Association of chondroadherin with leiomyosarcoma
The leiomyosarcoma (LMS) subtype of uterine sarcoma accounts for 1–2 % of uterine neoplasia cases. The present study aimed to demonstrate that the gene and protein chondroadherin (CHAD) levels may serve as novel biomarkers for predicting prognosis and devising novel treatment models for LMS. A total...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Gynecologic Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578923000139 |
| _version_ | 1827971430457802752 |
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| author | Sefik Gokce Dilsad Herkiloglu Ecmel İsik Kaygusuz Ozge Cevik Sarfraz Ahmad |
| author_facet | Sefik Gokce Dilsad Herkiloglu Ecmel İsik Kaygusuz Ozge Cevik Sarfraz Ahmad |
| author_sort | Sefik Gokce |
| collection | DOAJ |
| description | The leiomyosarcoma (LMS) subtype of uterine sarcoma accounts for 1–2 % of uterine neoplasia cases. The present study aimed to demonstrate that the gene and protein chondroadherin (CHAD) levels may serve as novel biomarkers for predicting prognosis and devising novel treatment models for LMS. A total of 12 patients diagnosed with LMS and 13 patients diagnosed with myomas were included in the study. The extent of tumour cell necrosis, cellularity and atypia and the mitotic index of each patient with LMS were determined. CHAD gene expression was significantly increased in cancerous tissues compared with that in fibroid tissues (2.17 ± 0.88 vs 3.19 ± 1.61; P = 0.047). The mean CHAD protein expression in tissues was higher in LMS cases but this was not statistically significant (217.38 ± 93.9 vs 177.13 ± 66.67;P = 0.226). Positive significant correlations were obtained between CHAD gene expression and mitotic index (r = 0.476; P = 0.008), tumour size (r = 0.385; P = 0.029) and necrosis (r = 0.455; P = 0.011). Furthermore, there were significant positive correlations between CHAD protein expression levels and tumour size (r = 0.360; P = 0.039) and necrosis (r = 0.377; P = 0.032). The present study was the first to demonstrate the significance of CHAD in LMS. The results suggested that, due to its association with LMS, CHAD has predictive value in determining the prognosis of patients with LMS. |
| first_indexed | 2024-04-09T19:08:52Z |
| format | Article |
| id | doaj.art-15d92be7713d48ae9c858cdd8fe7c700 |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-04-09T19:08:52Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-15d92be7713d48ae9c858cdd8fe7c7002023-04-07T06:50:25ZengElsevierGynecologic Oncology Reports2352-57892023-04-0146101144Association of chondroadherin with leiomyosarcomaSefik Gokce0Dilsad Herkiloglu1Ecmel İsik Kaygusuz2Ozge Cevik3Sarfraz Ahmad4Department of Obstetrics and Gynecology, Yeni Yuzyil University School of Medicine, İstanbul, TurkeyDepartment of Obstetrics and Gynecology, Yeni Yuzyil University School of Medicine, İstanbul, Turkey; Corresponding author at: Department of Obstetrics and Gynecology, Yeni Yuzyil University School of Medicine, no: 51 Cukurcesme St., Istanbul 34245, Turkey.Pathology Department, Zeynep Kamil Training and Research Hospital, İstanbul, TurkeyAydin Adnan Menderes University, School of Medicine, Department of Biochemistry, Aydin, TurkeyAdventHealth Medical Center, Orlando, FL 32804, USAThe leiomyosarcoma (LMS) subtype of uterine sarcoma accounts for 1–2 % of uterine neoplasia cases. The present study aimed to demonstrate that the gene and protein chondroadherin (CHAD) levels may serve as novel biomarkers for predicting prognosis and devising novel treatment models for LMS. A total of 12 patients diagnosed with LMS and 13 patients diagnosed with myomas were included in the study. The extent of tumour cell necrosis, cellularity and atypia and the mitotic index of each patient with LMS were determined. CHAD gene expression was significantly increased in cancerous tissues compared with that in fibroid tissues (2.17 ± 0.88 vs 3.19 ± 1.61; P = 0.047). The mean CHAD protein expression in tissues was higher in LMS cases but this was not statistically significant (217.38 ± 93.9 vs 177.13 ± 66.67;P = 0.226). Positive significant correlations were obtained between CHAD gene expression and mitotic index (r = 0.476; P = 0.008), tumour size (r = 0.385; P = 0.029) and necrosis (r = 0.455; P = 0.011). Furthermore, there were significant positive correlations between CHAD protein expression levels and tumour size (r = 0.360; P = 0.039) and necrosis (r = 0.377; P = 0.032). The present study was the first to demonstrate the significance of CHAD in LMS. The results suggested that, due to its association with LMS, CHAD has predictive value in determining the prognosis of patients with LMS.http://www.sciencedirect.com/science/article/pii/S2352578923000139LeiomyosarcomaChondroadherinMyoma |
| spellingShingle | Sefik Gokce Dilsad Herkiloglu Ecmel İsik Kaygusuz Ozge Cevik Sarfraz Ahmad Association of chondroadherin with leiomyosarcoma Gynecologic Oncology Reports Leiomyosarcoma Chondroadherin Myoma |
| title | Association of chondroadherin with leiomyosarcoma |
| title_full | Association of chondroadherin with leiomyosarcoma |
| title_fullStr | Association of chondroadherin with leiomyosarcoma |
| title_full_unstemmed | Association of chondroadherin with leiomyosarcoma |
| title_short | Association of chondroadherin with leiomyosarcoma |
| title_sort | association of chondroadherin with leiomyosarcoma |
| topic | Leiomyosarcoma Chondroadherin Myoma |
| url | http://www.sciencedirect.com/science/article/pii/S2352578923000139 |
| work_keys_str_mv | AT sefikgokce associationofchondroadherinwithleiomyosarcoma AT dilsadherkiloglu associationofchondroadherinwithleiomyosarcoma AT ecmelisikkaygusuz associationofchondroadherinwithleiomyosarcoma AT ozgecevik associationofchondroadherinwithleiomyosarcoma AT sarfrazahmad associationofchondroadherinwithleiomyosarcoma |