Retinal malperfusion in albuminuric Type 1 diabetes mellitus patients without clinical signs of diabetic retinopathy: a prospective pilot study
Abstract Background To report fluorescein angiography findings in a group of albuminuric Type 1 diabetes mellitus (T1DM) patients without diabetic retinopathy. Methods Fifteen albuminuric T1DM patients with normal/near normal estimated glomerular filtration rate without diabetic retinopathy underwen...
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| Format: | Article |
| Language: | English |
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BMC
2017-12-01
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| Series: | International Journal of Retina and Vitreous |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40942-017-0102-y |
| _version_ | 1818657198513848320 |
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| author | Fernando Korn Malerbi Caio Vinicius Regatieri João Roberto de Sa Paulo Henrique Morales Michel Eid Farah Sergio Atala Dib |
| author_facet | Fernando Korn Malerbi Caio Vinicius Regatieri João Roberto de Sa Paulo Henrique Morales Michel Eid Farah Sergio Atala Dib |
| author_sort | Fernando Korn Malerbi |
| collection | DOAJ |
| description | Abstract Background To report fluorescein angiography findings in a group of albuminuric Type 1 diabetes mellitus (T1DM) patients without diabetic retinopathy. Methods Fifteen albuminuric T1DM patients with normal/near normal estimated glomerular filtration rate without diabetic retinopathy underwent fluorescein angiography; presence of microaneurysms, vascular permeability changes and retinal malperfusion were evaluated. Results Fluorescein angiography revealed microaneurysms, blood-retinal barrier breakdown and retinal ischemia in 10 (67%) and 11 (73%); 8 (53%) and 9 (60%); 2 (13%) and 5 (33%) of patients at baseline and follow up, respectively. Follow up time averaged 24.6 months, minimum follow up time was 20 months. Patients who presented retinal malperfusion had higher HbA1C and lower estimated glomerular filtration rate. Conclusions Most albuminuric T1DM patients with a normal fundus exam had angiographic signs of diabetic retinopathy, some presenting retinal malperfusion. Retinal changes may be found with more sensitive testing in these patients, especially with impaired estimated glomerular filtration rate, even if the fundus exam is normal, and fluorescein angiography should be considered. These findings point to a homogenous presentation of the diabetic microangiopathies. |
| first_indexed | 2024-12-17T03:37:40Z |
| format | Article |
| id | doaj.art-15d3cd8af2604039a7e25054d767ff6e |
| institution | Directory Open Access Journal |
| issn | 2056-9920 |
| language | English |
| last_indexed | 2024-12-17T03:37:40Z |
| publishDate | 2017-12-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Retina and Vitreous |
| spelling | doaj.art-15d3cd8af2604039a7e25054d767ff6e2022-12-21T22:05:05ZengBMCInternational Journal of Retina and Vitreous2056-99202017-12-01311710.1186/s40942-017-0102-yRetinal malperfusion in albuminuric Type 1 diabetes mellitus patients without clinical signs of diabetic retinopathy: a prospective pilot studyFernando Korn Malerbi0Caio Vinicius Regatieri1João Roberto de Sa2Paulo Henrique Morales3Michel Eid Farah4Sergio Atala Dib5Department of Ophthalmology, Federal University of São PauloDepartment of Ophthalmology, Federal University of São PauloDepartment of Endocrinology, Federal University of São PauloDepartment of Ophthalmology, Federal University of São PauloDepartment of Ophthalmology, Federal University of São PauloDepartment of Endocrinology, Federal University of São PauloAbstract Background To report fluorescein angiography findings in a group of albuminuric Type 1 diabetes mellitus (T1DM) patients without diabetic retinopathy. Methods Fifteen albuminuric T1DM patients with normal/near normal estimated glomerular filtration rate without diabetic retinopathy underwent fluorescein angiography; presence of microaneurysms, vascular permeability changes and retinal malperfusion were evaluated. Results Fluorescein angiography revealed microaneurysms, blood-retinal barrier breakdown and retinal ischemia in 10 (67%) and 11 (73%); 8 (53%) and 9 (60%); 2 (13%) and 5 (33%) of patients at baseline and follow up, respectively. Follow up time averaged 24.6 months, minimum follow up time was 20 months. Patients who presented retinal malperfusion had higher HbA1C and lower estimated glomerular filtration rate. Conclusions Most albuminuric T1DM patients with a normal fundus exam had angiographic signs of diabetic retinopathy, some presenting retinal malperfusion. Retinal changes may be found with more sensitive testing in these patients, especially with impaired estimated glomerular filtration rate, even if the fundus exam is normal, and fluorescein angiography should be considered. These findings point to a homogenous presentation of the diabetic microangiopathies.http://link.springer.com/article/10.1186/s40942-017-0102-yType 1 diabetes mellitusDiabetic retinopathyFluorescein angiographyNephropathyAlbuminuriaEstimated glomerular filtration rate |
| spellingShingle | Fernando Korn Malerbi Caio Vinicius Regatieri João Roberto de Sa Paulo Henrique Morales Michel Eid Farah Sergio Atala Dib Retinal malperfusion in albuminuric Type 1 diabetes mellitus patients without clinical signs of diabetic retinopathy: a prospective pilot study International Journal of Retina and Vitreous Type 1 diabetes mellitus Diabetic retinopathy Fluorescein angiography Nephropathy Albuminuria Estimated glomerular filtration rate |
| title | Retinal malperfusion in albuminuric Type 1 diabetes mellitus patients without clinical signs of diabetic retinopathy: a prospective pilot study |
| title_full | Retinal malperfusion in albuminuric Type 1 diabetes mellitus patients without clinical signs of diabetic retinopathy: a prospective pilot study |
| title_fullStr | Retinal malperfusion in albuminuric Type 1 diabetes mellitus patients without clinical signs of diabetic retinopathy: a prospective pilot study |
| title_full_unstemmed | Retinal malperfusion in albuminuric Type 1 diabetes mellitus patients without clinical signs of diabetic retinopathy: a prospective pilot study |
| title_short | Retinal malperfusion in albuminuric Type 1 diabetes mellitus patients without clinical signs of diabetic retinopathy: a prospective pilot study |
| title_sort | retinal malperfusion in albuminuric type 1 diabetes mellitus patients without clinical signs of diabetic retinopathy a prospective pilot study |
| topic | Type 1 diabetes mellitus Diabetic retinopathy Fluorescein angiography Nephropathy Albuminuria Estimated glomerular filtration rate |
| url | http://link.springer.com/article/10.1186/s40942-017-0102-y |
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