Phenolic Compounds Reduce the Fat Content in <i>Caenorhabditis elegans</i> by Affecting Lipogenesis, Lipolysis, and Different Stress Responses
Supplementation with bioactive compounds capable of regulating energy homeostasis is a promising strategy to manage obesity. Here, we have screened the ability of different phenolic compounds (myricetin, kaempferol, naringin, hesperidin, apigenin, luteolin, resveratrol, curcumin, and epicatechin) an...
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| Format: | Article |
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MDPI AG
2020-10-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/13/11/355 |
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| author | Paula Aranaz David Navarro-Herrera María Zabala Ana Romo-Hualde Miguel López-Yoldi José Luis Vizmanos Fermín I. Milagro Carlos J. González-Navarro |
| author_facet | Paula Aranaz David Navarro-Herrera María Zabala Ana Romo-Hualde Miguel López-Yoldi José Luis Vizmanos Fermín I. Milagro Carlos J. González-Navarro |
| author_sort | Paula Aranaz |
| collection | DOAJ |
| description | Supplementation with bioactive compounds capable of regulating energy homeostasis is a promising strategy to manage obesity. Here, we have screened the ability of different phenolic compounds (myricetin, kaempferol, naringin, hesperidin, apigenin, luteolin, resveratrol, curcumin, and epicatechin) and phenolic acids (<i>p</i>-coumaric, ellagic, ferulic, gallic, and vanillic acids) regulating <i>C. elegans</i> fat accumulation. Resveratrol exhibited the strongest lipid-reducing activity, which was accompanied by the improvement of lifespan, oxidative stress, and aging, without affecting worm development. Whole-genome expression microarrays demonstrated that resveratrol affected fat mobilization, fatty acid metabolism, and unfolded protein response of the endoplasmic reticulum (UPR<sup>ER</sup>), mimicking the response to calorie restriction. Apigenin induced the oxidative stress response and lipid mobilization, while vanillic acid affected the unfolded-protein response in ER. In summary, our data demonstrates that phenolic compounds exert a lipid-reducing activity in <i>C. elegans</i> through different biological processes and signaling pathways, including those related with lipid mobilization and fatty acid metabolism, oxidative stress, aging, and UPR-ER response. These findings open the door to the possibility of combining them in order to achieve complementary activity against obesity-related disorders. |
| first_indexed | 2024-03-10T15:12:37Z |
| format | Article |
| id | doaj.art-15cf32f985e44ef688ea63e587f7030f |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T15:12:37Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-15cf32f985e44ef688ea63e587f7030f2023-11-20T19:09:40ZengMDPI AGPharmaceuticals1424-82472020-10-01131135510.3390/ph13110355Phenolic Compounds Reduce the Fat Content in <i>Caenorhabditis elegans</i> by Affecting Lipogenesis, Lipolysis, and Different Stress ResponsesPaula Aranaz0David Navarro-Herrera1María Zabala2Ana Romo-Hualde3Miguel López-Yoldi4José Luis Vizmanos5Fermín I. Milagro6Carlos J. González-Navarro7Center for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, SpainCenter for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, SpainCenter for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, SpainCenter for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, SpainCenter for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, SpainNavarra Institute for Health Research (IdiSNA), 31008 Pamplona, SpainCenter for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, SpainCenter for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, SpainSupplementation with bioactive compounds capable of regulating energy homeostasis is a promising strategy to manage obesity. Here, we have screened the ability of different phenolic compounds (myricetin, kaempferol, naringin, hesperidin, apigenin, luteolin, resveratrol, curcumin, and epicatechin) and phenolic acids (<i>p</i>-coumaric, ellagic, ferulic, gallic, and vanillic acids) regulating <i>C. elegans</i> fat accumulation. Resveratrol exhibited the strongest lipid-reducing activity, which was accompanied by the improvement of lifespan, oxidative stress, and aging, without affecting worm development. Whole-genome expression microarrays demonstrated that resveratrol affected fat mobilization, fatty acid metabolism, and unfolded protein response of the endoplasmic reticulum (UPR<sup>ER</sup>), mimicking the response to calorie restriction. Apigenin induced the oxidative stress response and lipid mobilization, while vanillic acid affected the unfolded-protein response in ER. In summary, our data demonstrates that phenolic compounds exert a lipid-reducing activity in <i>C. elegans</i> through different biological processes and signaling pathways, including those related with lipid mobilization and fatty acid metabolism, oxidative stress, aging, and UPR-ER response. These findings open the door to the possibility of combining them in order to achieve complementary activity against obesity-related disorders.https://www.mdpi.com/1424-8247/13/11/355obesitybioactive compoundsresveratrolapigeninvanillic acid |
| spellingShingle | Paula Aranaz David Navarro-Herrera María Zabala Ana Romo-Hualde Miguel López-Yoldi José Luis Vizmanos Fermín I. Milagro Carlos J. González-Navarro Phenolic Compounds Reduce the Fat Content in <i>Caenorhabditis elegans</i> by Affecting Lipogenesis, Lipolysis, and Different Stress Responses Pharmaceuticals obesity bioactive compounds resveratrol apigenin vanillic acid |
| title | Phenolic Compounds Reduce the Fat Content in <i>Caenorhabditis elegans</i> by Affecting Lipogenesis, Lipolysis, and Different Stress Responses |
| title_full | Phenolic Compounds Reduce the Fat Content in <i>Caenorhabditis elegans</i> by Affecting Lipogenesis, Lipolysis, and Different Stress Responses |
| title_fullStr | Phenolic Compounds Reduce the Fat Content in <i>Caenorhabditis elegans</i> by Affecting Lipogenesis, Lipolysis, and Different Stress Responses |
| title_full_unstemmed | Phenolic Compounds Reduce the Fat Content in <i>Caenorhabditis elegans</i> by Affecting Lipogenesis, Lipolysis, and Different Stress Responses |
| title_short | Phenolic Compounds Reduce the Fat Content in <i>Caenorhabditis elegans</i> by Affecting Lipogenesis, Lipolysis, and Different Stress Responses |
| title_sort | phenolic compounds reduce the fat content in i caenorhabditis elegans i by affecting lipogenesis lipolysis and different stress responses |
| topic | obesity bioactive compounds resveratrol apigenin vanillic acid |
| url | https://www.mdpi.com/1424-8247/13/11/355 |
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