Disease activity and functional outcomes in non-radiographic spondyloarthritis versus ankylosing spondylitis – preliminary results
Introduction. Spondyloarthritis (SpA) represent a heterogeneous group of chronic inflammatory conditions sharing clinical, genetic, imaging and therapeutic features. Objectives. To analyze the clinical and biological characteristics, disease activity and functional impact in non-radiographic axial...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2022-09-01
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| Series: | Romanian Journal of Rheumatology |
| Subjects: | |
| Online Access: | https://rjr.com.ro/articles/2022.3/RJR_2022_3_Art-08.pdf |
| _version_ | 1827988765436542976 |
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| author | Ana-Maria Doca Andreea Odobasu Andreea Hortolomei Mara Russu Alexandra Popescu Cristina Pomirleanu Georgiana Strugariu Codrina Ancuta |
| author_facet | Ana-Maria Doca Andreea Odobasu Andreea Hortolomei Mara Russu Alexandra Popescu Cristina Pomirleanu Georgiana Strugariu Codrina Ancuta |
| author_sort | Ana-Maria Doca |
| collection | DOAJ |
| description | Introduction. Spondyloarthritis (SpA) represent a heterogeneous group of chronic inflammatory conditions sharing clinical, genetic, imaging and therapeutic features.
Objectives. To analyze the clinical and biological characteristics, disease activity and functional impact in non-radiographic axial SpA (nr-axSpA) versus ankylosing spondylitis (AS).
Material and method. Cross-sectional observational 12 months study on 46 patients with axial SpA; disease related parameters (clinical, biological, activity and functionality indices) and treatment options were compared in disease categories (nr-axSpA and AS).
Outcomes. AS was diagnosed in 73.9%, and nr-axSpA in 26.1% cases. The majority of patients with nr-axSpA were women (72% vs 28%), with a younger age at onset (35.2±9.5 years vs 41±0.6 years) and a shorter time to diagnosis (3±0.5 vs 5.5±3.2 years). C-reactive protein levels were significantly higher in AS compared to nr-axSpA (2.2±0.5 vs 1.28±0.7) (p<0.05). However, there were no significant differences between activity (ASDAS-CRP: 3.4±1.2 vs 3.2±0.9; BASDAI: 5.8±1.3 vs 5.6±1.1) and functionality measures (BASFI: 5.8±1.4 vs 5.7±1.2) in (p >0.05) in AS vs nr-axSpA.
Conclusions. Although nr-axSpA occurs frequently in women and may present with lower CRP levels, there are similar trends in disease activity and functional outcomes in both disease categories of the ax-SpA spectrum. Both nr-axSpA and AS patients experience high disease burden. |
| first_indexed | 2024-04-10T00:08:29Z |
| format | Article |
| id | doaj.art-15dcf7deca7c488da0ee1cc7496b3337 |
| institution | Directory Open Access Journal |
| issn | 1843-0791 2069-6086 |
| language | English |
| last_indexed | 2024-04-10T00:08:29Z |
| publishDate | 2022-09-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Rheumatology |
| spelling | doaj.art-15dcf7deca7c488da0ee1cc7496b33372023-03-16T15:08:14ZengAmaltea Medical Publishing HouseRomanian Journal of Rheumatology1843-07912069-60862022-09-0131312913310.37897/RJR.2022.3.8Disease activity and functional outcomes in non-radiographic spondyloarthritis versus ankylosing spondylitis – preliminary resultsAna-Maria Doca0Andreea Odobasu1Andreea Hortolomei2Mara Russu3Alexandra Popescu4Cristina Pomirleanu5Georgiana Strugariu6Codrina Ancuta7Rheumatology 2 Department, Clinical Rehabilitation Hospital Iasi, Romania; ”Grigore T. Popa” University of Medicine and Pharmacy Iasi, RomaniaRheumatology 2 Department, Clinical Rehabilitation Hospital Iasi, Romania; ”Grigore T. Popa” University of Medicine and Pharmacy Iasi, RomaniaRheumatology 2 Department, Clinical Rehabilitation Hospital Iasi, Romania; ”Grigore T. Popa” University of Medicine and Pharmacy Iasi, RomaniaRheumatology 2 