Robust Causal Estimation from Observational Studies Using Penalized Spline of Propensity Score for Treatment Comparison
Without randomization of treatments, valid inference of treatment effects from observational studies requires controlling for all confounders because the treated subjects generally differ systematically from the control subjects. Confounding control is commonly achieved using the propensity score, d...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Online Access: | https://www.mdpi.com/2571-905X/4/2/32 |
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| author | Tingting Zhou Michael R. Elliott Roderick J. A. Little |
| author_facet | Tingting Zhou Michael R. Elliott Roderick J. A. Little |
| author_sort | Tingting Zhou |
| collection | DOAJ |
| description | Without randomization of treatments, valid inference of treatment effects from observational studies requires controlling for all confounders because the treated subjects generally differ systematically from the control subjects. Confounding control is commonly achieved using the propensity score, defined as the conditional probability of assignment to a treatment given the observed covariates. The propensity score collapses all the observed covariates into a single measure and serves as a balancing score such that the treated and control subjects with similar propensity scores can be directly compared. Common propensity score-based methods include regression adjustment and inverse probability of treatment weighting using the propensity score. We recently proposed a robust multiple imputation-based method, penalized spline of propensity for treatment comparisons (PENCOMP), that includes a penalized spline of the assignment propensity as a predictor. Under the Rubin causal model assumptions that there is no interference across units, that each unit has a non-zero probability of being assigned to either treatment group, and there are no unmeasured confounders, PENCOMP has a double robustness property for estimating treatment effects. In this study, we examine the impact of using variable selection techniques that restrict predictors in the propensity score model to true confounders of the treatment-outcome relationship on PENCOMP. We also propose a variant of PENCOMP and compare alternative approaches to standard error estimation for PENCOMP. Compared to the weighted estimators, PENCOMP is less affected by inclusion of non-confounding variables in the propensity score model. We illustrate the use of PENCOMP and competing methods in estimating the impact of antiretroviral treatments on CD4 counts in HIV+ patients. |
| first_indexed | 2024-03-10T10:31:54Z |
| format | Article |
| id | doaj.art-15beefc7888246a0a926fb51f8ea924b |
| institution | Directory Open Access Journal |
| issn | 2571-905X |
| language | English |
| last_indexed | 2024-03-10T10:31:54Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Stats |
| spelling | doaj.art-15beefc7888246a0a926fb51f8ea924b2023-11-21T23:33:42ZengMDPI AGStats2571-905X2021-06-014252954910.3390/stats4020032Robust Causal Estimation from Observational Studies Using Penalized Spline of Propensity Score for Treatment ComparisonTingting Zhou0Michael R. Elliott1Roderick J. A. Little2U.S. Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USADepartment of Biostatistics, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, USADepartment of Biostatistics, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, USAWithout randomization of treatments, valid inference of treatment effects from observational studies requires controlling for all confounders because the treated subjects generally differ systematically from the control subjects. Confounding control is commonly achieved using the propensity score, defined as the conditional probability of assignment to a treatment given the observed covariates. The propensity score collapses all the observed covariates into a single measure and serves as a balancing score such that the treated and control subjects with similar propensity scores can be directly compared. Common propensity score-based methods include regression adjustment and inverse probability of treatment weighting using the propensity score. We recently proposed a robust multiple imputation-based method, penalized spline of propensity for treatment comparisons (PENCOMP), that includes a penalized spline of the assignment propensity as a predictor. Under the Rubin causal model assumptions that there is no interference across units, that each unit has a non-zero probability of being assigned to either treatment group, and there are no unmeasured confounders, PENCOMP has a double robustness property for estimating treatment effects. In this study, we examine the impact of using variable selection techniques that restrict predictors in the propensity score model to true confounders of the treatment-outcome relationship on PENCOMP. We also propose a variant of PENCOMP and compare alternative approaches to standard error estimation for PENCOMP. Compared to the weighted estimators, PENCOMP is less affected by inclusion of non-confounding variables in the propensity score model. We illustrate the use of PENCOMP and competing methods in estimating the impact of antiretroviral treatments on CD4 counts in HIV+ patients.https://www.mdpi.com/2571-905X/4/2/32causal inferencedouble robustnessPENCOMPvariable selectionpenalized spline |
| spellingShingle | Tingting Zhou Michael R. Elliott Roderick J. A. Little Robust Causal Estimation from Observational Studies Using Penalized Spline of Propensity Score for Treatment Comparison Stats causal inference double robustness PENCOMP variable selection penalized spline |
| title | Robust Causal Estimation from Observational Studies Using Penalized Spline of Propensity Score for Treatment Comparison |
| title_full | Robust Causal Estimation from Observational Studies Using Penalized Spline of Propensity Score for Treatment Comparison |
| title_fullStr | Robust Causal Estimation from Observational Studies Using Penalized Spline of Propensity Score for Treatment Comparison |
| title_full_unstemmed | Robust Causal Estimation from Observational Studies Using Penalized Spline of Propensity Score for Treatment Comparison |
| title_short | Robust Causal Estimation from Observational Studies Using Penalized Spline of Propensity Score for Treatment Comparison |
| title_sort | robust causal estimation from observational studies using penalized spline of propensity score for treatment comparison |
| topic | causal inference double robustness PENCOMP variable selection penalized spline |
| url | https://www.mdpi.com/2571-905X/4/2/32 |
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