Highly Correlated Recurrence Prognosis in Patients with Metastatic Colorectal Cancer by Synergistic Consideration of Circulating Tumor Cells/Microemboli and Tumor Markers CEA/CA19-9
Circulation tumor cells (CTCs) play an important role in metastasis and highly correlate with cancer progression; thus, CTCs could be considered as a powerful diagnosis tool. Our previous studies showed that the number of CTCs could be utilized for recurrence prediction in colorectal cancer (CRC); h...
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MDPI AG
2021-05-01
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| Online Access: | https://www.mdpi.com/2073-4409/10/5/1149 |
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| author | Hsueh-Yao Chu Chih-Yung Yang Ping-Hao Yeh Chun-Jieh Hsu Lu-Wei Chang Wei-Jen Chan Chien-Ping Lin You-You Lyu Wei-Cheng Wu Chun-Wei Lee Jen-Kuei Wu Jeng-Kai Jiang Fan-Gang Tseng |
| author_facet | Hsueh-Yao Chu Chih-Yung Yang Ping-Hao Yeh Chun-Jieh Hsu Lu-Wei Chang Wei-Jen Chan Chien-Ping Lin You-You Lyu Wei-Cheng Wu Chun-Wei Lee Jen-Kuei Wu Jeng-Kai Jiang Fan-Gang Tseng |
| author_sort | Hsueh-Yao Chu |
| collection | DOAJ |
| description | Circulation tumor cells (CTCs) play an important role in metastasis and highly correlate with cancer progression; thus, CTCs could be considered as a powerful diagnosis tool. Our previous studies showed that the number of CTCs could be utilized for recurrence prediction in colorectal cancer (CRC); however, the odds ratio was still lower than five. To improve prognosis in CRC patients, we analyzed CTC clusters/microemboli, CTC numbers, and carcinoembryonic antigen (CEA)/carbohydrate antigen 19-9 (CA19-9) levels using a self-assembled cell array (SACA) chip system for recurrence prediction. In CRC patients, the presence of CTC clusters/microemboli may have higher correlation in metastasis when compared to the high number of CTCs. Additionally, when both the number of CTCs and serum CEA levels are high, very high odds ratios of 24.4 and 17.1 are observed in patients at all stages and stage III of CRC, respectively. The high number of CTCs and CTC clusters/microemboli simultaneously suggests the high chance of relapse (odds ratio 8.4). Overall, the characteristic of CTC clusters/microemboli, CEA level, and CTC number have a clinical potential to enhance CRC prognosis. |
| first_indexed | 2024-03-10T11:33:22Z |
| format | Article |
| id | doaj.art-15c3578c8a544edd8588d7a92704081b |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T11:33:22Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-15c3578c8a544edd8588d7a92704081b2023-11-21T19:00:58ZengMDPI AGCells2073-44092021-05-01105114910.3390/cells10051149Highly Correlated Recurrence Prognosis in Patients with Metastatic Colorectal Cancer by Synergistic Consideration of Circulating Tumor Cells/Microemboli and Tumor Markers CEA/CA19-9Hsueh-Yao Chu0Chih-Yung Yang1Ping-Hao Yeh2Chun-Jieh Hsu3Lu-Wei Chang4Wei-Jen Chan5Chien-Ping Lin6You-You Lyu7Wei-Cheng Wu8Chun-Wei Lee9Jen-Kuei Wu10Jeng-Kai Jiang11Fan-Gang Tseng12Department of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, TaiwanDepartment Education Research, Taipei City Hospital, Taipei 10341, TaiwanDepartment of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, TaiwanDepartment of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, TaiwanDepartment of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, TaiwanDepartment of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, TaiwanInstitute of Microbiology and Immunology, National Yang-Ming Chiao-Tung University, Taipei 11221, TaiwanInstitute of Microbiology and Immunology, National Yang-Ming Chiao-Tung University, Taipei 11221, TaiwanDepartment