Antiangiogenic Polyketides from Peperomia dindygulensis Miq.
Two new polyketides: 2Z-(heptadec-12-enyl)-4-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-one (1) and 2-(heptadec-12-enyl)-5-hydroxy-5,6,7,8-tetrahydrochromen- 4-one (2), together with eleven known compounds: 4-hydroxy-2-[(3,4-methylenedioxy- phenyl)tridecanoyl] cyclohexane-1,3-dione (3), oleiferinon...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-04-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/17/4/4474/ |
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| author | Hong-Zhuan Chen Guo-Hong Yang Chao Fang Yi-Fang Yang Xue-Mei Qin Chao Wang Qin Lu Gui-Xiu Li Wen-Jun Zhu Mei Zhao De-Hong Yu Meng-Gan Lin Qi-Wei Wang |
| author_facet | Hong-Zhuan Chen Guo-Hong Yang Chao Fang Yi-Fang Yang Xue-Mei Qin Chao Wang Qin Lu Gui-Xiu Li Wen-Jun Zhu Mei Zhao De-Hong Yu Meng-Gan Lin Qi-Wei Wang |
| author_sort | Hong-Zhuan Chen |
| collection | DOAJ |
| description | Two new polyketides: 2Z-(heptadec-12-enyl)-4-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-one (1) and 2-(heptadec-12-enyl)-5-hydroxy-5,6,7,8-tetrahydrochromen- 4-one (2), together with eleven known compounds: 4-hydroxy-2-[(3,4-methylenedioxy- phenyl)tridecanoyl] cyclohexane-1,3-dione (3), oleiferinone (4), 4-hydroxy-2-[(3,4- methylenedioxyphenyl)undecanoyl]cyclohexane-1,3-dione (5), 4-hydroxy-2-[(11-phenyl- undecanoyl)cyclohexane-1,3-dione (6), proctorione C (7), surinone C (8), 5-hydroxy- 7,8,4'-trimethoxyflavone (9), 5-hydroxy-7,8,3',4'-tetramethoxyflavone (10), 5-hydroxy- 7,3',4'-trimethoxyflavone (11), 5,8-dihydroxy-7,3',4'-trimethoxyflavone (12) and cepharanone B (13) were isolated from the whole plant of Peperomia dindygulensis Miq. Their structures were elucidated by spectroscopic methods, including 2D-NMR techniques. Compounds 2, 3, 5 and 8 inhibited human umbilical vein endothelial cell (HUVEC) proliferation and compounds 5 and 8 sharply suppressed HUVEC tube formation. |
| first_indexed | 2024-04-12T21:41:49Z |
| format | Article |
| id | doaj.art-15bf73b8a2974c548476f50e0e550e1c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T21:41:49Z |
| publishDate | 2012-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-15bf73b8a2974c548476f50e0e550e1c2022-12-22T03:15:44ZengMDPI AGMolecules1420-30492012-04-011744474448310.3390/molecules17044474Antiangiogenic Polyketides from Peperomia dindygulensis Miq.Hong-Zhuan ChenGuo-Hong YangChao FangYi-Fang YangXue-Mei QinChao WangQin LuGui-Xiu LiWen-Jun ZhuMei ZhaoDe-Hong YuMeng-Gan LinQi-Wei WangTwo new polyketides: 2Z-(heptadec-12-enyl)-4-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-one (1) and 2-(heptadec-12-enyl)-5-hydroxy-5,6,7,8-tetrahydrochromen- 4-one (2), together with eleven known compounds: 4-hydroxy-2-[(3,4-methylenedioxy- phenyl)tridecanoyl] cyclohexane-1,3-dione (3), oleiferinone (4), 4-hydroxy-2-[(3,4- methylenedioxyphenyl)undecanoyl]cyclohexane-1,3-dione (5), 4-hydroxy-2-[(11-phenyl- undecanoyl)cyclohexane-1,3-dione (6), proctorione C (7), surinone C (8), 5-hydroxy- 7,8,4'-trimethoxyflavone (9), 5-hydroxy-7,8,3',4'-tetramethoxyflavone (10), 5-hydroxy- 7,3',4'-trimethoxyflavone (11), 5,8-dihydroxy-7,3',4'-trimethoxyflavone (12) and cepharanone B (13) were isolated from the whole plant of Peperomia dindygulensis Miq. Their structures were elucidated by spectroscopic methods, including 2D-NMR techniques. Compounds 2, 3, 5 and 8 inhibited human umbilical vein endothelial cell (HUVEC) proliferation and compounds 5 and 8 sharply suppressed HUVEC tube formation.http://www.mdpi.com/1420-3049/17/4/4474/Peperomia dindygulensis Miq.polyketidesantiangiogenic activity |
| spellingShingle | Hong-Zhuan Chen Guo-Hong Yang Chao Fang Yi-Fang Yang Xue-Mei Qin Chao Wang Qin Lu Gui-Xiu Li Wen-Jun Zhu Mei Zhao De-Hong Yu Meng-Gan Lin Qi-Wei Wang Antiangiogenic Polyketides from Peperomia dindygulensis Miq. Molecules Peperomia dindygulensis Miq. polyketides antiangiogenic activity |
| title | Antiangiogenic Polyketides from Peperomia dindygulensis Miq. |
| title_full | Antiangiogenic Polyketides from Peperomia dindygulensis Miq. |
| title_fullStr | Antiangiogenic Polyketides from Peperomia dindygulensis Miq. |
| title_full_unstemmed | Antiangiogenic Polyketides from Peperomia dindygulensis Miq. |
| title_short | Antiangiogenic Polyketides from Peperomia dindygulensis Miq. |
| title_sort | antiangiogenic polyketides from peperomia dindygulensis miq |
| topic | Peperomia dindygulensis Miq. polyketides antiangiogenic activity |
| url | http://www.mdpi.com/1420-3049/17/4/4474/ |
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