Family SES Is Associated with the Gut Microbiome in Infants and Children
Background: While early life exposures such as mode of birth, breastfeeding, and antibiotic use are established regulators of microbiome composition in early childhood, recent research suggests that the social environment may also exert influence. Two recent studies in adults demonstrated associatio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/8/1608 |
| _version_ | 1797522824041070592 |
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| author | Candace R. Lewis Kevin S. Bonham Shelley Hoeft McCann Alexandra R. Volpe Viren D’Sa Marcus Naymik Matt D. De Both Matthew J. Huentelman Kathryn Lemery-Chalfant Sarah K. Highlander Sean C. L. Deoni Vanja Klepac-Ceraj |
| author_facet | Candace R. Lewis Kevin S. Bonham Shelley Hoeft McCann Alexandra R. Volpe Viren D’Sa Marcus Naymik Matt D. De Both Matthew J. Huentelman Kathryn Lemery-Chalfant Sarah K. Highlander Sean C. L. Deoni Vanja Klepac-Ceraj |
| author_sort | Candace R. Lewis |
| collection | DOAJ |
| description | Background: While early life exposures such as mode of birth, breastfeeding, and antibiotic use are established regulators of microbiome composition in early childhood, recent research suggests that the social environment may also exert influence. Two recent studies in adults demonstrated associations between socioeconomic factors and microbiome composition. This study expands on this prior work by examining the association between family socioeconomic status (SES) and host genetics with microbiome composition in infants and children. Methods: Family SES was used to predict a latent variable representing six genera abundances generated from whole-genome shotgun sequencing. A polygenic score derived from a microbiome genome-wide association study was included to control for potential genetic associations. Associations between family SES and microbiome diversity were assessed. Results: <i>Anaerostipes</i>, <i>Bacteroides</i>, <i>Eubacterium</i>, <i>Faecalibacterium</i>, and <i>Lachnospiraceae</i> spp. significantly loaded onto a latent factor, which was significantly predicted by SES (<i>p</i> < 0.05) but not the polygenic score (<i>p</i> > 0.05). Our results indicate that SES did not predict alpha diversity but did predict beta diversity (<i>p</i> < 0.001). Conclusions: Our results demonstrate that modifiable environmental factors influence gut microbiome composition at an early age. These results are important as our understanding of gut microbiome influences on health continue to expand. |
| first_indexed | 2024-03-10T08:34:50Z |
| format | Article |
| id | doaj.art-15e54b04560544b2ae4194a82fc0b5e7 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T08:34:50Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-15e54b04560544b2ae4194a82fc0b5e72023-11-22T08:46:13ZengMDPI AGMicroorganisms2076-26072021-07-0198160810.3390/microorganisms9081608Family SES Is Associated with the Gut Microbiome in Infants and ChildrenCandace R. Lewis0Kevin S. Bonham1Shelley Hoeft McCann2Alexandra R. Volpe3Viren D’Sa4Marcus Naymik5Matt D. De Both6Matthew J. Huentelman7Kathryn Lemery-Chalfant8Sarah K. Highlander9Sean C. L. Deoni10Vanja Klepac-Ceraj11Neurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USADepartment of Biological Sciences, Wellesley College, Wellesley, MA 02481, USADepartment of Biological Sciences, Wellesley College, Wellesley, MA 02481, USAAdvanced Baby Imaging Lab, Hasbro Children’s Hospital, Rhode Island Hospital, Providence, RI 02903, USAAdvanced Baby Imaging Lab, Hasbro Children’s Hospital, Rhode Island Hospital, Providence, RI 02903, USANeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USANeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USANeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USAPsychology Department, Arizona State University, Tempe, AZ 85281, USAPathogen and Microbiome Division, Translational Genomics Research Institute North (TGen), Flagstaff, AZ 86005, USAAdvanced Baby Imaging Lab, Hasbro Children’s Hospital, Rhode Island Hospital, Providence, RI 02903, USADepartment of Biological Sciences, Wellesley College, Wellesley, MA 02481, USABackground: While early life exposures such as mode of birth, breastfeeding, and antibiotic use are established regulators of microbiome composition in early childhood, recent research suggests that the social environment may also exert influence. Two recent studies in adults demonstrated associations between socioeconomic factors and microbiome composition. This study expands on this prior work by examining the association between family socioeconomic status (SES) and host genetics with microbiome composition in infants and children. Methods: Family SES was used to predict a latent variable representing six genera abundances generated from whole-genome shotgun sequencing. A polygenic score derived from a microbiome genome-wide association study was included to control for potential genetic associations. Associations between family SES and microbiome diversity were assessed. Results: <i>Anaerostipes</i>, <i>Bacteroides</i>, <i>Eubacterium</i>, <i>Faecalibacterium</i>, and <i>Lachnospiraceae</i> spp. significantly loaded onto a latent factor, which was significantly predicted by SES (<i>p</i> < 0.05) but not the polygenic score (<i>p</i> > 0.05). Our results indicate that SES did not predict alpha diversity but did predict beta diversity (<i>p</i> < 0.001). Conclusions: Our results demonstrate that modifiable environmental factors influence gut microbiome composition at an early age. These results are important as our understanding of gut microbiome influences on health continue to expand.https://www.mdpi.com/2076-2607/9/8/1608socioeconomic statusinfantchildhoodmicrobiomestress |
| spellingShingle | Candace R. Lewis Kevin S. Bonham Shelley Hoeft McCann Alexandra R. Volpe Viren D’Sa Marcus Naymik Matt D. De Both Matthew J. Huentelman Kathryn Lemery-Chalfant Sarah K. Highlander Sean C. L. Deoni Vanja Klepac-Ceraj Family SES Is Associated with the Gut Microbiome in Infants and Children Microorganisms socioeconomic status infant childhood microbiome stress |
| title | Family SES Is Associated with the Gut Microbiome in Infants and Children |
| title_full | Family SES Is Associated with the Gut Microbiome in Infants and Children |
| title_fullStr | Family SES Is Associated with the Gut Microbiome in Infants and Children |
| title_full_unstemmed | Family SES Is Associated with the Gut Microbiome in Infants and Children |
| title_short | Family SES Is Associated with the Gut Microbiome in Infants and Children |
| title_sort | family ses is associated with the gut microbiome in infants and children |
| topic | socioeconomic status infant childhood microbiome stress |
| url | https://www.mdpi.com/2076-2607/9/8/1608 |
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