Department, Clinical Rehabilitation Hospital Iasi, Romania; ”Grigore T. Popa” University of Medicine and Pharmacy Iasi, RomaniaRheumatology 2 Department, Clinical Rehabilitation Hospital Iasi, Romania; ”Grigore T. Popa” University of Medicine and Pharmacy Iasi, RomaniaRheumatology 2 Department, Clinical Rehabilitation Hospital Iasi, Romania; ”Grigore T. Popa” University of Medicine and Pharmacy Iasi, RomaniaRheumatology 2 Department, Clinical Rehabilitation Hospital Iasi, Romania; ”Grigore T. Popa” University of Medicine and Pharmacy Iasi, RomaniaRheumatology 2 Department, Clinical Rehabilitation Hospital Iasi, Romania; ”Grigore T. Popa” University of Medicine and Pharmacy Iasi, RomaniaIntroduction. Spondyloarthritis (SpA) represent a heterogeneous group of chronic inflammatory conditions sharing clinical, genetic, imaging and therapeutic features. Objectives. To analyze the clinical and biological characteristics, disease activity and functional impact in non-radiographic axial SpA (nr-axSpA) versus ankylosing spondylitis (AS). Material and method. Cross-sectional observational 12 months study on 46 patients with axial SpA; disease related parameters (clinical, biological, activity and functionality indices) and treatment options were compared in disease categories (nr-axSpA and AS). Outcomes. AS was diagnosed in 73.9%, and nr-axSpA in 26.1% cases. The majority of patients with nr-axSpA were women (72% vs 28%), with a younger age at onset (35.2±9.5 years vs 41±0.6 years) and a shorter time to diagnosis (3±0.5 vs 5.5±3.2 years). C-reactive protein levels were significantly higher in AS compared to nr-axSpA (2.2±0.5 vs 1.28±0.7) (p<0.05). However, there were no significant differences between activity (ASDAS-CRP: 3.4±1.2 vs 3.2±0.9; BASDAI: 5.8±1.3 vs 5.6±1.1) and functionality measures (BASFI: 5.8±1.4 vs 5.7±1.2) in (p >0.05) in AS vs nr-axSpA. Conclusions. Although nr-axSpA occurs frequently in women and may present with lower CRP levels, there are similar trends in disease activity and functional outcomes in both disease categories of the ax-SpA spectrum. Both nr-axSpA and AS patients experience high disease burden. https://rjr.com.ro/articles/2022.3/RJR_2022_3_Art-08.pdfnon-radiographic axial spondyloarthritisankylosing spondylitisdisease burdenactivityfunctional outcome |
| spellingShingle | Ana-Maria Doca Andreea Odobasu Andreea Hortolomei Mara Russu Alexandra Popescu Cristina Pomirleanu Georgiana Strugariu Codrina Ancuta Disease activity and functional outcomes in non-radiographic spondyloarthritis versus ankylosing spondylitis – preliminary results Romanian Journal of Rheumatology non-radiographic axial spondyloarthritis ankylosing spondylitis disease burden activity functional outcome |
| title | Disease activity and functional outcomes in non-radiographic spondyloarthritis versus ankylosing spondylitis – preliminary results |
| title_full | Disease activity and functional outcomes in non-radiographic spondyloarthritis versus ankylosing spondylitis – preliminary results |
| title_fullStr | Disease activity and functional outcomes in non-radiographic spondyloarthritis versus ankylosing spondylitis – preliminary results |
| title_full_unstemmed | Disease activity and functional outcomes in non-radiographic spondyloarthritis versus ankylosing spondylitis – preliminary results |
| title_short | Disease activity and functional outcomes in non-radiographic spondyloarthritis versus ankylosing spondylitis – preliminary results |
| title_sort | disease activity and functional outcomes in non radiographic spondyloarthritis versus ankylosing spondylitis preliminary results |
| topic | non-radiographic axial spondyloarthritis ankylosing spondylitis disease burden activity functional outcome |
| url | https://rjr.com.ro/articles/2022.3/RJR_2022_3_Art-08.pdf |
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