Carcinogenesis in prostate cancer: The role of long non-coding RNAs
LncRNAs appear to play a considerable role in tumourigenesis through regulating key processes in cancer cells such as proliferative signalling, replicative immortality, invasion and metastasis, evasion of growth suppressors, induction of angiogenesis and resistance to apoptosis. LncRNAs have been re...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2018-03-01
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| Series: | Non-coding RNA Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054017300355 |
| _version_ | 1827279955945324544 |
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| author | John Aird Anne-Marie Baird Marvin C.J. Lim Ray McDermott Stephen P. Finn Steven G. Gray |
| author_facet | John Aird Anne-Marie Baird Marvin C.J. Lim Ray McDermott Stephen P. Finn Steven G. Gray |
| author_sort | John Aird |
| collection | DOAJ |
| description | LncRNAs appear to play a considerable role in tumourigenesis through regulating key processes in cancer cells such as proliferative signalling, replicative immortality, invasion and metastasis, evasion of growth suppressors, induction of angiogenesis and resistance to apoptosis. LncRNAs have been reported to play a role in prostate cancer, particularly in regulating the androgen receptor signalling pathway. In this review article, we summarise the role of 34 lncRNAs in prostate cancer with a particular focus on their role in the androgen receptor signalling pathway and the epithelial to mesenchymal transition pathway. |
| first_indexed | 2024-04-24T08:27:37Z |
| format | Article |
| id | doaj.art-15d860e9c4004e07a13b37a6c11a2b8d |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-04-24T08:27:37Z |
| publishDate | 2018-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-15d860e9c4004e07a13b37a6c11a2b8d2024-04-16T20:57:46ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402018-03-01312938Carcinogenesis in prostate cancer: The role of long non-coding RNAsJohn Aird0Anne-Marie Baird1Marvin C.J. Lim2Ray McDermott3Stephen P. Finn4Steven G. Gray5Department of Histopathology and Morbid Anatomy, School of Medicine, Trinity College Dublin, IrelandDepartment of Histopathology and Morbid Anatomy, School of Medicine, Trinity College Dublin, Ireland; Thoracic Oncology Research Group, Trinity Translational Medical Institute, St. James's Hospital, Dublin, Ireland; Department of Clinical Medicine, Trinity College Dublin, Dublin, Ireland; Cancer and Ageing Research Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, AustraliaDepartment of Histopathology and Morbid Anatomy, School of Medicine, Trinity College Dublin, Ireland; Department of Medical Oncology, St. Vincent's University Hospital, Dublin, Ireland; Department of Medical Oncology, Tallaght Hospital, Dublin, IrelandDepartment of Medical Oncology, St. Vincent's University Hospital, Dublin, Ireland; Department of Medical Oncology, Tallaght Hospital, Dublin, IrelandDepartment of Histopathology and Morbid Anatomy, School of Medicine, Trinity College Dublin, Ireland; Department of Clinical Medicine, Trinity College Dublin, Dublin, IrelandDepartment of Clinical Medicine, Trinity College Dublin, Dublin, Ireland; HOPE Directorate, St. James's Hospital, Dublin, Ireland; Labmed Directorate, St. James's Hospital, Dublin, Ireland; School of Biological Sciences, Dublin Institute of Technology, Dublin, Ireland; Corresponding author. Thoracic Oncology Research Group, Trinity Translational Medical Institute, St. James's Hospital, Dublin, Ireland.LncRNAs appear to play a considerable role in tumourigenesis through regulating key processes in cancer cells such as proliferative signalling, replicative immortality, invasion and metastasis, evasion of growth suppressors, induction of angiogenesis and resistance to apoptosis. LncRNAs have been reported to play a role in prostate cancer, particularly in regulating the androgen receptor signalling pathway. In this review article, we summarise the role of 34 lncRNAs in prostate cancer with a particular focus on their role in the androgen receptor signalling pathway and the epithelial to mesenchymal transition pathway.http://www.sciencedirect.com/science/article/pii/S2468054017300355 |
| spellingShingle | John Aird Anne-Marie Baird Marvin C.J. Lim Ray McDermott Stephen P. Finn Steven G. Gray Carcinogenesis in prostate cancer: The role of long non-coding RNAs Non-coding RNA Research |
| title | Carcinogenesis in prostate cancer: The role of long non-coding RNAs |
| title_full | Carcinogenesis in prostate cancer: The role of long non-coding RNAs |
| title_fullStr | Carcinogenesis in prostate cancer: The role of long non-coding RNAs |
| title_full_unstemmed | Carcinogenesis in prostate cancer: The role of long non-coding RNAs |
| title_short | Carcinogenesis in prostate cancer: The role of long non-coding RNAs |
| title_sort | carcinogenesis in prostate cancer the role of long non coding rnas |
| url | http://www.sciencedirect.com/science/article/pii/S2468054017300355 |
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