Manipulation of KLF4 Expression Generates iPSCs Paused at Successive Stages of Reprogramming

Manipulation of KLF4 Expression Generates iPSCs Paused at Successive Stages of Reprogramming

The detailed mechanism of reprogramming somatic cells into induced pluripotent stem cells (iPSCs) remains largely unknown. Partially reprogrammed iPSCs are informative and useful for understanding the mechanism of reprogramming but remain technically difficult to generate in a predictable and reprod...

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Bibliographic Details
Main Authors: Ken Nishimura, Tetsuo Kato, Chen Chen, Lalhaba Oinam, Emi Shiomitsu, Daisuke Ayakawa, Manami Ohtaka, Aya Fukuda, Mahito Nakanishi, Koji Hisatake
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671114002689

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