Etiology of precocious puberty, 10 years study in Endocrine Reserch Centre (Firouzgar), Tehran
Background: Precocious puberty, as early physical development and low final height might lead to psychosocial problems.Objective: To evaluate etiology and clinical feature of precocious puberty in a cohort of Iranian children.Materials and Methods: In this case-series study, 44 girls and 8 boys with...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shahid Sadoughi University of Medical Science, Yazd, Iran
2012-01-01
|
| Series: | Iranian Journal of Reproductive Medicine |
| Subjects: | |
| Online Access: | http://www.ijrm.ir/library/upload/article/af_26939531)%2089-34-6%20OK.pdf |
| _version_ | 1819206983768604672 |
|---|---|
| author | Fatemeh Safari Farzaneh Rohani Shadab Salehpur |
| author_facet | Fatemeh Safari Farzaneh Rohani Shadab Salehpur |
| author_sort | Fatemeh Safari |
| collection | DOAJ |
| description | Background: Precocious puberty, as early physical development and low final height might lead to psychosocial problems.Objective: To evaluate etiology and clinical feature of precocious puberty in a cohort of Iranian children.Materials and Methods: In this case-series study, 44 girls and 8 boys with precocious puberty referred to Endocrine Reserch Centre (Firouzgar), Institute of Endocrinology and Metabolism (Hemmat Campus), were examined in a 10 years period of time. Results: Mean age of girls and boys was 7.43±1.4 years and 5.8±2.1 years respectively. Most of the patients fell within the age category of 7-7.9 years old (40.9% for girls and 50% for boys). Patients, concerning etiology of precocious puberty were classified in three categories: 42.6% of patients had central precocious puberty (CPP), including idiopathic CPP (87.5%) and neurogenic CPP (12.5%). 23.3% of patients had peripheral precocious puberty (PPP), including congenital adrenal hyperplasia (CAH) (42.8%), ovarian cysts (28.4%), McCune-Albright syndrome (14.2%) and adrenal carcinoma (14.2%). 34.1% of girls and 25% of boys had normal variant puberty including premature thelarche (57%), premature adrenarche (38%) as well as premature menarche (4.7%l). Conclusion: The most common etiology of precocious puberty in girls was idiopathic central precocious puberty and premature thelarche, while in boys they were neurogenic central precocious puberty and CAH. Therefore precocious puberty in girls is usually benign. In boys, CNS anomalies should first be considered in the differential diagnosis of CPP. Therefore brain Magnetic Resonance Imaging (MRI) is mandatory in all cases. |
| first_indexed | 2024-12-23T05:16:16Z |
| format | Article |
| id | doaj.art-15cfe46cdd814ceaa14076cfab7a3fc5 |
| institution | Directory Open Access Journal |
| issn | 1680-6433 |
| language | English |
| last_indexed | 2024-12-23T05:16:16Z |
| publishDate | 2012-01-01 |
| publisher | Shahid Sadoughi University of Medical Science, Yazd, Iran |
| record_format | Article |
| series | Iranian Journal of Reproductive Medicine |
| spelling | doaj.art-15cfe46cdd814ceaa14076cfab7a3fc52022-12-21T17:58:48ZengShahid Sadoughi University of Medical Science, Yazd, IranIranian Journal of Reproductive Medicine1680-64332012-01-0110116Etiology of precocious puberty, 10 years study in Endocrine Reserch Centre (Firouzgar), TehranFatemeh SafariFarzaneh RohaniShadab SalehpurBackground: Precocious puberty, as early physical development and low final height might lead to psychosocial problems.Objective: To evaluate etiology and clinical feature of precocious puberty in a cohort of Iranian children.Materials and Methods: In this case-series study, 44 girls and 8 boys with precocious puberty referred to Endocrine Reserch Centre (Firouzgar), Institute of Endocrinology and Metabolism (Hemmat Campus), were examined in a 10 years period of time. Results: Mean age of girls and boys was 7.43±1.4 years and 5.8±2.1 years respectively. Most of the patients fell within the age category of 7-7.9 years old (40.9% for girls and 50% for boys). Patients, concerning etiology of precocious puberty were classified in three categories: 42.6% of patients had central precocious puberty (CPP), including idiopathic CPP (87.5%) and neurogenic CPP (12.5%). 23.3% of patients had peripheral precocious puberty (PPP), including congenital adrenal hyperplasia (CAH) (42.8%), ovarian cysts (28.4%), McCune-Albright syndrome (14.2%) and adrenal carcinoma (14.2%). 34.1% of girls and 25% of boys had normal variant puberty including premature thelarche (57%), premature adrenarche (38%) as well as premature menarche (4.7%l). Conclusion: The most common etiology of precocious puberty in girls was idiopathic central precocious puberty and premature thelarche, while in boys they were neurogenic central precocious puberty and CAH. Therefore precocious puberty in girls is usually benign. In boys, CNS anomalies should first be considered in the differential diagnosis of CPP. Therefore brain Magnetic Resonance Imaging (MRI) is mandatory in all cases.http://www.ijrm.ir/library/upload/article/af_26939531)%2089-34-6%20OK.pdfCentral precocious pubertyPeripheral precocious pubertyPremature thelarcheCongenital adrenal hyperplasia. |
| spellingShingle | Fatemeh Safari Farzaneh Rohani Shadab Salehpur Etiology of precocious puberty, 10 years study in Endocrine Reserch Centre (Firouzgar), Tehran Iranian Journal of Reproductive Medicine Central precocious puberty Peripheral precocious puberty Premature thelarche Congenital adrenal hyperplasia. |
| title | Etiology of precocious puberty, 10 years study in Endocrine Reserch Centre (Firouzgar), Tehran |
| title_full | Etiology of precocious puberty, 10 years study in Endocrine Reserch Centre (Firouzgar), Tehran |
| title_fullStr | Etiology of precocious puberty, 10 years study in Endocrine Reserch Centre (Firouzgar), Tehran |
| title_full_unstemmed | Etiology of precocious puberty, 10 years study in Endocrine Reserch Centre (Firouzgar), Tehran |
| title_short | Etiology of precocious puberty, 10 years study in Endocrine Reserch Centre (Firouzgar), Tehran |
| title_sort | etiology of precocious puberty 10 years study in endocrine reserch centre firouzgar tehran |
| topic | Central precocious puberty Peripheral precocious puberty Premature thelarche Congenital adrenal hyperplasia. |
| url | http://www.ijrm.ir/library/upload/article/af_26939531)%2089-34-6%20OK.pdf |
| work_keys_str_mv | AT fatemehsafari etiologyofprecociouspuberty10yearsstudyinendocrinereserchcentrefirouzgartehran AT farzanehrohani etiologyofprecociouspuberty10yearsstudyinendocrinereserchcentrefirouzgartehran AT shadabsalehpur etiologyofprecociouspuberty10yearsstudyinendocrinereserchcentrefirouzgartehran |