Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies
Cells respond to genotoxic stress through a series of complex protein pathways called DNA damage response (DDR). These monitoring mechanisms ensure the maintenance and the transfer of a correct genome to daughter cells through a selection of DNA repair, cell cycle regulation, and programmed cell dea...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/15/3819 |
| _version_ | 1797525695845367808 |
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| author | Caroline Molinaro Alain Martoriati Katia Cailliau |
| author_facet | Caroline Molinaro Alain Martoriati Katia Cailliau |
| author_sort | Caroline Molinaro |
| collection | DOAJ |
| description | Cells respond to genotoxic stress through a series of complex protein pathways called DNA damage response (DDR). These monitoring mechanisms ensure the maintenance and the transfer of a correct genome to daughter cells through a selection of DNA repair, cell cycle regulation, and programmed cell death processes. Canonical or non-canonical DDRs are highly organized and controlled to play crucial roles in genome stability and diversity. When altered or mutated, the proteins in these complex networks lead to many diseases that share common features, and to tumor formation. In recent years, technological advances have made it possible to benefit from the principles and mechanisms of DDR to target and eliminate cancer cells. These new types of treatments are adapted to the different types of tumor sensitivity and could benefit from a combination of therapies to ensure maximal efficiency. |
| first_indexed | 2024-03-10T09:17:33Z |
| format | Article |
| id | doaj.art-15d65005e3cc455994ff9aec9d60aa0b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:17:33Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-15d65005e3cc455994ff9aec9d60aa0b2023-11-22T05:28:23ZengMDPI AGCancers2072-66942021-07-011315381910.3390/cancers13153819Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer StrategiesCaroline Molinaro0Alain Martoriati1Katia Cailliau2Univ. Lille, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille, FranceUniv. Lille, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille, FranceUniv. Lille, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille, FranceCells respond to genotoxic stress through a series of complex protein pathways called DNA damage response (DDR). These monitoring mechanisms ensure the maintenance and the transfer of a correct genome to daughter cells through a selection of DNA repair, cell cycle regulation, and programmed cell death processes. Canonical or non-canonical DDRs are highly organized and controlled to play crucial roles in genome stability and diversity. When altered or mutated, the proteins in these complex networks lead to many diseases that share common features, and to tumor formation. In recent years, technological advances have made it possible to benefit from the principles and mechanisms of DDR to target and eliminate cancer cells. These new types of treatments are adapted to the different types of tumor sensitivity and could benefit from a combination of therapies to ensure maximal efficiency.https://www.mdpi.com/2072-6694/13/15/3819DNA damage responseDNA damage therapyDNA repairDDR inhibitorscell cyclecancers |
| spellingShingle | Caroline Molinaro Alain Martoriati Katia Cailliau Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies Cancers DNA damage response DNA damage therapy DNA repair DDR inhibitors cell cycle cancers |
| title | Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies |
| title_full | Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies |
| title_fullStr | Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies |
| title_full_unstemmed | Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies |
| title_short | Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies |
| title_sort | proteins from the dna damage response regulation dysfunction and anticancer strategies |
| topic | DNA damage response DNA damage therapy DNA repair DDR inhibitors cell cycle cancers |
| url | https://www.mdpi.com/2072-6694/13/15/3819 |
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