Vaccination against SARS-CoV-2 Does Not Protect against the Development of Anosmia in a Hamster Model
Anosmia, a total or partial loss of the ability to smell, is one of the most frequently documented sequelae of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Persistent anosmia is associated with a decrease in quality of life. Here, we assess the impact of virus lineage and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/11/10/1564 |
| _version_ | 1797572070510428160 |
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| author | Rachel A. Reyna Jordyn Walker Brooke Mitchell Divya P. Shinde Jessica A. Plante Scott C. Weaver Kenneth S. Plante |
| author_facet | Rachel A. Reyna Jordyn Walker Brooke Mitchell Divya P. Shinde Jessica A. Plante Scott C. Weaver Kenneth S. Plante |
| author_sort | Rachel A. Reyna |
| collection | DOAJ |
| description | Anosmia, a total or partial loss of the ability to smell, is one of the most frequently documented sequelae of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Persistent anosmia is associated with a decrease in quality of life. Here, we assess the impact of virus lineage and vaccination status on anosmia development in the golden Syrian hamster model. To characterize anosmia driven by current variants, we assessed olfactory function in hamsters infected with SARS-CoV-2 lineages A, BA.2, BA.5, BQ.1, and BQ.1.1 using a buried food detection test. We found that significant anosmia occurs upon infection with all variants with a significant correlation between disease severity and degree of anosmia. Moreover, we found that vaccination with either the Pfizer (BNT16b2) or Moderna (mRNA-1273) mRNA vaccines does not protect against anosmia, despite protection against severe disease. |
| first_indexed | 2024-03-10T20:49:32Z |
| format | Article |
| id | doaj.art-15d0ed691e0243c6822103b48191ecdf |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T20:49:32Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-15d0ed691e0243c6822103b48191ecdf2023-11-19T18:24:36ZengMDPI AGVaccines2076-393X2023-10-011110156410.3390/vaccines11101564Vaccination against SARS-CoV-2 Does Not Protect against the Development of Anosmia in a Hamster ModelRachel A. Reyna0Jordyn Walker1Brooke Mitchell2Divya P. Shinde3Jessica A. Plante4Scott C. Weaver5Kenneth S. Plante6Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USAWorld Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555, USAWorld Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555, USAWorld Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555, USAWorld Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555, USAWorld Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555, USAWorld Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555, USAAnosmia, a total or partial loss of the ability to smell, is one of the most frequently documented sequelae of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Persistent anosmia is associated with a decrease in quality of life. Here, we assess the impact of virus lineage and vaccination status on anosmia development in the golden Syrian hamster model. To characterize anosmia driven by current variants, we assessed olfactory function in hamsters infected with SARS-CoV-2 lineages A, BA.2, BA.5, BQ.1, and BQ.1.1 using a buried food detection test. We found that significant anosmia occurs upon infection with all variants with a significant correlation between disease severity and degree of anosmia. Moreover, we found that vaccination with either the Pfizer (BNT16b2) or Moderna (mRNA-1273) mRNA vaccines does not protect against anosmia, despite protection against severe disease.https://www.mdpi.com/2076-393X/11/10/1564SARS-CoV-2sequelaeanosmiavaccination |
| spellingShingle | Rachel A. Reyna Jordyn Walker Brooke Mitchell Divya P. Shinde Jessica A. Plante Scott C. Weaver Kenneth S. Plante Vaccination against SARS-CoV-2 Does Not Protect against the Development of Anosmia in a Hamster Model Vaccines SARS-CoV-2 sequelae anosmia vaccination |
| title | Vaccination against SARS-CoV-2 Does Not Protect against the Development of Anosmia in a Hamster Model |
| title_full | Vaccination against SARS-CoV-2 Does Not Protect against the Development of Anosmia in a Hamster Model |
| title_fullStr | Vaccination against SARS-CoV-2 Does Not Protect against the Development of Anosmia in a Hamster Model |
| title_full_unstemmed | Vaccination against SARS-CoV-2 Does Not Protect against the Development of Anosmia in a Hamster Model |
| title_short | Vaccination against SARS-CoV-2 Does Not Protect against the Development of Anosmia in a Hamster Model |
| title_sort | vaccination against sars cov 2 does not protect against the development of anosmia in a hamster model |
| topic | SARS-CoV-2 sequelae anosmia vaccination |
| url | https://www.mdpi.com/2076-393X/11/10/1564 |
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