of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, TaiwanDepartment of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, TaiwanDepartment of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, TaiwanDepartment of Surgery, Division of Colorectal Surgery, Taipei Veterans General Hospital, Taiwan School of Medicine, National Yang-Ming Chiao-Tung University, Taipei 11217, TaiwanDepartment of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, TaiwanCirculation tumor cells (CTCs) play an important role in metastasis and highly correlate with cancer progression; thus, CTCs could be considered as a powerful diagnosis tool. Our previous studies showed that the number of CTCs could be utilized for recurrence prediction in colorectal cancer (CRC); however, the odds ratio was still lower than five. To improve prognosis in CRC patients, we analyzed CTC clusters/microemboli, CTC numbers, and carcinoembryonic antigen (CEA)/carbohydrate antigen 19-9 (CA19-9) levels using a self-assembled cell array (SACA) chip system for recurrence prediction. In CRC patients, the presence of CTC clusters/microemboli may have higher correlation in metastasis when compared to the high number of CTCs. Additionally, when both the number of CTCs and serum CEA levels are high, very high odds ratios of 24.4 and 17.1 are observed in patients at all stages and stage III of CRC, respectively. The high number of CTCs and CTC clusters/microemboli simultaneously suggests the high chance of relapse (odds ratio 8.4). Overall, the characteristic of CTC clusters/microemboli, CEA level, and CTC number have a clinical potential to enhance CRC prognosis.https://www.mdpi.com/2073-4409/10/5/1149circulating tumor cell (CTC)CTC clustersprognostic analysiscolorectal cancer (CRC)liquid biopsycirculating tumor microemboli (CTM) |
| spellingShingle | Hsueh-Yao Chu Chih-Yung Yang Ping-Hao Yeh Chun-Jieh Hsu Lu-Wei Chang Wei-Jen Chan Chien-Ping Lin You-You Lyu Wei-Cheng Wu Chun-Wei Lee Jen-Kuei Wu Jeng-Kai Jiang Fan-Gang Tseng Highly Correlated Recurrence Prognosis in Patients with Metastatic Colorectal Cancer by Synergistic Consideration of Circulating Tumor Cells/Microemboli and Tumor Markers CEA/CA19-9 Cells circulating tumor cell (CTC) CTC clusters prognostic analysis colorectal cancer (CRC) liquid biopsy circulating tumor microemboli (CTM) |
| title | Highly Correlated Recurrence Prognosis in Patients with Metastatic Colorectal Cancer by Synergistic Consideration of Circulating Tumor Cells/Microemboli and Tumor Markers CEA/CA19-9 |
| title_full | Highly Correlated Recurrence Prognosis in Patients with Metastatic Colorectal Cancer by Synergistic Consideration of Circulating Tumor Cells/Microemboli and Tumor Markers CEA/CA19-9 |
| title_fullStr | Highly Correlated Recurrence Prognosis in Patients with Metastatic Colorectal Cancer by Synergistic Consideration of Circulating Tumor Cells/Microemboli and Tumor Markers CEA/CA19-9 |
| title_full_unstemmed | Highly Correlated Recurrence Prognosis in Patients with Metastatic Colorectal Cancer by Synergistic Consideration of Circulating Tumor Cells/Microemboli and Tumor Markers CEA/CA19-9 |
| title_short | Highly Correlated Recurrence Prognosis in Patients with Metastatic Colorectal Cancer by Synergistic Consideration of Circulating Tumor Cells/Microemboli and Tumor Markers CEA/CA19-9 |
| title_sort | highly correlated recurrence prognosis in patients with metastatic colorectal cancer by synergistic consideration of circulating tumor cells microemboli and tumor markers cea ca19 9 |
| topic | circulating tumor cell (CTC) CTC clusters prognostic analysis colorectal cancer (CRC) liquid biopsy circulating tumor microemboli (CTM) |
| url | https://www.mdpi.com/2073-4409/10/5/1149 |
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