Serum anti mullerian hormone and renalase levels in predicting the risk of preeclampsia
Objective: The aim of the study was to explore the association of serum AMH and Renalase with the risk of preeclampsia thereby assessing them as screening tools, reducing the risk of gravid consequences of preeclampsia. Materials and methods: This cross-sectional study recruited n = 95 pregnant wome...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-03-01
|
| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455919300038 |
| _version_ | 1818924373501804544 |
|---|---|
| author | Zehra Jamil Sana Shahid Erum Baig Rida Ahmad Faryal Subhani Syeda Sadia Fatima |
| author_facet | Zehra Jamil Sana Shahid Erum Baig Rida Ahmad Faryal Subhani Syeda Sadia Fatima |
| author_sort | Zehra Jamil |
| collection | DOAJ |
| description | Objective: The aim of the study was to explore the association of serum AMH and Renalase with the risk of preeclampsia thereby assessing them as screening tools, reducing the risk of gravid consequences of preeclampsia. Materials and methods: This cross-sectional study recruited n = 95 pregnant women between 14 and 32 gestational weeks. They were categorized as a) women with gestational hypertension (n = 45); b) women with pre-eclampsia (n = 20) and c) normotensive pregnant women (n = 30) according to the ACOG criteria. Anthropometrics data and blood and urine samples were collected. AMH and Renalase levels were measured by ELISA assay. Results: The mean age of study cohort was 27.3 ± 6.2 year and weight was 65.1 ± 14.1 kg. Blood pressures were significantly higher in pre-eclamptic patients versus both the gestational hypertensive females and controls (p < 0.05). AMH was found to be significantly higher in controls but no difference was observed between gestational hypertensive and pre-eclamptic patients. No difference was seen for serum Renalase among the three groups (p > 0.05). AMH showed a negative weak correlation with diastolic blood pressure (r = −0.272; p = 0.008) that remained significant even after adjustment (r = −0.236; p = 0.023) whereas Renalase did not show any difference (r = −0.051; p > 0.05). Females with low levels of AMH were 1.07 times at risk of developing hypertension even after adjustment for age and BMI (p < 0.05). Conclusion: Low AMH levels may lead to hypertension in pregnancy suggesting a role in detecting vascular diseases as well as its effect on ovarian aging. However, further research is required to establish a causal relationship. Keywords: Pre-eclampsia, Hypertension, AMH, Renalase |
| first_indexed | 2024-12-20T02:24:18Z |
| format | Article |
| id | doaj.art-15d6d5e6157342e1b1cc2aea746cc7d9 |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-20T02:24:18Z |
| publishDate | 2019-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-15d6d5e6157342e1b1cc2aea746cc7d92022-12-21T19:56:45ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592019-03-01582188191Serum anti mullerian hormone and renalase levels in predicting the risk of preeclampsiaZehra Jamil0Sana Shahid1Erum Baig2Rida Ahmad3Faryal Subhani4Syeda Sadia Fatima5Department of Biological & Biomedical Sciences, Aga Khan University, PakistanDepartment of Physiology, Sir Syed College of Medical Sciences for Girls, PakistanMedical Students, Aga Khan University, PakistanMedical Students, Aga Khan University, PakistanMedical Students, Aga Khan University, PakistanDepartment of Biological & Biomedical Sciences, Aga Khan University, Pakistan; Corresponding author. Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.Objective: The aim of the study was to explore the association of serum AMH and Renalase with the risk of preeclampsia thereby assessing them as screening tools, reducing the risk of gravid consequences of preeclampsia. Materials and methods: This cross-sectional study recruited n = 95 pregnant women between 14 and 32 gestational weeks. They were categorized as a) women with gestational hypertension (n = 45); b) women with pre-eclampsia (n = 20) and c) normotensive pregnant women (n = 30) according to the ACOG criteria. Anthropometrics data and blood and urine samples were collected. AMH and Renalase levels were measured by ELISA assay. Results: The mean age of study cohort was 27.3 ± 6.2 year and weight was 65.1 ± 14.1 kg. Blood pressures were significantly higher in pre-eclamptic patients versus both the gestational hypertensive females and controls (p < 0.05). AMH was found to be significantly higher in controls but no difference was observed between gestational hypertensive and pre-eclamptic patients. No difference was seen for serum Renalase among the three groups (p > 0.05). AMH showed a negative weak correlation with diastolic blood pressure (r = −0.272; p = 0.008) that remained significant even after adjustment (r = −0.236; p = 0.023) whereas Renalase did not show any difference (r = −0.051; p > 0.05). Females with low levels of AMH were 1.07 times at risk of developing hypertension even after adjustment for age and BMI (p < 0.05). Conclusion: Low AMH levels may lead to hypertension in pregnancy suggesting a role in detecting vascular diseases as well as its effect on ovarian aging. However, further research is required to establish a causal relationship. Keywords: Pre-eclampsia, Hypertension, AMH, Renalasehttp://www.sciencedirect.com/science/article/pii/S1028455919300038 |
| spellingShingle | Zehra Jamil Sana Shahid Erum Baig Rida Ahmad Faryal Subhani Syeda Sadia Fatima Serum anti mullerian hormone and renalase levels in predicting the risk of preeclampsia Taiwanese Journal of Obstetrics & Gynecology |
| title | Serum anti mullerian hormone and renalase levels in predicting the risk of preeclampsia |
| title_full | Serum anti mullerian hormone and renalase levels in predicting the risk of preeclampsia |
| title_fullStr | Serum anti mullerian hormone and renalase levels in predicting the risk of preeclampsia |
| title_full_unstemmed | Serum anti mullerian hormone and renalase levels in predicting the risk of preeclampsia |
| title_short | Serum anti mullerian hormone and renalase levels in predicting the risk of preeclampsia |
| title_sort | serum anti mullerian hormone and renalase levels in predicting the risk of preeclampsia |
| url | http://www.sciencedirect.com/science/article/pii/S1028455919300038 |
| work_keys_str_mv | AT zehrajamil serumantimullerianhormoneandrenalaselevelsinpredictingtheriskofpreeclampsia AT sanashahid serumantimullerianhormoneandrenalaselevelsinpredictingtheriskofpreeclampsia AT erumbaig serumantimullerianhormoneandrenalaselevelsinpredictingtheriskofpreeclampsia AT ridaahmad serumantimullerianhormoneandrenalaselevelsinpredictingtheriskofpreeclampsia AT faryalsubhani serumantimullerianhormoneandrenalaselevelsinpredictingtheriskofpreeclampsia AT syedasadiafatima serumantimullerianhormoneandrenalaselevelsinpredictingtheriskofpreeclampsia |