The rates and symptoms of natural and breakthrough infection pre- and post- Covid-19 non-mRNA vaccination at various peaks amongst Iranian healthcare workers
Abstract Background/Aims The aim of this study was to determine the rate of natural and breakthrough infection and related symptoms of Covid-19 amongst Iranian healthcare workers (HCWs) who were vaccinated by different non-mRNA-based vaccines at peak points. Methods In this cross-sectional study, th...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Virology Journal |
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| Online Access: | https://doi.org/10.1186/s12985-023-02156-2 |
| _version_ | 1797453856593936384 |
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| author | Marzieh Jamalidoust Owrang Eilami Zahra Ashkan Mazyar Ziyaeyan Nasrin Aliabadi Mohammad Habibi |
| author_facet | Marzieh Jamalidoust Owrang Eilami Zahra Ashkan Mazyar Ziyaeyan Nasrin Aliabadi Mohammad Habibi |
| author_sort | Marzieh Jamalidoust |
| collection | DOAJ |
| description | Abstract Background/Aims The aim of this study was to determine the rate of natural and breakthrough infection and related symptoms of Covid-19 amongst Iranian healthcare workers (HCWs) who were vaccinated by different non-mRNA-based vaccines at peak points. Methods In this cross-sectional study, the RT-PCR test was performed for a total of 10,581 HCWs suspicious of Covid-19 infection. For each HCW, the frequency of SARS-CoV-2 infection and the time of transmission based on vaccination administration time and schedule were examined during different waves of the pandemic. Based on these findings, the study patients were divided into three groups: natural, natural/breakthrough, and breakthrough. Results In total, 53% of the HCWs were exposed to SARS-CoV-2 infection between 1 and 5 times within two years after the current pandemic, while 20.7% and 32.3% experienced natural and breakthrough SARS-CoV-2 infection, respectively. Only 6% of the breakthrough-infected HCWs had naturally contracted SARS-CoV-2 infection during the initial waves. The highest natural peaks of infection occurred during the interval administration of the first and second dose of the first vaccination series, while the single highest peak of breakthrough infection belonged to the Omicron wave. It occurred simultaneously with the administration of the third vaccination dose. On the other hand, the highest rate of reinfection was observed amongst people who had received the Sinopharm and Bharat vaccines full-doses. Conclusion This study compared the clinical differences between the two peaks of Omicron and Delta. This study indicates the rates of natural and breakthrough SARS-CoV-2 infections according to vaccination schedules and different waves of the pandemic. |
| first_indexed | 2024-03-09T15:28:55Z |
| format | Article |
| id | doaj.art-15d1108a15c3457498621add60931c0c |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-03-09T15:28:55Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-15d1108a15c3457498621add60931c0c2023-11-26T12:20:17ZengBMCVirology Journal1743-422X2023-08-012011810.1186/s12985-023-02156-2The rates and symptoms of natural and breakthrough infection pre- and post- Covid-19 non-mRNA vaccination at various peaks amongst Iranian healthcare workersMarzieh Jamalidoust0Owrang Eilami1Zahra Ashkan2Mazyar Ziyaeyan3Nasrin Aliabadi4Mohammad Habibi5Department of Virology, Professor Alborzi Clinical Microbiology Research Center, Namazi Hospital, Shiraz University of Medical SciencesDepartment of Family Medicine and Infectious Disease, Shiraz University of Medical SciencesDepartment of Biology, Faculty of Basic Science, Shahrekord UniversityDepartment of Virology, Professor Alborzi Clinical Microbiology Research Center, Namazi Hospital, Shiraz University of Medical SciencesDepartment of Virology, Professor Alborzi Clinical Microbiology Research Center, Namazi Hospital, Shiraz University of Medical SciencesStatistics and Information Technology Management, Shiraz University of Medical SciencesAbstract Background/Aims The aim of this study was to determine the rate of natural and breakthrough infection and related symptoms of Covid-19 amongst Iranian healthcare workers (HCWs) who were vaccinated by different non-mRNA-based vaccines at peak points. Methods In this cross-sectional study, the RT-PCR test was performed for a total of 10,581 HCWs suspicious of Covid-19 infection. For each HCW, the frequency of SARS-CoV-2 infection and the time of transmission based on vaccination administration time and schedule were examined during different waves of the pandemic. Based on these findings, the study patients were divided into three groups: natural, natural/breakthrough, and breakthrough. Results In total, 53% of the HCWs were exposed to SARS-CoV-2 infection between 1 and 5 times within two years after the current pandemic, while 20.7% and 32.3% experienced natural and breakthrough SARS-CoV-2 infection, respectively. Only 6% of the breakthrough-infected HCWs had naturally contracted SARS-CoV-2 infection during the initial waves. The highest natural peaks of infection occurred during the interval administration of the first and second dose of the first vaccination series, while the single highest peak of breakthrough infection belonged to the Omicron wave. It occurred simultaneously with the administration of the third vaccination dose. On the other hand, the highest rate of reinfection was observed amongst people who had received the Sinopharm and Bharat vaccines full-doses. Conclusion This study compared the clinical differences between the two peaks of Omicron and Delta. This study indicates the rates of natural and breakthrough SARS-CoV-2 infections according to vaccination schedules and different waves of the pandemic.https://doi.org/10.1186/s12985-023-02156-2Breakthrough infectionHealthcare workerNatural infectionSARS-C0V-2Vaccination |
| spellingShingle | Marzieh Jamalidoust Owrang Eilami Zahra Ashkan Mazyar Ziyaeyan Nasrin Aliabadi Mohammad Habibi The rates and symptoms of natural and breakthrough infection pre- and post- Covid-19 non-mRNA vaccination at various peaks amongst Iranian healthcare workers Virology Journal Breakthrough infection Healthcare worker Natural infection SARS-C0V-2 Vaccination |
| title | The rates and symptoms of natural and breakthrough infection pre- and post- Covid-19 non-mRNA vaccination at various peaks amongst Iranian healthcare workers |
| title_full | The rates and symptoms of natural and breakthrough infection pre- and post- Covid-19 non-mRNA vaccination at various peaks amongst Iranian healthcare workers |
| title_fullStr | The rates and symptoms of natural and breakthrough infection pre- and post- Covid-19 non-mRNA vaccination at various peaks amongst Iranian healthcare workers |
| title_full_unstemmed | The rates and symptoms of natural and breakthrough infection pre- and post- Covid-19 non-mRNA vaccination at various peaks amongst Iranian healthcare workers |
| title_short | The rates and symptoms of natural and breakthrough infection pre- and post- Covid-19 non-mRNA vaccination at various peaks amongst Iranian healthcare workers |
| title_sort | rates and symptoms of natural and breakthrough infection pre and post covid 19 non mrna vaccination at various peaks amongst iranian healthcare workers |
| topic | Breakthrough infection Healthcare worker Natural infection SARS-C0V-2 Vaccination |
| url | https://doi.org/10.1186/s12985-023-02156-2 |
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