Association Between Disease Activity, Asymmetric dimethylarginine, Tumor Necrosis Factor-Alpha, Interleukin-10 And Neopterin with Echocardiography And Blood Pressure Monitoring Findings in Systemic Lupus Erythematosus Patients
Pulse wave velocity (PWV) and augmentation index (AIx) have been repeatedly showed to be correlated with premature atherosclerosis. The increased arterial stiffness and endothelium dysfunction may cause premature aging of the arteries in patients with systemic lupus erythematosus (SLE). However, the...
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Society of Turaz Bilim
2019-12-01
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| Series: | Medicine Science |
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| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=49910 |
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| author | Tarik Demi& 775;r Fi& 775;kret Akyurek Sedat Abusoglu Ali& 775; Unlu Kenan Demi& 775;r Ahmet Avci Sema Yilmaz |
| author_facet | Tarik Demi& 775;r Fi& 775;kret Akyurek Sedat Abusoglu Ali& 775; Unlu Kenan Demi& 775;r Ahmet Avci Sema Yilmaz |
| author_sort | Tarik Demi& 775;r |
| collection | DOAJ |
| description | Pulse wave velocity (PWV) and augmentation index (AIx) have been repeatedly showed to be correlated with premature atherosclerosis. The increased arterial stiffness and endothelium dysfunction may cause premature aging of the arteries in patients with systemic lupus erythematosus (SLE). However, the association of PWV and its markers, AIx, has not been linked to SLE Disease Activity Index (SLEDAI), Asymmetric dimethylarginine (ADMA) and inflammatory cytokines in SLE women. 57 women diagnosed with SLE and 31 healthy women were consequently included in the study and both groups were compared according to age, body mass index (BMI), serum lipid profile, creatinine, cardiac parameters, blood pressure. Tumor Necrosis Factor-Alpha (TNF-α), Interleukin 10 (IL-10), neopterin, and ADMA were assayed. In SLE women, PWV was significantly higher (p=0.04), and AIx was not different from controls (p=0.136). In linear multiple stepwise regression analysis, when patients and controls were both considered, PWV was weakly related to age (p=0.001), waist circumference (p=0.003), LDL-cholesterol (p=0.018), ADMA (p=0.042). Although, when the individual SLE setting was analyzed, PWV was not related to organ damage measured by SLEDAI (p=0.4), ADMA (p=0.361), TNF-α (p=0.893), IL-10 (p=0.686), and neopterin (p=(0.444)). PWV was significantly related to mean blood pressure (MBP) (p=0.001), age (p=0.001), disease duration (p=0.001) and glucocorticoid (p=0.014). Our data suggest that controlling MBP and appropriate indications of low doses steroids can partially slow down the process of early atherosclerosis in female patients diagnosed with SLE. [Med-Science 2019; 8(4.000): 998-1001] |
| first_indexed | 2024-03-08T06:51:43Z |
| format | Article |
| id | doaj.art-15c2e969e73641de84616cc1c5f8e978 |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T06:51:43Z |
| publishDate | 2019-12-01 |
| publisher | Society of Turaz Bilim |
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| series | Medicine Science |
| spelling | doaj.art-15c2e969e73641de84616cc1c5f8e9782024-02-03T06:40:37ZengSociety of Turaz BilimMedicine Science2147-06342019-12-0184998100110.5455/medscience.2019.08.911949910Association Between Disease Activity, Asymmetric dimethylarginine, Tumor Necrosis Factor-Alpha, Interleukin-10 And Neopterin with Echocardiography And Blood Pressure Monitoring Findings in Systemic Lupus Erythematosus PatientsTarik Demi& 775;r0Fi& 775;kret AkyurekSedat AbusogluAli& 775; UnluKenan Demi& 775;rAhmet AvciSema YilmazSelcuk University, Faculty of Medicine, Department of Internal Medicine, Konya, Turkey Selcuk University, Faculty of Medicine, Department of Biochemistry, Konya, Turkey Selcuk University, Faculty of Medicine, Department of Cardiology, Konya, Turkey Selcuk University, Faculty of Medicine, Department of Rheumatology, Konya, TurkeyPulse wave velocity (PWV) and augmentation index (AIx) have been repeatedly showed to be correlated with premature atherosclerosis. The increased arterial stiffness and endothelium dysfunction may cause premature aging of the arteries in patients with systemic lupus erythematosus (SLE). However, the association of PWV and its markers, AIx, has not been linked to SLE Disease Activity Index (SLEDAI), Asymmetric dimethylarginine (ADMA) and inflammatory cytokines in SLE women. 