HPV Type Distribution in HIV Positive and Negative Women With or Without Cervical Dysplasia or Cancer in East Africa
BackgroundWomen living with HIV in sub-Saharan Africa are at increased risk to develop cervical cancer (CC), which is caused by persistent infection with 13 oncogenic human papilloma viruses (HR-HPVs). It is important to accurately identify and target HIV-positive women at highest risk to develop CC...
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Oncology |
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| author | Ruby Mcharo Tessa Lennemann Tessa Lennemann John France Liseth Torres Mercè Garí Wilbert Mbuya Wilbert Mbuya Wolfram Mwalongo Anifrid Mahenge Asli Bauer Asli Bauer Jonathan Mnkai Laura Glasmeyer Mona Judick Matilda Paul Nicolas Schroeder Bareke Msomba Magreth Sembo Nhamo Chiwerengo Michael Hoelscher Michael Hoelscher Otto Geisenberger Otto Geisenberger Ralph J. Lelle Elmar Saathoff Elmar Saathoff Leonard Maboko Mkunde Chachage Mkunde Chachage Mkunde Chachage Arne Kroidl Arne Kroidl Christof Geldmacher Christof Geldmacher |
| author_facet | Ruby Mcharo Tessa Lennemann Tessa Lennemann John France Liseth Torres Mercè Garí Wilbert Mbuya Wilbert Mbuya Wolfram Mwalongo Anifrid Mahenge Asli Bauer Asli Bauer Jonathan Mnkai Laura Glasmeyer Mona Judick Matilda Paul Nicolas Schroeder Bareke Msomba Magreth Sembo Nhamo Chiwerengo Michael Hoelscher Michael Hoelscher Otto Geisenberger Otto Geisenberger Ralph J. Lelle Elmar Saathoff Elmar Saathoff Leonard Maboko Mkunde Chachage Mkunde Chachage Mkunde Chachage Arne Kroidl Arne Kroidl Christof Geldmacher Christof Geldmacher |
| author_sort | Ruby Mcharo |
| collection | DOAJ |
| description | BackgroundWomen living with HIV in sub-Saharan Africa are at increased risk to develop cervical cancer (CC), which is caused by persistent infection with 13 oncogenic human papilloma viruses (HR-HPVs). It is important to accurately identify and target HIV-positive women at highest risk to develop CC for early therapeutic intervention.MethodsA total of 2,134 HIV+ and HIV− women from South-West Tanzania were prospectively screened for cervical cancer and precancerous lesions. Women with cervical cancer (n=236), high- and low-grade squamous intraepithelial lesions (HSIL: n=68, LSIL: n=74), and without lesion (n=426) underwent high-resolution HPV genotyping.ResultsEighty percent of women who were diagnosed with HSIL or LSIL were living with HIV. Any lesion, young age, HIV status, and depleted CD4 T cell counts were independent risk factors for HPV infections, which were predominantly caused by HR-HPV types. While multiple HR-HPV type infections were predominant in HIV+ women with HSIL, single-type infections predominated in HIV+ CC cases (p=0.0006). HPV16, 18, and 45 accounted for 85% (68/80) and 75% (82/110) of HIV+ and HIV− CC cases, respectively. Of note, HPV35, the most frequent HPV type in HSIL-positive women living with HIV, was rarely detected as a single-type infection in HSIL and cancer cases.ConclusionHPV16, 18, and 45 should receive special attention for molecular diagnostic algorithms during CC prevention programs for HIV+ women from sub-Saharan Africa. HPV35 may have a high potential to induce HSIL in women living with HIV, but less potential to cause cervical cancer in single-type infections. |
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| language | English |
| last_indexed | 2024-12-14T14:33:38Z |
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| series | Frontiers in Oncology |
