Evaluating proxies for motion sickness in rodent
Motions sickness (MS) occurs when the brain receives conflicting sensory signals from vestibular, visual and proprioceptive systems about a person’s ongoing position and/or motion in relation to space. MS is typified by symptoms such as nausea and emesis and implicates complex physiological aspects...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
|
| Series: | IBRO Neuroscience Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242123000544 |
| _version_ | 1797383635900301312 |
|---|---|
| author | Fu-Xing Zhang Xiao-Hang Xie Zi-Xin Guo Hao-Dong Wang Hui Li Kenneth Lap Kei Wu Ying-Shing Chan Yun-Qing Li |
| author_facet | Fu-Xing Zhang Xiao-Hang Xie Zi-Xin Guo Hao-Dong Wang Hui Li Kenneth Lap Kei Wu Ying-Shing Chan Yun-Qing Li |
| author_sort | Fu-Xing Zhang |
| collection | DOAJ |
| description | Motions sickness (MS) occurs when the brain receives conflicting sensory signals from vestibular, visual and proprioceptive systems about a person’s ongoing position and/or motion in relation to space. MS is typified by symptoms such as nausea and emesis and implicates complex physiological aspects of sensations and sensorimotor reflexes. Use of animal models has been integral to unraveling the physiological causality of MS. The commonly used rodents (rat and mouse), albeit lacking vomiting reflex, reliably display phenotypic behaviors of pica (eating of non-nutritive substance) and conditioned taste aversion (CTAver) or avoidance (CTAvoi) which utilize neural substrates with pathways that cause gastrointestinal malaise akin to nausea/emesis. As such, rodent pica and CTAver/CTAvoi have been widely used as proxies for nausea/emesis in studies dealing with neural mechanisms of nausea/emesis and MS, as well as for evaluating therapeutics. This review presents the rationale and experimental evidence that support the use of pica and CTAver/CTAvoi as indices for nausea and emesis. Key experimental steps and cautions required when using rodent MS models are also discussed. Finally, future directions are suggested for studying MS with rodent pica and CTAver/CTAvoi models. |
| first_indexed | 2024-03-08T21:23:55Z |
| format | Article |
| id | doaj.art-15c019df8f4944579764a566f05d1767 |
| institution | Directory Open Access Journal |
| issn | 2667-2421 |
| language | English |
| last_indexed | 2024-03-08T21:23:55Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj.art-15c019df8f4944579764a566f05d17672023-12-21T07:38:23ZengElsevierIBRO Neuroscience Reports2667-24212023-12-0115107115Evaluating proxies for motion sickness in rodentFu-Xing Zhang0Xiao-Hang Xie1Zi-Xin Guo2Hao-Dong Wang3Hui Li4Kenneth Lap Kei Wu5Ying-Shing Chan6Yun-Qing Li7Department of Human Anatomy, Histology and Embryology & K.K. Leung Brain Research Centre, School of Basic Medicine, The Fourth Military Medical University, Xi’an, PR China; Corresponding authors.Department of Human Anatomy, Histology and Embryology & K.K. Leung Brain Research Centre, School of Basic Medicine, The Fourth Military Medical University, Xi’an, PR ChinaDepartment of Human Anatomy, Histology and Embryology & K.K. Leung Brain Research Centre, School of Basic Medicine, The Fourth Military Medical University, Xi’an, PR ChinaDepartment of Human Anatomy, Histology and Embryology & K.K. Leung Brain Research Centre, School of Basic Medicine, The Fourth Military Medical University, Xi’an, PR ChinaDepartment of Human Anatomy, Histology and Embryology & K.K. Leung Brain Research Centre, School of Basic Medicine, The Fourth Military Medical University, Xi’an, PR ChinaSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China; Corresponding author at: School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.Department of Human Anatomy, Histology and Embryology & K.K. Leung Brain Research Centre, School of Basic Medicine, The Fourth Military Medical University, Xi’an, PR China; Corresponding authors.Motions sickness (MS) occurs when the brain receives conflicting sensory signals from vestibular, visual and proprioceptive systems about a person’s ongoing position and/or motion in relation to space. MS is typified by symptoms such as nausea and emesis and implicates complex physiological aspects of sensations and sensorimotor reflexes. Use of animal models has been integral to unraveling the physiological causality of MS. The commonly used rodents (rat and mouse), albeit lacking vomiting reflex, reliably display phenotypic behaviors of pica (eating of non-nutritive substance) and conditioned taste aversion (CTAver) or avoidance (CTAvoi) which utilize neural substrates with pathways that cause gastrointestinal malaise akin to nausea/emesis. As such, rodent pica and CTAver/CTAvoi have been widely used as proxies for nausea/emesis in studies dealing with neural mechanisms of nausea/emesis and MS, as well as for evaluating therapeutics. This review presents the rationale and experimental evidence that support the use of pica and CTAver/CTAvoi as indices for nausea and emesis. Key experimental steps and cautions required when using rodent MS models are also discussed. Finally, future directions are suggested for studying MS with rodent pica and CTAver/CTAvoi models.http://www.sciencedirect.com/science/article/pii/S2667242123000544Conditioned taste aversionEmesisMotion sicknessNauseaPicaRodent models |
| spellingShingle | Fu-Xing Zhang Xiao-Hang Xie Zi-Xin Guo Hao-Dong Wang Hui Li Kenneth Lap Kei Wu Ying-Shing Chan Yun-Qing Li Evaluating proxies for motion sickness in rodent IBRO Neuroscience Reports Conditioned taste aversion Emesis Motion sickness Nausea Pica Rodent models |
| title | Evaluating proxies for motion sickness in rodent |
| title_full | Evaluating proxies for motion sickness in rodent |
| title_fullStr | Evaluating proxies for motion sickness in rodent |
| title_full_unstemmed | Evaluating proxies for motion sickness in rodent |
| title_short | Evaluating proxies for motion sickness in rodent |
| title_sort | evaluating proxies for motion sickness in rodent |
| topic | Conditioned taste aversion Emesis Motion sickness Nausea Pica Rodent models |
| url | http://www.sciencedirect.com/science/article/pii/S2667242123000544 |
| work_keys_str_mv | AT fuxingzhang evaluatingproxiesformotionsicknessinrodent AT xiaohangxie evaluatingproxiesformotionsicknessinrodent AT zixinguo evaluatingproxiesformotionsicknessinrodent AT haodongwang evaluatingproxiesformotionsicknessinrodent AT huili evaluatingproxiesformotionsicknessinrodent AT kennethlapkeiwu evaluatingproxiesformotionsicknessinrodent AT yingshingchan evaluatingproxiesformotionsicknessinrodent AT yunqingli evaluatingproxiesformotionsicknessinrodent |