Microglial roles in Alzheimer's disease: An agent‐based model to elucidate microglial spatiotemporal response to beta‐amyloid

Microglial roles in Alzheimer's disease: An agent‐based model to elucidate microglial spatiotemporal response to beta‐amyloid

Abstract Alzheimer's disease (AD) is characterized by beta‐amyloid (Aβ) plaques in the brain and widespread neuronal damage. Because of the high drug attrition rates in AD, there is increased interest in characterizing neuroimmune responses to Aβ plaques. In response to AD pathology, microglia...

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Bibliographic Details
Main Authors: Catherine Weathered, Sophia Bardehle, Choya Yoon, Niyanta Kumar, Cheryl E. G. Leyns, Matthew E. Kennedy, Peter Bloomingdale, Elsje Pienaar
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.13095

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