Low rate of SARS-CoV-2 incident infection identified by weekly screening PCR in a prospective year-long cohort study.
<h4>Background</h4>Asymptomatic and pre-symptomatic SARS-CoV-2 infections may contribute to ongoing community transmission, however, the benefit of routine screening of asymptomatic individuals in low-risk populations is unclear.<h4>Methods</h4>To identify SARS-CoV-2 infectio...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0274078 |
| _version_ | 1798017150687903744 |
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| author | Whitney E Harrington Winnie Yeung Ingrid A Beck Fred D Mast John Houck Sheila Styrchak Leslie R Miller Song Li Micaela Haglund Yonghou Jiang Blair Armistead Jackson Wallner Tina Nguyen Daisy Ko Samantha Hardy Alyssa Oldroyd Ana Gervassi John D Aitchison Lisa M Frenkel |
| author_facet | Whitney E Harrington Winnie Yeung Ingrid A Beck Fred D Mast John Houck Sheila Styrchak Leslie R Miller Song Li Micaela Haglund Yonghou Jiang Blair Armistead Jackson Wallner Tina Nguyen Daisy Ko Samantha Hardy Alyssa Oldroyd Ana Gervassi John D Aitchison Lisa M Frenkel |
| author_sort | Whitney E Harrington |
| collection | DOAJ |
| description | <h4>Background</h4>Asymptomatic and pre-symptomatic SARS-CoV-2 infections may contribute to ongoing community transmission, however, the benefit of routine screening of asymptomatic individuals in low-risk populations is unclear.<h4>Methods</h4>To identify SARS-CoV-2 infections 553 seronegative individuals were prospectively followed for 52 weeks. From 4/2020-7/2021, participants submitted weekly self-collected nasal swabs for rtPCR and completed symptom and exposure surveys.<h4>Results</h4>Incident SARS2-CoV-2 infections were identified in 9/553 (1.6%) participants. Comparisons of SARS2-CoV-2(+) to SARS2-CoV-2(-) participants revealed significantly more close contacts outside the household (median: 5 versus 3; p = 0.005). The incidence of infection was higher among unvaccinated/partially vaccinated than among fully vaccinated participants (9/7,679 versus 0/6,845 person-weeks; p = 0.004). At notification of positive test result, eight cases were symptomatic and one pre-symptomatic.<h4>Conclusions</h4>These data suggest that weekly SARS2-CoV2 surveillance by rtPCR did not efficiently detect pre-symptomatic infections in unvaccinated participants. |
| first_indexed | 2024-04-11T16:02:12Z |
| format | Article |
| id | doaj.art-15dfe1206e9f4c68afbb50aa728d2773 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T16:02:12Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-15dfe1206e9f4c68afbb50aa728d27732022-12-22T04:14:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01179e027407810.1371/journal.pone.0274078Low rate of SARS-CoV-2 incident infection identified by weekly screening PCR in a prospective year-long cohort study.Whitney E HarringtonWinnie YeungIngrid A BeckFred D MastJohn HouckSheila StyrchakLeslie R MillerSong LiMicaela HaglundYonghou JiangBlair ArmisteadJackson WallnerTina NguyenDaisy KoSamantha HardyAlyssa OldroydAna GervassiJohn D AitchisonLisa M Frenkel<h4>Background</h4>Asymptomatic and pre-symptomatic SARS-CoV-2 infections may contribute to ongoing community transmission, however, the benefit of routine screening of asymptomatic individuals in low-risk populations is unclear.<h4>Methods</h4>To identify SARS-CoV-2 infections 553 seronegative individuals were prospectively followed for 52 weeks. From 4/2020-7/2021, participants submitted weekly self-collected nasal swabs for rtPCR and completed symptom and exposure surveys.<h4>Results</h4>Incident SARS2-CoV-2 infections were identified in 9/553 (1.6%) participants. Comparisons of SARS2-CoV-2(+) to SARS2-CoV-2(-) participants revealed significantly more close contacts outside the household (median: 5 versus 3; p = 0.005). The incidence of infection was higher among unvaccinated/partially vaccinated than among fully vaccinated participants (9/7,679 versus 0/6,845 person-weeks; p = 0.004). At notification of positive test result, eight cases were symptomatic and one pre-symptomatic.<h4>Conclusions</h4>These data suggest that weekly SARS2-CoV2 surveillance by rtPCR did not efficiently detect pre-symptomatic infections in unvaccinated participants.https://doi.org/10.1371/journal.pone.0274078 |
| spellingShingle | Whitney E Harrington Winnie Yeung Ingrid A Beck Fred D Mast John Houck Sheila Styrchak Leslie R Miller Song Li Micaela Haglund Yonghou Jiang Blair Armistead Jackson Wallner Tina Nguyen Daisy Ko Samantha Hardy Alyssa Oldroyd Ana Gervassi John D Aitchison Lisa M Frenkel Low rate of SARS-CoV-2 incident infection identified by weekly screening PCR in a prospective year-long cohort study. PLoS ONE |
| title | Low rate of SARS-CoV-2 incident infection identified by weekly screening PCR in a prospective year-long cohort study. |
| title_full | Low rate of SARS-CoV-2 incident infection identified by weekly screening PCR in a prospective year-long cohort study. |
| title_fullStr | Low rate of SARS-CoV-2 incident infection identified by weekly screening PCR in a prospective year-long cohort study. |
| title_full_unstemmed | Low rate of SARS-CoV-2 incident infection identified by weekly screening PCR in a prospective year-long cohort study. |
| title_short | Low rate of SARS-CoV-2 incident infection identified by weekly screening PCR in a prospective year-long cohort study. |
| title_sort | low rate of sars cov 2 incident infection identified by weekly screening pcr in a prospective year long cohort study |
| url | https://doi.org/10.1371/journal.pone.0274078 |
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