TFE3-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour
TFE3-rearranged renal cell carcinoma (RCC) is a rare but well characterised histological subtype of RCC with an aggressive clinical course and propensity for late metastases. Osseous metaplasia is an uncommon but well documented finding in clear cell, papillary and chromophobe RCC. We present the fi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Urology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214442022000535 |
| _version_ | 1819349501472669696 |
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| author | Alessandro Pietro Aldera Amsha Ramburan Jeff John |
| author_facet | Alessandro Pietro Aldera Amsha Ramburan Jeff John |
| author_sort | Alessandro Pietro Aldera |
| collection | DOAJ |
| description | TFE3-rearranged renal cell carcinoma (RCC) is a rare but well characterised histological subtype of RCC with an aggressive clinical course and propensity for late metastases. Osseous metaplasia is an uncommon but well documented finding in clear cell, papillary and chromophobe RCC. We present the first case of a TFE3-rearranged RCC to be found harbouring metaplastic bone in a 47-year-old woman who presented with a slowly enlarging left flank mass over a 10 year period. This case report adds to the clinicopathological description of TFE3-rearranged RCC and suggests that larger studies are required to fully elucidate the prognosis of these tumours. |
| first_indexed | 2024-12-24T19:01:32Z |
| format | Article |
| id | doaj.art-15bf463f358e4af189ba06c9566b43fc |
| institution | Directory Open Access Journal |
| issn | 2214-4420 |
| language | English |
| last_indexed | 2024-12-24T19:01:32Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Urology Case Reports |
| spelling | doaj.art-15bf463f358e4af189ba06c9566b43fc2022-12-21T16:43:11ZengElsevierUrology Case Reports2214-44202022-05-0142102041TFE3-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviourAlessandro Pietro Aldera0Amsha Ramburan1Jeff John2Division of Anatomical Pathology, Faculty of Health Sciences, University of Cape Town, South Africa; JDW Pathology Inc, Cape Town, South Africa; Corresponding author. 19 Upper Camp Road, Chapters House, Maitland, 7405, Cape Town, South Africa.Division of Anatomical Pathology, Faculty of Health Sciences, University of Cape Town, South Africa; National Health Laboratory Service, Groote Schuur Hospital, Cape Town, South AfricaDivision of Urology, Department of Surgery, Frere Hospital and Walter Sisulu University, East London, South AfricaTFE3-rearranged renal cell carcinoma (RCC) is a rare but well characterised histological subtype of RCC with an aggressive clinical course and propensity for late metastases. Osseous metaplasia is an uncommon but well documented finding in clear cell, papillary and chromophobe RCC. We present the first case of a TFE3-rearranged RCC to be found harbouring metaplastic bone in a 47-year-old woman who presented with a slowly enlarging left flank mass over a 10 year period. This case report adds to the clinicopathological description of TFE3-rearranged RCC and suggests that larger studies are required to fully elucidate the prognosis of these tumours.http://www.sciencedirect.com/science/article/pii/S2214442022000535Renal cell carcinomaXp11.2TFE3OncologyBone |
| spellingShingle | Alessandro Pietro Aldera Amsha Ramburan Jeff John TFE3-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour Urology Case Reports Renal cell carcinoma Xp11.2 TFE3 Oncology Bone |
| title | TFE3-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour |
| title_full | TFE3-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour |
| title_fullStr | TFE3-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour |
| title_full_unstemmed | TFE3-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour |
| title_short | TFE3-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour |
| title_sort | tfe3 rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour |
| topic | Renal cell carcinoma Xp11.2 TFE3 Oncology Bone |
| url | http://www.sciencedirect.com/science/article/pii/S2214442022000535 |
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