Mutation in the Common Docking Domain Affects MAP Kinase ERK2 Catalysis and Stability

Mutation in the Common Docking Domain Affects MAP Kinase ERK2 Catalysis and Stability

The extracellular-signal-regulated kinase 2 (ERK2), a mitogen-activated protein kinase (MAPK) located downstream of the Ras-Raf-MEK-ERK signal transduction cascade, is involved in the regulation of a large variety of cellular processes. The ERK2, activated by phosphorylation, is the principal effect...

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Bibliographic Details
Main Authors: Leonore Novak, Maria Petrosino, Alessandra Pasquo, Apirat Chaikuad, Roberta Chiaraluce, Stefan Knapp, Valerio Consalvi
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cancers
Subjects:
single nucleotide variant
ERK2
MAPK1
protein stability
mutation
MAP kinase
Online Access:https://www.mdpi.com/2072-6694/15/11/2938

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