Roberta Gonnella Gabriella D’Orazi Mara Cirone |
| author_sort | Andrea Arena |
| collection | DOAJ |
| description | Abstract NRF2 is a transcription factor that plays a pivotal role in carcinogenesis, also through the interaction with several pro-survival pathways. NRF2 controls the transcription of detoxification enzymes and a variety of other molecules impinging in several key biological processes. This perspective will focus on the complex interplay of NRF2 with STAT3, another transcription factor often aberrantly activated in cancer and driving tumorigenesis as well as immune suppression. Both NRF2 and STAT3 can be regulated by ER stress/UPR activation and their cross-talk influences and is influenced by autophagy and cytokines, contributing to shape the microenvironment, and both control the execution of DDR, also by regulating the expression of HSPs. Given the importance of these transcription factors, more investigations aimed at better elucidating the outcome of their networking could help to discover new and more efficacious strategies to fight cancer. |
| first_indexed | 2024-04-09T19:54:55Z |
| format | Article |
| id | doaj.art-15bcc674e8b744f682571bc4ce72aa38 |
| institution | Directory Open Access Journal |
| issn | 2730-6011 |
| language | English |
| last_indexed | 2024-04-09T19:54:55Z |
| publishDate | 2023-03-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj.art-15bcc674e8b744f682571bc4ce72aa382023-04-03T05:31:49ZengSpringerDiscover Oncology2730-60112023-03-0114111010.1007/s12672-023-00644-zNRF2 and STAT3: friends or foes in carcinogenesis?Andrea Arena0Maria Anele Romeo1Rossella Benedetti2Maria Saveria Gilardini Montani3Roberta Santarelli4Roberta Gonnella5Gabriella D’Orazi6Mara Cirone7Department of Experimental Medicine, Sapienza University of RomeDepartment of Experimental Medicine, Sapienza University of RomeDepartment of Experimental Medicine, Sapienza University of RomeDepartment of Experimental Medicine, Sapienza University of RomeDepartment of Experimental Medicine, Sapienza University of RomeDepartment of Experimental Medicine, Sapienza University of RomeDepartment of Neurosciences, Imaging and Clinical Sciences, University “G. D’Annunzio”Department of Experimental Medicine, Sapienza University of RomeAbstract NRF2 is a transcription factor that plays a pivotal role in carcinogenesis, also through the interaction with several pro-survival pathways. NRF2 controls the transcription of detoxification enzymes and a variety of other molecules impinging in several key biological processes. This perspective will focus on the complex interplay of NRF2 with STAT3, another transcription factor often aberrantly activated in cancer and driving tumorigenesis as well as immune suppression. Both NRF2 and STAT3 can be regulated by ER stress/UPR activation and their cross-talk influences and is influenced by autophagy and cytokines, contributing to shape the microenvironment, and both control the execution of DDR, also by regulating the expression of HSPs. Given the importance of these transcription factors, more investigations aimed at better elucidating the outcome of their networking could help to discover new and more efficacious strategies to fight cancer.https://doi.org/10.1007/s12672-023-00644-zNRF2STAT3p62/SQSTM1CytokinesDDR |
| spellingShingle | Andrea Arena Maria Anele Romeo Rossella Benedetti Maria Saveria Gilardini Montani Roberta Santarelli Roberta Gonnella Gabriella D’Orazi Mara Cirone NRF2 and STAT3: friends or foes in carcinogenesis? Discover Oncology NRF2 STAT3 p62/SQSTM1 Cytokines DDR |
| title | NRF2 and STAT3: friends or foes in carcinogenesis? |
| title_full | NRF2 and STAT3: friends or foes in carcinogenesis? |
| title_fullStr | NRF2 and STAT3: friends or foes in carcinogenesis? |
| title_full_unstemmed | NRF2 and STAT3: friends or foes in carcinogenesis? |
| title_short | NRF2 and STAT3: friends or foes in carcinogenesis? |
| title_sort | nrf2 and stat3 friends or foes in carcinogenesis |
| topic | NRF2 STAT3 p62/SQSTM1 Cytokines DDR |
| url | https://doi.org/10.1007/s12672-023-00644-z |
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