Urothelial Carcinoma of the Upper Urinary Tract That Becomes Resectable After Neoadjuvant Chemotherapy: A Case Report and Review of the Literature
Upper tract urothelial carcinoma (UTUC) is less common than bladder cancer, but its incidence is increasing. Neoadjuvant chemotherapy (NAC) has been the treatment focus for locally invasive and high-grade UTUC. Herein, we aimed to present a case of a locally advanced non-metastatic UTUC, which was t...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2021-03-01
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| Series: | Journal of Urological Surgery |
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http://jurolsurgery.org/archives/archive-detail/article-preview/urothelial-carcinoma-of-the-upper-urinary-tract-th/46842
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| _version_ | 1797916062419779584 |
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| author | Mustafa Dinçkal Fuat Kızılay Serdar Kalemci Adnan Şimşir |
| author_facet | Mustafa Dinçkal Fuat Kızılay Serdar Kalemci Adnan Şimşir |
| author_sort | Mustafa Dinçkal |
| collection | DOAJ |
| description | Upper tract urothelial carcinoma (UTUC) is less common than bladder cancer, but its incidence is increasing. Neoadjuvant chemotherapy (NAC) has been the treatment focus for locally invasive and high-grade UTUC. Herein, we aimed to present a case of a locally advanced non-metastatic UTUC, which was thought to be unresectable due to local invasion, but surgically treated successfully after NAC. A 64-year-old male patient was admitted to another hospital because of right flank pain, which was not accompanied by macroscopic haematuria. He did not have comorbidities in his anamnesis, but he had a history of smoking 40 packs/year. A locally invasive right kidney tumour was detected in cross-sectional imaging performed at another hospital. He underwent surgery in that hospital, but radical nephroureterectomy could not be performed because of local invasion. He presented to our urology department. He was subsequently started with cisplatin-based NAC, which led to the resolution of local invasion. After NAC, right radical nephroureterectomy and ipsilateral bladder cuff excision with subcostal and Gibson incisions were performed. No signs of mass invasion or lymph node involvement were detected intraoperatively. He was examined 3 months after surgery. On cystourethroscopy, the bladder was normal and cytology was benign. No recurrence or metastasis was detected on the whole-body computed tomography. NAC is one of the valuable multimodal treatment options, enables surgery in locally invasive UTUC and contributes positively to survival rate. |
| first_indexed | 2024-04-10T12:51:20Z |
| format | Article |
| id | doaj.art-15e0c006612a41418c0744f229787cc5 |
| institution | Directory Open Access Journal |
| issn | 2148-9580 2148-9580 |
| language | English |
| last_indexed | 2024-04-10T12:51:20Z |
| publishDate | 2021-03-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Journal of Urological Surgery |
| spelling | doaj.art-15e0c006612a41418c0744f229787cc52023-02-15T16:13:43ZengGalenos YayineviJournal of Urological Surgery2148-95802148-95802021-03-0181656810.4274/jus.galenos.2020.402513049054Urothelial Carcinoma of the Upper Urinary Tract That Becomes Resectable After Neoadjuvant Chemotherapy: A Case Report and Review of the LiteratureMustafa Dinçkal0Fuat Kızılay1Serdar Kalemci2Adnan Şimşir3 Ege University Faculty of Medicine, Department of Urology, İzmir, Turkiye Ege University Faculty of Medicine, Department of Urology, İzmir, Turkiye Ege University Faculty of Medicine, Department of Urology, İzmir, Turkiye Ege University Faculty of Medicine, Department of Urology, İzmir, Turkiye Upper tract urothelial carcinoma (UTUC) is less common than bladder cancer, but its incidence is increasing. Neoadjuvant chemotherapy (NAC) has been the treatment focus for locally invasive and high-grade UTUC. Herein, we aimed to present a case of a locally advanced non-metastatic UTUC, which was thought to be unresectable due to local invasion, but surgically treated successfully after NAC. A 64-year-old male patient was admitted to another hospital because of right flank pain, which was not accompanied by macroscopic haematuria. He did not have comorbidities in his anamnesis, but he had a history of smoking 40 packs/year. A locally invasive right kidney tumour was detected in cross-sectional imaging performed at another hospital. He underwent surgery in that hospital, but radical nephroureterectomy could not be performed because of local invasion. He presented to our urology department. He was subsequently started with cisplatin-based NAC, which led to the resolution of local invasion. After NAC, right radical nephroureterectomy and ipsilateral bladder cuff excision with subcostal and Gibson incisions were performed. No signs of mass invasion or lymph node involvement were detected intraoperatively. He was examined 3 months after surgery. On cystourethroscopy, the bladder was normal and cytology was benign. No recurrence or metastasis was detected on the whole-body computed tomography. NAC is one of the valuable multimodal treatment options, enables surgery in locally invasive UTUC and contributes positively to survival rate. http://jurolsurgery.org/archives/archive-detail/article-preview/urothelial-carcinoma-of-the-upper-urinary-tract-th/46842 oncologyurooncologyurothelial carcinomanephrectomynephroureterectomyneoadjuvant chemotherapy |
| spellingShingle | Mustafa Dinçkal Fuat Kızılay Serdar Kalemci Adnan Şimşir Urothelial Carcinoma of the Upper Urinary Tract That Becomes Resectable After Neoadjuvant Chemotherapy: A Case Report and Review of the Literature Journal of Urological Surgery oncology urooncology urothelial carcinoma nephrectomy nephroureterectomy neoadjuvant chemotherapy |
| title | Urothelial Carcinoma of the Upper Urinary Tract That Becomes Resectable After Neoadjuvant Chemotherapy: A Case Report and Review of the Literature |
| title_full | Urothelial Carcinoma of the Upper Urinary Tract That Becomes Resectable After Neoadjuvant Chemotherapy: A Case Report and Review of the Literature |
| title_fullStr | Urothelial Carcinoma of the Upper Urinary Tract That Becomes Resectable After Neoadjuvant Chemotherapy: A Case Report and Review of the Literature |
| title_full_unstemmed | Urothelial Carcinoma of the Upper Urinary Tract That Becomes Resectable After Neoadjuvant Chemotherapy: A Case Report and Review of the Literature |
| title_short | Urothelial Carcinoma of the Upper Urinary Tract That Becomes Resectable After Neoadjuvant Chemotherapy: A Case Report and Review of the Literature |
| title_sort | urothelial carcinoma of the upper urinary tract that becomes resectable after neoadjuvant chemotherapy a case report and review of the literature |
| topic | oncology urooncology urothelial carcinoma nephrectomy nephroureterectomy neoadjuvant chemotherapy |
| url |
http://jurolsurgery.org/archives/archive-detail/article-preview/urothelial-carcinoma-of-the-upper-urinary-tract-th/46842
|
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