The fertility assessment of normal cyclic Wistar rats following the administration of methanolic extract of Portulaca oleracea: an experimental study
Abstract Background Purslane is a widely distributed shrub used for the treatment of different ailments. The increasing reproductive complications associated with herbal treatments have led to the need to critically evaluate the safety and/or reproductive potentials of commonly used plant extracts....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-01-01
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| Series: | Middle East Fertility Society Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43043-020-00048-x |
| _version_ | 1818676128525582336 |
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| author | Izuchukwu Azuka Okafor Uchenna Somtochukwu Nnamah Jude Nnaka |
| author_facet | Izuchukwu Azuka Okafor Uchenna Somtochukwu Nnamah Jude Nnaka |
| author_sort | Izuchukwu Azuka Okafor |
| collection | DOAJ |
| description | Abstract Background Purslane is a widely distributed shrub used for the treatment of different ailments. The increasing reproductive complications associated with herbal treatments have led to the need to critically evaluate the safety and/or reproductive potentials of commonly used plant extracts. This study investigated the reproductive effect of methanolic extracts of Portulaca oleracea (MEPO) in adult female Wistar rats. Results Group C showed a significant decrease both in relative ovarian weight (p = 0.000), and relative uterine weight (p = 0.037), when compared with the control. There were no significant (p ˃ 0.05) changes in the levels of follicle-stimulating hormone, luteinizing hormone, progesterone, and estradiol. When compared to the control, groups B and C showed abnormal estrous cycle and cycle arrest especially at the metestrus phase with mild congestion of a few blood vessels in the ovary and uterus. Conclusions MEPO may possess some anti-fertility effect, as it disrupts the estrous cycle of adult female Wistar rats; although it has no major effect on the reproductive hormones, uterus, and ovarian histology of adult female Wistar rats. However, high dose consumption should be taken with precaution. |
| first_indexed | 2024-12-17T08:38:33Z |
| format | Article |
| id | doaj.art-15c62b3b1a4745f286b5a257ee9cde69 |
| institution | Directory Open Access Journal |
| issn | 2090-3251 |
| language | English |
| last_indexed | 2024-12-17T08:38:33Z |
| publishDate | 2021-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Middle East Fertility Society Journal |
| spelling | doaj.art-15c62b3b1a4745f286b5a257ee9cde692022-12-21T21:56:24ZengSpringerOpenMiddle East Fertility Society Journal2090-32512021-01-0126111010.1186/s43043-020-00048-xThe fertility assessment of normal cyclic Wistar rats following the administration of methanolic extract of Portulaca oleracea: an experimental studyIzuchukwu Azuka Okafor0Uchenna Somtochukwu Nnamah1Jude Nnaka2Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe UniversityHematology Department, Babcock University Teaching HospitalDepartment of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe UniversityAbstract Background Purslane is a widely distributed shrub used for the treatment of different ailments. The increasing reproductive complications associated with herbal treatments have led to the need to critically evaluate the safety and/or reproductive potentials of commonly used plant extracts. This study investigated the reproductive effect of methanolic extracts of Portulaca oleracea (MEPO) in adult female Wistar rats. Results Group C showed a significant decrease both in relative ovarian weight (p = 0.000), and relative uterine weight (p = 0.037), when compared with the control. There were no significant (p ˃ 0.05) changes in the levels of follicle-stimulating hormone, luteinizing hormone, progesterone, and estradiol. When compared to the control, groups B and C showed abnormal estrous cycle and cycle arrest especially at the metestrus phase with mild congestion of a few blood vessels in the ovary and uterus. Conclusions MEPO may possess some anti-fertility effect, as it disrupts the estrous cycle of adult female Wistar rats; although it has no major effect on the reproductive hormones, uterus, and ovarian histology of adult female Wistar rats. However, high dose consumption should be taken with precaution.https://doi.org/10.1186/s43043-020-00048-xPortulaca oleraceaAnti-fertilityWistar ratEstrous cycleReproductive hormonesUterus |
| spellingShingle | Izuchukwu Azuka Okafor Uchenna Somtochukwu Nnamah Jude Nnaka The fertility assessment of normal cyclic Wistar rats following the administration of methanolic extract of Portulaca oleracea: an experimental study Middle East Fertility Society Journal Portulaca oleracea Anti-fertility Wistar rat Estrous cycle Reproductive hormones Uterus |
| title | The fertility assessment of normal cyclic Wistar rats following the administration of methanolic extract of Portulaca oleracea: an experimental study |
| title_full | The fertility assessment of normal cyclic Wistar rats following the administration of methanolic extract of Portulaca oleracea: an experimental study |
| title_fullStr | The fertility assessment of normal cyclic Wistar rats following the administration of methanolic extract of Portulaca oleracea: an experimental study |
| title_full_unstemmed | The fertility assessment of normal cyclic Wistar rats following the administration of methanolic extract of Portulaca oleracea: an experimental study |
| title_short | The fertility assessment of normal cyclic Wistar rats following the administration of methanolic extract of Portulaca oleracea: an experimental study |
| title_sort | fertility assessment of normal cyclic wistar rats following the administration of methanolic extract of portulaca oleracea an experimental study |
| topic | Portulaca oleracea Anti-fertility Wistar rat Estrous cycle Reproductive hormones Uterus |
| url | https://doi.org/10.1186/s43043-020-00048-x |
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