Everything in Moderation: Investigating the U-Shaped Link Between HDL Cholesterol and Adverse Outcomes
Despite historical evidence suggesting an inverse association between HDL cholesterol (HDL-C) and adverse cardiovascular events, pharmacological efforts to increase HDL-C and improve outcomes have not been successful. Recently, a U-shaped association between HDL-C and adverse events has been demonst...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2019-01-01
|
| Series: | US Cardiology Review |
| Online Access: | https://www.uscjournal.com/articles/u-shaped-link-between-hdl-cholesterol |
| _version_ | 1826933296230039552 |
|---|---|
| author | Marc P Allard-Ratick Pratik B Sandesara Arshed A Quyyumi Laurence S Sperling |
| author_facet | Marc P Allard-Ratick Pratik B Sandesara Arshed A Quyyumi Laurence S Sperling |
| author_sort | Marc P Allard-Ratick |
| collection | DOAJ |
| description | Despite historical evidence suggesting an inverse association between HDL cholesterol (HDL-C) and adverse cardiovascular events, pharmacological efforts to increase HDL-C and improve outcomes have not been successful. Recently, a U-shaped association between HDL-C and adverse events has been demonstrated in several population cohorts, further complicating our understanding of the clinical significance of HDL. Potential explanations for this finding include genetic mutations linked to very high HDL-C, impaired HDL function at high HDL-C levels, and residual confounding. However, our understanding of this association remains premature and needs further investigation. |
| first_indexed | 2024-03-07T17:41:39Z |
| format | Article |
| id | doaj.art-15e6a744a1e04d9aba20f49f6b741c29 |
| institution | Directory Open Access Journal |
| issn | 1758-3896 1758-390X |
| language | English |
| last_indexed | 2025-02-17T17:29:51Z |
| publishDate | 2019-01-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | US Cardiology Review |
| spelling | doaj.art-15e6a744a1e04d9aba20f49f6b741c292024-12-14T16:01:06ZengRadcliffe Medical MediaUS Cardiology Review1758-38961758-390X2019-01-01131495310.15420/usc.2019.3.2Everything in Moderation: Investigating the U-Shaped Link Between HDL Cholesterol and Adverse OutcomesMarc P Allard-Ratick0Pratik B Sandesara1Arshed A Quyyumi2Laurence S Sperling3Department of Internal Medicine, Emory University School of Medicine, Atlanta, GADivision of Cardiology, Department of Internal Medicine, Emory University School of Medicine, Atlanta, GADivision of Cardiology, Department of Internal Medicine, Emory University School of Medicine, Atlanta, GADivision of Cardiology, Department of Internal Medicine, Emory University School of Medicine, Atlanta, GADespite historical evidence suggesting an inverse association between HDL cholesterol (HDL-C) and adverse cardiovascular events, pharmacological efforts to increase HDL-C and improve outcomes have not been successful. Recently, a U-shaped association between HDL-C and adverse events has been demonstrated in several population cohorts, further complicating our understanding of the clinical significance of HDL. Potential explanations for this finding include genetic mutations linked to very high HDL-C, impaired HDL function at high HDL-C levels, and residual confounding. However, our understanding of this association remains premature and needs further investigation.https://www.uscjournal.com/articles/u-shaped-link-between-hdl-cholesterol |
| spellingShingle | Marc P Allard-Ratick Pratik B Sandesara Arshed A Quyyumi Laurence S Sperling Everything in Moderation: Investigating the U-Shaped Link Between HDL Cholesterol and Adverse Outcomes US Cardiology Review |
| title | Everything in Moderation: Investigating the U-Shaped Link Between HDL Cholesterol and Adverse Outcomes |
| title_full | Everything in Moderation: Investigating the U-Shaped Link Between HDL Cholesterol and Adverse Outcomes |
| title_fullStr | Everything in Moderation: Investigating the U-Shaped Link Between HDL Cholesterol and Adverse Outcomes |
| title_full_unstemmed | Everything in Moderation: Investigating the U-Shaped Link Between HDL Cholesterol and Adverse Outcomes |
| title_short | Everything in Moderation: Investigating the U-Shaped Link Between HDL Cholesterol and Adverse Outcomes |
| title_sort | everything in moderation investigating the u shaped link between hdl cholesterol and adverse outcomes |
| url | https://www.uscjournal.com/articles/u-shaped-link-between-hdl-cholesterol |
| work_keys_str_mv | AT marcpallardratick everythinginmoderationinvestigatingtheushapedlinkbetweenhdlcholesterolandadverseoutcomes AT pratikbsandesara everythinginmoderationinvestigatingtheushapedlinkbetweenhdlcholesterolandadverseoutcomes AT arshedaquyyumi everythinginmoderationinvestigatingtheushapedlinkbetweenhdlcholesterolandadverseoutcomes AT laurencessperling everythinginmoderationinvestigatingtheushapedlinkbetweenhdlcholesterolandadverseoutcomes |