Impact of BioFire FilmArray respiratory panel results on antibiotic days of therapy in different clinical settings
Abstract Objective: The BioFire FilmArray Respiratory Panel (RFA) has been proposed as a tool that can aid in the timely diagnosis and treatment of respiratory tract infections but its effect on antibiotic prescribing among adult patients has varied. We evaluated the impact of RFA result on antibi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2021-01-01
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| Series: | Antimicrobial Stewardship & Healthcare Epidemiology |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2732494X21001649/type/journal_article |
| _version_ | 1811157210893385728 |
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| author | Jenna J. Manatrey-Lancaster Amanda M. Bushman Meagan E. Caligiuri Rossana Rosa |
| author_facet | Jenna J. Manatrey-Lancaster Amanda M. Bushman Meagan E. Caligiuri Rossana Rosa |
| author_sort | Jenna J. Manatrey-Lancaster |
| collection | DOAJ |
| description |
Abstract
Objective:
The BioFire FilmArray Respiratory Panel (RFA) has been proposed as a tool that can aid in the timely diagnosis and treatment of respiratory tract infections but its effect on antibiotic prescribing among adult patients has varied. We evaluated the impact of RFA result on antibiotic days of therapy (DOTs) in 2 distinct cohorts: hospitalized patients and patients discharged from the emergency department (ED).
Design:
Retrospective cohort study.
Setting:
The study was conducted in 3 community hospitals in Des Moines, Iowa, from March 3 to March 16, 2019.
Patients:
Adults aged >18 years.
Methods:
Potential outcome means and average treatment effects for RFA results on antibiotic DOTs were estimated. Inverse probability of treatment weighting with regression adjustment was used.
Results:
We identified 243 patients each in the hospitalized and ED-discharged cohorts. Among hospitalized patients, RFA results did not affect antibiotic DOTs. Among patients discharged from the ED, we found that if all patients had had influenza detected, the average DOTs would have been 2.3 DOTs (−3.2 to −1.4) less than the average observed if all the patients had had a negative RFA (P < .0001); no differences in DOTs were observed when comparing an RFA with a noninfluenza virus detected compared to an RFA with negative results.
Conclusions:
The impact of RFA results on antibiotic DOTs varies by clinical setting, and reductions were observed only among patients discharged from the ED who had influenza A or B detected.
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| first_indexed | 2024-04-10T05:03:17Z |
| format | Article |
| id | doaj.art-15e33b21bdb442d0812a9be01b0676bb |
| institution | Directory Open Access Journal |
| issn | 2732-494X |
| language | English |
| last_indexed | 2024-04-10T05:03:17Z |
| publishDate | 2021-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Antimicrobial Stewardship & Healthcare Epidemiology |
| spelling | doaj.art-15e33b21bdb442d0812a9be01b0676bb2023-03-09T12:27:47ZengCambridge University PressAntimicrobial Stewardship & Healthcare Epidemiology2732-494X2021-01-01110.1017/ash.2021.164Impact of BioFire FilmArray respiratory panel results on antibiotic days of therapy in different clinical settingsJenna J. Manatrey-Lancaster0Amanda M. Bushman1Meagan E. Caligiuri2Rossana Rosa3https://orcid.org/0000-0002-3755-7780Department of Pharmacy, UnityPoint Health-Des Moines, Des Moines, IowaDepartment of Pharmacy, UnityPoint Health-Des Moines, Des Moines, IowaDepartment of Pharmacy, UnityPoint Health-Des Moines, Des Moines, IowaInfectious Diseases Service, UnityPoint Health-Des Moines, Des Moines, Iowa Department of Internal Medicine, University of Iowa-Des Moines Campus, Des Moines, Iowa Abstract Objective: The BioFire FilmArray Respiratory Panel (RFA) has been proposed as a tool that can aid in the timely diagnosis and treatment of respiratory tract infections but its effect on antibiotic prescribing among adult patients has varied. We evaluated the impact of RFA result on antibiotic days of therapy (DOTs) in 2 distinct cohorts: hospitalized patients and patients discharged from the emergency department (ED). Design: Retrospective cohort study. Setting: The study was conducted in 3 community hospitals in Des Moines, Iowa, from March 3 to March 16, 2019. Patients: Adults aged >18 years. Methods: Potential outcome means and average treatment effects for RFA results on antibiotic DOTs were estimated. Inverse probability of treatment weighting with regression adjustment was used. Results: We identified 243 patients each in the hospitalized and ED-discharged cohorts. Among hospitalized patients, RFA results did not affect antibiotic DOTs. Among patients discharged from the ED, we found that if all patients had had influenza detected, the average DOTs would have been 2.3 DOTs (−3.2 to −1.4) less than the average observed if all the patients had had a negative RFA (P < .0001); no differences in DOTs were observed when comparing an RFA with a noninfluenza virus detected compared to an RFA with negative results. Conclusions: The impact of RFA results on antibiotic DOTs varies by clinical setting, and reductions were observed only among patients discharged from the ED who had influenza A or B detected. https://www.cambridge.org/core/product/identifier/S2732494X21001649/type/journal_article |
| spellingShingle | Jenna J. Manatrey-Lancaster Amanda M. Bushman Meagan E. Caligiuri Rossana Rosa Impact of BioFire FilmArray respiratory panel results on antibiotic days of therapy in different clinical settings Antimicrobial Stewardship & Healthcare Epidemiology |
| title | Impact of BioFire FilmArray respiratory panel results on antibiotic days of therapy in different clinical settings |
| title_full | Impact of BioFire FilmArray respiratory panel results on antibiotic days of therapy in different clinical settings |
| title_fullStr | Impact of BioFire FilmArray respiratory panel results on antibiotic days of therapy in different clinical settings |
| title_full_unstemmed | Impact of BioFire FilmArray respiratory panel results on antibiotic days of therapy in different clinical settings |
| title_short | Impact of BioFire FilmArray respiratory panel results on antibiotic days of therapy in different clinical settings |
| title_sort | impact of biofire filmarray respiratory panel results on antibiotic days of therapy in different clinical settings |
| url | https://www.cambridge.org/core/product/identifier/S2732494X21001649/type/journal_article |
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