Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review
Introduction: Approximately 10–40 million travelers get Traveler's Diarrhea (TD) yearly. A significant decrease in TD incidence has not been achieved by depending solely on antibiotic prophylaxis and educational initiatives. Using prebiotics to prevent TD has also not been examined in previous...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-05-01
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| Series: | Travel Medicine and Infectious Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1477893924000176 |
| _version_ | 1827256593972985856 |
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| author | Basmah F. Alharbi Abeer A. Alateek |
| author_facet | Basmah F. Alharbi Abeer A. Alateek |
| author_sort | Basmah F. Alharbi |
| collection | DOAJ |
| description | Introduction: Approximately 10–40 million travelers get Traveler's Diarrhea (TD) yearly. A significant decrease in TD incidence has not been achieved by depending solely on antibiotic prophylaxis and educational initiatives. Using prebiotics to prevent TD has also not been examined in previous evaluations of probiotics for TD, which failed to consider the strain-specificity of probiotic efficacy. This review investigates the overall effects of probiotics on preventing TD, including the impact of dosage, duration, and age. Methods: Standard literature databases were searched without restriction on publication year or language. The following criteria are included: randomized controlled trials (RCTs) in English or non-English unrestricted to publication year, excluding animal and observational studies. This systematic review applied the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Results: Of the 166 screened papers, 10 RCTs were included. Lactobacillus acidophilus showed no efficacy in preventing TD except when mixed with other strains. Other genera of lactobacilli showed a protection rate of up to 39% against TD. Similarly, Saccharomyces cerevisiae and Saccharomyces boulardii have been effective in preventing TD. Conclusion: Studies investigating probiotics as a preventive measure for TD remain limited. Only a few probiotics that reduce TD risk exist. Based on this systematic review and meta-analysis, specific probiotic strains, including L. acidophilus, L. rhamnosus, L. fermentum, S. cerevisiae, and S. boulardii, may prevent TD. The effect of additional probiotic strains on TD prevention must be further investigated. |
| first_indexed | 2024-04-24T21:42:16Z |
| format | Article |
| id | doaj.art-15d6c884ca6a40cdac4ccbf224c0f8a4 |
| institution | Directory Open Access Journal |
| issn | 1873-0442 |
| language | English |
| last_indexed | 2025-03-22T01:41:23Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Travel Medicine and Infectious Disease |
| spelling | doaj.art-15d6c884ca6a40cdac4ccbf224c0f8a42024-05-09T04:35:35ZengElsevierTravel Medicine and Infectious Disease1873-04422024-05-0159102703Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic reviewBasmah F. Alharbi0Abeer A. Alateek1Department of Basic Health Science, College of Applied Medical Sciences, Qassim University, Buraydah, 51452, Saudi Arabia; Corresponding author.Department of Medical Laboratory, College of Applied Medical Sciences, Qassim University, Buraydah, 51452, Saudi ArabiaIntroduction: Approximately 10–40 million travelers get Traveler's Diarrhea (TD) yearly. A significant decrease in TD incidence has not been achieved by depending solely on antibiotic prophylaxis and educational initiatives. Using prebiotics to prevent TD has also not been examined in previous evaluations of probiotics for TD, which failed to consider the strain-specificity of probiotic efficacy. This review investigates the overall effects of probiotics on preventing TD, including the impact of dosage, duration, and age. Methods: Standard literature databases were searched without restriction on publication year or language. The following criteria are included: randomized controlled trials (RCTs) in English or non-English unrestricted to publication year, excluding animal and observational studies. This systematic review applied the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Results: Of the 166 screened papers, 10 RCTs were included. Lactobacillus acidophilus showed no efficacy in preventing TD except when mixed with other strains. Other genera of lactobacilli showed a protection rate of up to 39% against TD. Similarly, Saccharomyces cerevisiae and Saccharomyces boulardii have been effective in preventing TD. Conclusion: Studies investigating probiotics as a preventive measure for TD remain limited. Only a few probiotics that reduce TD risk exist. Based on this systematic review and meta-analysis, specific probiotic strains, including L. acidophilus, L. rhamnosus, L. fermentum, S. cerevisiae, and S. boulardii, may prevent TD. The effect of additional probiotic strains on TD prevention must be further investigated.http://www.sciencedirect.com/science/article/pii/S1477893924000176ProbioticsPrebioticDiarrheaLactobacilliSaccharomycesRandomized controlled trial |
| spellingShingle | Basmah F. Alharbi Abeer A. Alateek Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review Travel Medicine and Infectious Disease Probiotics Prebiotic Diarrhea Lactobacilli Saccharomyces Randomized controlled trial |
| title | Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review |
| title_full | Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review |
| title_fullStr | Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review |
| title_full_unstemmed | Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review |
| title_short | Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review |
| title_sort | investigating the influence of probiotics in preventing traveler s diarrhea meta analysis based systematic review |
| topic | Probiotics Prebiotic Diarrhea Lactobacilli Saccharomyces Randomized controlled trial |
| url | http://www.sciencedirect.com/science/article/pii/S1477893924000176 |
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