Characterization of two second-site mutations preventing wild type protein aggregation caused by a dominant negative PMA1 mutant.
The correct biogenesis and localization of Pma1 at the plasma membrane is essential for yeast growth. A subset of PMA1 mutations behave as dominant negative because they produce aberrantly folded proteins that form protein aggregates, which in turn provoke the aggregation of the wild type protein. O...
Main Authors: | Pilar Eraso, Francisco Portillo, María J Mazón |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3692421?pdf=render |
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