57 women diagnosed with SLE and 31 healthy women were consequently included in the study and both groups were compared according to age, body mass index (BMI), serum lipid profile, creatinine, cardiac parameters, blood pressure. Tumor Necrosis Factor-Alpha (TNF-α), Interleukin 10 (IL-10), neopterin, and ADMA were assayed. In SLE women, PWV was significantly higher (p=0.04), and AIx was not different from controls (p=0.136). In linear multiple stepwise regression analysis, when patients and controls were both considered, PWV was weakly related to age (p=0.001), waist circumference (p=0.003), LDL-cholesterol (p=0.018), ADMA (p=0.042). Although, when the individual SLE setting was analyzed, PWV was not related to organ damage measured by SLEDAI (p=0.4), ADMA (p=0.361), TNF-α (p=0.893), IL-10 (p=0.686), and neopterin (p=(0.444)). PWV was significantly related to mean blood pressure (MBP) (p=0.001), age (p=0.001), disease duration (p=0.001) and glucocorticoid (p=0.014). Our data suggest that controlling MBP and appropriate indications of low doses steroids can partially slow down the process of early atherosclerosis in female patients diagnosed with SLE. [Med-Science 2019; 8(4.000): 998-1001]http://www.ejmanager.com/fulltextpdf.php?mno=49910arterial stiffnessasymmetric dimethylarginineinterleukin 10neopterinsystemic lupus erythematosustumor necrosis factor-alpha |
| spellingShingle | Tarik Demi& 775;r Fi& 775;kret Akyurek Sedat Abusoglu Ali& 775; Unlu Kenan Demi& 775;r Ahmet Avci Sema Yilmaz Association Between Disease Activity, Asymmetric dimethylarginine, Tumor Necrosis Factor-Alpha, Interleukin-10 And Neopterin with Echocardiography And Blood Pressure Monitoring Findings in Systemic Lupus Erythematosus Patients Medicine Science arterial stiffness asymmetric dimethylarginine interleukin 10 neopterin systemic lupus erythematosus tumor necrosis factor-alpha |
| title | Association Between Disease Activity, Asymmetric dimethylarginine, Tumor Necrosis Factor-Alpha, Interleukin-10 And Neopterin with Echocardiography And Blood Pressure Monitoring Findings in Systemic Lupus Erythematosus Patients |
| title_full | Association Between Disease Activity, Asymmetric dimethylarginine, Tumor Necrosis Factor-Alpha, Interleukin-10 And Neopterin with Echocardiography And Blood Pressure Monitoring Findings in Systemic Lupus Erythematosus Patients |
| title_fullStr | Association Between Disease Activity, Asymmetric dimethylarginine, Tumor Necrosis Factor-Alpha, Interleukin-10 And Neopterin with Echocardiography And Blood Pressure Monitoring Findings in Systemic Lupus Erythematosus Patients |
| title_full_unstemmed | Association Between Disease Activity, Asymmetric dimethylarginine, Tumor Necrosis Factor-Alpha, Interleukin-10 And Neopterin with Echocardiography And Blood Pressure Monitoring Findings in Systemic Lupus Erythematosus Patients |
| title_short | Association Between Disease Activity, Asymmetric dimethylarginine, Tumor Necrosis Factor-Alpha, Interleukin-10 And Neopterin with Echocardiography And Blood Pressure Monitoring Findings in Systemic Lupus Erythematosus Patients |
| title_sort | association between disease activity asymmetric dimethylarginine tumor necrosis factor alpha interleukin 10 and neopterin with echocardiography and blood pressure monitoring findings in systemic lupus erythematosus patients |
| topic | arterial stiffness asymmetric dimethylarginine interleukin 10 neopterin systemic lupus erythematosus tumor necrosis factor-alpha |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=49910 |
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