| spelling | doaj.art-15bddb881e4d4fdc8d763d693956f2e82022-12-21T22:57:44ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-11-011110.3389/fonc.2021.763717763717HPV Type Distribution in HIV Positive and Negative Women With or Without Cervical Dysplasia or Cancer in East AfricaRuby Mcharo0Tessa Lennemann1Tessa Lennemann2John France3Liseth Torres4Mercè Garí5Wilbert Mbuya6Wilbert Mbuya7Wolfram Mwalongo8Anifrid Mahenge9Asli Bauer10Asli Bauer11Jonathan Mnkai12Laura Glasmeyer13Mona Judick14Matilda Paul15Nicolas Schroeder16Bareke Msomba17Magreth Sembo18Nhamo Chiwerengo19Michael Hoelscher20Michael Hoelscher21Otto Geisenberger22Otto Geisenberger23Ralph J. Lelle24Elmar Saathoff25Elmar Saathoff26Leonard Maboko27Mkunde Chachage28Mkunde Chachage29Mkunde Chachage30Arne Kroidl31Arne Kroidl32Christof Geldmacher33Christof Geldmacher34National Institute for Medical Research (NIMR)-Mbeya Medical Research Center (MMRC), Mbeya, TanzaniaNational Institute for Medical Research (NIMR)-Mbeya Medical Research Center (MMRC), Mbeya, TanzaniaDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, GermanyDepartment of Obstetrics and Gynecology, Mbeya Zonal Referral Hospital, Mbeya, TanzaniaNational Institute for Medical Research (NIMR)-Mbeya Medical Research Center (MMRC), Mbeya, TanzaniaInstitute of Computational Biology, Helmholtz Zentrum München, Neuherberg, GermanyNational Institute for Medical Research (NIMR)-Mbeya Medical Research Center (MMRC), Mbeya, TanzaniaDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, GermanyNational Institute for Medical Research (NIMR)-Mbeya Medical Research Center (MMRC), Mbeya, TanzaniaNational Institute for Medical Research (NIMR)-Mbeya Medical Research Center (MMRC), Mbeya, TanzaniaNational Institute for Medical Research (NIMR)-Mbeya Medical Research Center (MMRC), Mbeya, TanzaniaDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, GermanyNational Institute for Medical Research (NIMR)-Mbeya Medical Research Center (MMRC), Mbeya, TanzaniaDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, GermanyDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, GermanyNational Institute for Medical Research (NIMR)-Mbeya Medical Research Center (MMRC), Mbeya, TanzaniaInstitute for Pathology, Otto-von-Guericke University Magdeburg, Magdeburg, GermanyNational Institute for Medical Research (NIMR)-Mbeya Medical Research Center (MMRC), Mbeya, TanzaniaNational Institute for Medical Research (NIMR)-Mbeya Medical Research Center (MMRC), Mbeya, TanzaniaNational Institute for Medical Research (NIMR)-Mbeya Medical Research Center (MMRC), Mbeya, TanzaniaDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, GermanyGerman Center for Infection Research (DZIF), Partner Site Munich, Munich, GermanyDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, GermanyGerman Center for Infection Research (DZIF), Partner Site Munich, Munich, GermanyDepartment of Gynecology and Obstetrics, University of Muenster, Muenster, GermanyDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, GermanyGerman Center for Infection Research (DZIF), Partner Site Munich, Munich, GermanyNational Institute for Medical Research (NIMR)-Mbeya Medical Research Center (MMRC), Mbeya, TanzaniaNational Institute for Medical Research (NIMR)-Mbeya Medical Research Center (MMRC), Mbeya, TanzaniaDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, GermanyUniversity of Dar es Salaam–Mbeya College of Health and Allied Sciences (UDSM-MCHAS), Mbeya, TanzaniaDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, GermanyGerman Center for Infection Research (DZIF), Partner Site Munich, Munich, GermanyDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, GermanyGerman Center for Infection Research (DZIF), Partner Site Munich, Munich, GermanyBackgroundWomen living with HIV in sub-Saharan Africa are at increased risk to develop cervical cancer (CC), which is caused by persistent infection with 13 oncogenic human papilloma viruses (HR-HPVs). It is important to accurately identify and target HIV-positive women at highest risk to develop CC for early therapeutic intervention.MethodsA total of 2,134 HIV+ and HIV− women from South-West Tanzania were prospectively screened for cervical cancer and precancerous lesions. Women with cervical cancer (n=236), high- and low-grade squamous intraepithelial lesions (HSIL: n=68, LSIL: n=74), and without lesion (n=426) underwent high-resolution HPV genotyping.ResultsEighty percent of women who were diagnosed with HSIL or LSIL were living with HIV. Any lesion, young age, HIV status, and depleted CD4 T cell counts were independent risk factors for HPV infections, which were predominantly caused by HR-HPV types. While multiple HR-HPV type infections were predominant in HIV+ women with HSIL, single-type infections predominated in HIV+ CC cases (p=0.0006). HPV16, 18, and 45 accounted for 85% (68/80) and 75% (82/110) of HIV+ and HIV− CC cases, respectively. Of note, HPV35, the most frequent HPV type in HSIL-positive women living with HIV, was rarely detected as a single-type infection in HSIL and cancer cases.ConclusionHPV16, 18, and 45 should receive special attention for molecular diagnostic algorithms during CC prevention programs for HIV+ women from sub-Saharan Africa. HPV35 may have a high potential to induce HSIL in women living with HIV, but less potential to cause cervical cancer in single-type infections.https://www.frontiersin.org/articles/10.3389/fonc.2021.763717/fullhuman papilloma virus—HPVhuman immunodeficiency virus—HIVcervical cancercervical dysplasiahigh-grade intraepithelial lesionslow-grade intraepithelial lesions |
| spellingShingle | Ruby Mcharo Tessa Lennemann Tessa Lennemann John France Liseth Torres Mercè Garí Wilbert Mbuya Wilbert Mbuya Wolfram Mwalongo Anifrid Mahenge Asli Bauer Asli Bauer Jonathan Mnkai Laura Glasmeyer Mona Judick Matilda Paul Nicolas Schroeder Bareke Msomba Magreth Sembo Nhamo Chiwerengo Michael Hoelscher Michael Hoelscher Otto Geisenberger Otto Geisenberger Ralph J. Lelle Elmar Saathoff Elmar Saathoff Leonard Maboko Mkunde Chachage Mkunde Chachage Mkunde Chachage Arne Kroidl Arne Kroidl Christof Geldmacher Christof Geldmacher HPV Type Distribution in HIV Positive and Negative Women With or Without Cervical Dysplasia or Cancer in East Africa Frontiers in Oncology human papilloma virus—HPV human immunodeficiency virus—HIV cervical cancer cervical dysplasia high-grade intraepithelial lesions low-grade intraepithelial lesions |
| title | HPV Type Distribution in HIV Positive and Negative Women With or Without Cervical Dysplasia or Cancer in East Africa |
| title_full | HPV Type Distribution in HIV Positive and Negative Women With or Without Cervical Dysplasia or Cancer in East Africa |
| title_fullStr | HPV Type Distribution in HIV Positive and Negative Women With or Without Cervical Dysplasia or Cancer in East Africa |
| title_full_unstemmed | HPV Type Distribution in HIV Positive and Negative Women With or Without Cervical Dysplasia or Cancer in East Africa |
| title_short | HPV Type Distribution in HIV Positive and Negative Women With or Without Cervical Dysplasia or Cancer in East Africa |
| title_sort | hpv type distribution in hiv positive and negative women with or without cervical dysplasia or cancer in east africa |
| topic | human papilloma virus—HPV human immunodeficiency virus—HIV cervical cancer cervical dysplasia high-grade intraepithelial lesions low-grade intraepithelial lesions |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.763717/full |
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